Recombinant Human PFKFB1 protein (His tag)
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Recombinant Human PFKFB1 protein (His tag) is a Human Full Length protein, in the 2 to 471 aa range, expressed in Mammalian, with >95%, < 0.1 EU/µg endotoxin level, suitable for SDS-PAGE.
View Alternative Names
F6PK, PFRX, PFKFB1, PFK/FBPase 1
Reactivity data
Sequence info
Properties and storage information
Shipped at conditions
Appropriate short-term storage conditions
Appropriate long-term storage conditions
Storage information
Supplementary information
This supplementary information is collated from multiple sources and compiled automatically.
Biological function summary
PFKFB1 modulates the balance of carbohydrate metabolism. The protein manages levels of F26BP facilitating enhanced glycolysis or gluconeogenesis depending on metabolic demands. PFKFB1 does not form part of a larger enzymatic complex but it operates by itself to regulate metabolic processes. Its regulation involves allosteric changes and phosphorylation by other enzymes reflecting its importance in maintaining energy homeostasis.
Pathways
PFKFB1 features in both glycolytic and gluconeogenic pathways. The glycolysis pathway sees PFKFB1 influencing how cells convert glucose into pyruvate generating ATP. In the gluconeogenesis pathway PFKFB1 also contributes to converting non-carbohydrates into glucose. It interacts with proteins such as phosphofructokinase-1 (PFK-1) and fructose-16-bisphosphatase (FBPase-1) key regulators of the metabolic flux alongside PFKFB1.
Specifications
Form
Liquid
General info
Function
Synthesis and degradation of fructose 2,6-bisphosphate.
Sequence similarities
In the C-terminal section; belongs to the phosphoglycerate mutase family.
Target data
Complementary Products
Product promise
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