JavaScript is disabled in your browser. Please enable JavaScript to view this website.
AB132523

Recombinant Human PGRMC1 protein (GST tag N-Terminus)

Be the first to review this product! Submit a review

|

(0 Publication)

Recombinant Human PGRMC1 protein (GST tag N-Terminus) is a Human Full Length protein, in the 1 to 195 aa range, expressed in Wheat germ, suitable for SDS-PAGE, ELISA, WB.

View Alternative Names

HPR6.6, PGRMC, PGRMC1, Membrane-associated progesterone receptor component 1, mPR, Dap1, IZA

1 Images
SDS-PAGE - Recombinant Human PGRMC1 protein (GST tag N-Terminus) (AB132523)
  • SDS-PAGE

Unknown

SDS-PAGE - Recombinant Human PGRMC1 protein (GST tag N-Terminus) (AB132523)

12.5% SDS-PAGE analysis of ab132523 stained with Coomassie Blue.

Key facts

Expression system

Wheat germ

Tags

GST tag N-Terminus

Applications

WB, ELISA, SDS-PAGE

applications

Biologically active

No

Accession

O00264

Animal free

No

Carrier free

No

Species

Human

Storage buffer

pH: 8 Constituents: 0.79% Tris HCl, 0.31% Glutathione

storage-buffer

style
left-column

Complementary Products

Primary Antibodies

AB48012

Anti-PGRMC1 antibody

Western blot - Anti-PGRMC1 antibody (AB48012)

  • 4
  • 1
Primary Antibodies

AB171978

Anti-TIMMDC1/C3orf1 antibody [EPR11807]

RabMAb|Recombinant

Immunocytochemistry/ Immunofluorescence - Anti-TIMMDC1/C3orf1 antibody [EPR11807] (AB171978)

  • 0
  • 0
Proteins & Peptides

AB276686

Recombinant Human PGRP1B protein (His tag)

SDS-PAGE - Recombinant Human PGRP1B protein (His tag) (AB276686)

  • 0
  • 0
Primary Antibodies

AB28179

Anti-TFIIF antibody

ChIP - Anti-TFIIF antibody (AB28179)

  • 5
  • 2
style
left-column

Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Reactivity", "Dilution Info", "Notes"] }, "values": { "SDS-PAGE": { "reactivity":"TESTED_AND_REACTS", "dilution-info":"", "notes":"<p></p>" }, "ELISA": { "reactivity":"TESTED_AND_REACTS", "dilution-info":"", "notes":"<p></p>" }, "WB": { "reactivity":"TESTED_AND_REACTS", "dilution-info":"", "notes":"<p></p>" } } }
style
left-column
style
left-column

Sequence info

[{"sequence":"MAAEDVVATGADPSDLESGGLLHEIFTSPLNLLLLGLCIFLLYKIVRGDQPAASGDSDDDEPPPLPRLKRRDFTPAELRRFDGVQDPRILMAINGKVFDVTKGRKFYGPEGPYGVFAGRDASRGLATFCLDKEALKDEYDDLSDLTAAQQETLSDWESQFTFKYHHVGKLLKEGEEPTVYSDEEEPKDESARKND","proteinLength":"Full Length","predictedMolecularWeight":"48.1 kDa","actualMolecularWeight":null,"aminoAcidEnd":195,"aminoAcidStart":1,"nature":"Recombinant","expressionSystem":"Wheat germ","accessionNumber":"O00264","tags":[{"tag":"GST","terminus":"N-Terminus"}]}]
style
left-column

Properties and storage information

Shipped at conditions
Dry Ice
Appropriate short-term storage conditions
-80°C
Appropriate long-term storage conditions
-80°C
Aliquoting information
Upon delivery aliquot
Storage information
Avoid freeze / thaw cycle
False
style
left-column

Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

PGRMC1 also known as the Progesterone Receptor Membrane Component 1 plays several roles in cellular physiology. This protein weighs around 28 kDa and is expressed across various tissues including liver lung and kidney. Commonly found in the cell membrane PGRMC1 impacts tumor growth and development due to its role in several cellular functions like signal transduction and cholesterol metabolism.
Biological function summary

PGRMC1 interacts with other proteins to influence cell cycle regulation and apoptosis. It is part of protein complexes that include Cytochrome P450 enzymes. These complexes aid in regulating steroidogenesis and drug metabolism. PGRMC1’s involvement in lipid homeostasis and membrane trafficking suggests its significant role in maintaining cell health and function.

Pathways

PGRMC1 integrates into the mevalonate pathway influencing cholesterol synthesis and steroidogenesis. It interacts with proteins such as CYP51A1 and is involved in the Wnt signaling pathway. These interactions affect cellular growth and differentiation linking PGRMC1 to pathway regulation and cellular stress responses.

Researchers associate PGRMC1 with cancer progression and neurological disorders. Its overexpression relates to various cancers augmenting tumorigenic potential. Additionally PGRMC1’s connection to Alzheimer’s disease involves interactions with amyloid precursor proteins. These links highlight PGRMC1’s potential as a therapeutic target in these conditions.
style
left-column

Specifications

Form

Liquid

style
left-column

General info

Function

Component of a progesterone-binding protein complex (PubMed : 28396637). Binds progesterone (PubMed : 25675345). Has many reported cellular functions (heme homeostasis, interaction with CYPs). Required for the maintenance of uterine histoarchitecture and normal female reproductive lifespan (By similarity). Intracellular heme chaperone. Regulates heme synthesis via interactions with FECH and acts as a heme donor for at least some hemoproteins (PubMed : 27599036). Forms a ternary complex with TMEM97 receptor and low density lipid receptor/LDLR, which increases LDLR-mediated LDL lipoprotein internalization (PubMed : 30443021).

Sequence similarities

Belongs to the cytochrome b5 family. MAPR subfamily.

Post-translational modifications

O-glycosylated; contains chondroitin sulfate attached to Ser-54. Ser-54 is in the cytoplasmic domain but the glycosylated form was detected in urine, suggesting that the membrane-bound form is cleaved, allowing for production of a secreted form which is glycosylated.

style
left-column

Product protocols

style
left-column

Target data

Component of a progesterone-binding protein complex (PubMed : 28396637). Binds progesterone (PubMed : 25675345). Has many reported cellular functions (heme homeostasis, interaction with CYPs). Required for the maintenance of uterine histoarchitecture and normal female reproductive lifespan (By similarity). Intracellular heme chaperone. Regulates heme synthesis via interactions with FECH and acts as a heme donor for at least some hemoproteins (PubMed : 27599036). Forms a ternary complex with TMEM97 receptor and low density lipid receptor/LDLR, which increases LDLR-mediated LDL lipoprotein internalization (PubMed : 30443021).
See full target information PGRMC1
style
left-column
style
left-column
style
right-column

Product promise

We are committed to supporting your work with high-quality reagents, and we're here for you every step of the way. In the unlikely event that one of our products does not perform as expected, you're protected by our Product Promise.
For full details, please see our Terms & Conditions

Please note: All products are 'FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC OR THERAPEUTIC PROCEDURES'.

For licensing inquiries, please contact partnerships@abcam.com