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AB160974

Recombinant Human PGCP protein (GST tag N-Terminus)

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Recombinant Human PGCP protein (GST tag N-Terminus) is a Human Full Length protein, in the 1 to 472 aa range, expressed in Wheat germ, suitable for ELISA, WB.

View Alternative Names

LCH1, PGCP, CPQ, Carboxypeptidase Q, Lysosomal dipeptidase, Plasma glutamate carboxypeptidase

1 Images
SDS-PAGE - Recombinant Human PGCP protein (GST tag N-Terminus) (AB160974)
  • SDS-PAGE

Unknown

SDS-PAGE - Recombinant Human PGCP protein (GST tag N-Terminus) (AB160974)

ab160974 on a 12.5% SDS-PAGE stained with Coomassie Blue.

Key facts

Expression system

Wheat germ

Tags

GST tag N-Terminus

Applications

ELISA, WB

applications

Biologically active

No

Accession

Q9Y646

Animal free

No

Carrier free

No

Species

Human

Storage buffer

pH: 8 Constituents: 0.79% Tris HCl, 0.31% Glutathione

storage-buffer

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Complementary Products

Primary Antibodies

AB96159

Anti-PGCP antibody

Western blot - Anti-PGCP antibody (AB96159)

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Proteins & Peptides

AB159808

Recombinant Human ZAN protein (GST tag N-Terminus)

SDS-PAGE - Recombinant Human ZAN protein (GST tag N-Terminus) (AB159808)

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Proteins & Peptides

AB159886

Recombinant Human ZP2 protein (GST tag N-Terminus)

SDS-PAGE - Recombinant Human ZP2 protein (GST tag N-Terminus) (AB159886)

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Proteins & Peptides

AB162402

Recombinant Human Zinc finger protein 691 (GST tag N-Terminus)

SDS-PAGE - Recombinant Human Zinc finger protein 691 (GST tag N-Terminus) (AB162402)

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Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Reactivity", "Dilution Info", "Notes"] }, "values": { "ELISA": { "reactivity":"TESTED_AND_REACTS", "dilution-info":"", "notes":"<p></p>" }, "WB": { "reactivity":"TESTED_AND_REACTS", "dilution-info":"", "notes":"<p></p>" } } }
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Sequence info

[{"sequence":"MKFLIFAFFGGVHLLSLCSGKAICKNGISKRTFEEIKEEIASCGDVAKAIINLAVYGKAQNRSYERLALLVDTVGPRLSGSKNLEKAIQIMYQNLQQDGLEKVHLEPVRIPHWERGEESAVMLEPRIHKIAILGLGSSIGTPPEGITAEVLVVTSFDELQRRASEARGKIVVYNQPYINYSRTVQYRTQGAVEAAKVGALASLIRSVASFSIYSPHTGIQEYQDGVPKIPTACITVEDAEMMSRMASHGIKIVIQLKMGAKTYPDTDSFNTVAEITGSKYPEQVVLVSGHLDSWDVGQGAMDDGGGAFISWEALSLIKDLGLRPKRTLRLVLWTAEEQGGVGAFQYYQLHKVNISNYSLVMESDAGTFLPTGLQFTGSEKARAIMEEVMSLLQPLNITQVLSHGEGTDINFWIQAGVPGASLLDDLYKYFFFHHSHGDTMTVMDPKQMNVAAAVWAVVSYVVADMEEMLPRS","proteinLength":"Full Length","predictedMolecularWeight":null,"actualMolecularWeight":null,"aminoAcidEnd":472,"aminoAcidStart":1,"nature":"Recombinant","expressionSystem":"Wheat germ","accessionNumber":"Q9Y646","tags":[{"tag":"GST","terminus":"N-Terminus"}]}]
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Properties and storage information

Shipped at conditions
Dry Ice
Appropriate short-term storage conditions
-80°C
Appropriate long-term storage conditions
-80°C
Aliquoting information
Upon delivery aliquot
Storage information
Avoid freeze / thaw cycle
False
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Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

The protein PGCP also known as plasma glutamate carboxypeptidase functions mechanically by catalyzing the cleavage of C-terminal glutamate residues from its substrates. PGCP with a molecular mass approximately 55 kDa is highly expressed in the liver and kidney. Researchers have observed its expression in both human and mouse tissues which implies a conserved role across species. PGCP participates in processes that maintain proper levels of free glutamate an important amino acid in metabolic pathways.
Biological function summary

PGCP modulates the balance of circulating peptides by hydrolyzing carboxy-terminal glutamate. It does not operate as part of a larger protein complex but functions independently. By regulating peptides PGCP helps in processes like protein degradation and recycling. It also influences the bioavailability of certain hormones and metabolites thereby affecting metabolic and signal transduction pathways.

Pathways

PGCP actively partakes in the regulation of blood coagulation and metabolism of amino acids. It interacts with proteins like angiotensin II as it processes bioactive peptides involved in blood pressure regulation. Through these actions PGCP affects the renin-angiotensin system which plays a critical role in cardiovascular health. Additionally PGCP associates with amino acid metabolism pathways where its role in glutamate modulation supports cellular energy production and neurotransmitter synthesis.

PGCP's dysregulation connects it to hypertension and metabolic syndrome. Researchers link altered PGCP activity with imbalances in the renin-angiotensin system leading to increased blood pressure. Furthermore its interaction with proteins like bradykinin influences inflammatory responses and researchers hypothesize its involvement in metabolic syndrome due to its role in amino acid processing. Understanding PGCP's contributions aids in exploring therapeutic interventions for these conditions.
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Specifications

Form

Liquid

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General info

Function

Carboxypeptidase that may play an important role in the hydrolysis of circulating peptides. Catalyzes the hydrolysis of dipeptides with unsubstituted terminals into amino acids. May play a role in the liberation of thyroxine hormone from its thyroglobulin (Tg) precursor.

Sequence similarities

Belongs to the peptidase M28 family.

Post-translational modifications

N-glycosylated. The secreted form is modified by hybrid or complex type oligosaccharide chains (By similarity).

Subcellular localisation

Lysosome

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Product protocols

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Target data

Carboxypeptidase that may play an important role in the hydrolysis of circulating peptides. Catalyzes the hydrolysis of dipeptides with unsubstituted terminals into amino acids. May play a role in the liberation of thyroxine hormone from its thyroglobulin (Tg) precursor.
See full target information CPQ
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