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AB132526

Recombinant Human PGRMC2 protein

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Recombinant Human PGRMC2 protein is a Human Full Length protein, in the 1 to 223 aa range, expressed in Wheat germ, suitable for SDS-PAGE, ELISA, WB.

View Alternative Names

DG6, PMBP, PGRMC2, Membrane-associated progesterone receptor component 2, Progesterone membrane-binding protein, Steroid receptor protein DG6

1 Images
SDS-PAGE - Recombinant Human PGRMC2 protein (AB132526)
  • SDS-PAGE

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SDS-PAGE - Recombinant Human PGRMC2 protein (AB132526)

12.5% SDS-PAGE analysis of ab132526 stained with Coomassie Blue.

Key facts

Expression system

Wheat germ

Tags

GST tag N-Terminus

Applications

SDS-PAGE, ELISA, WB

applications

Biologically active

No

Accession

O15173

Animal free

No

Carrier free

No

Species

Human

Storage buffer

pH: 8 Constituents: 0.79% Tris HCl, 0.31% Glutathione

storage-buffer

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Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Reactivity", "Dilution Info", "Notes"] }, "values": { "SDS-PAGE": { "reactivity":"TESTED_AND_REACTS", "dilution-info":"", "notes":"<p></p>" }, "ELISA": { "reactivity":"TESTED_AND_REACTS", "dilution-info":"", "notes":"<p></p>" }, "WB": { "reactivity":"TESTED_AND_REACTS", "dilution-info":"", "notes":"<p></p>" } } }
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Sequence info

[{"sequence":"MAAGDGDVKLGTLGSGSESSNDGGSESPGDAGAAAEGGGWAAAALALLTGGGEMLLNVALVALVLLGAYRLWVRWGRRGLGAGAGAGEESPATSLPRMKKRDFSLEQLRQYDGSRNPRILLAVNGKVFDVTKGSKFYGPAGPYGIFAGRDASRGLATFCLDKDALRDEYDDLSDLNAVQMESVREWEMQFKEKYDYVGRLLKPGEEPSEYTDEEDTKDHNKQD","proteinLength":"Full Length","predictedMolecularWeight":"50.2 kDa","actualMolecularWeight":null,"aminoAcidEnd":223,"aminoAcidStart":1,"nature":"Recombinant","expressionSystem":"Wheat germ","accessionNumber":"O15173","tags":[{"tag":"GST","terminus":"N-Terminus"}]}]
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Properties and storage information

Shipped at conditions
Dry Ice
Appropriate short-term storage conditions
-80°C
Appropriate long-term storage conditions
-80°C
Aliquoting information
Upon delivery aliquot
Storage information
Avoid freeze / thaw cycle
False
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Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

PGRMC2 also known as Membrane-Associated Progesterone Receptor Component 2 is a protein that plays several roles mechanically in the cell. This protein weighs approximately 22.5 kDa and exists across various tissues including liver adipose tissue and the central nervous system. It exists in cellular membranes where it may facilitate interaction with other cellular components. This specific positioning and distribution allow PGRMC2 to modulate various signaling pathways.
Biological function summary

PGRMC2 participates in multiple cellular processes related to cell survival and metabolism. It often functions as part of larger protein complexes and interacts with other proteins affecting mitochondrial function and steroid signaling. Its biological role includes influencing mitochondrial respiration and energy homeostasis critical processes in numerous cellular functions. Researchers have discovered that PGRMC2 interacts with heme impacting vital cellular and metabolic functions.

Pathways

PGRMC2 is active in steroid hormone signaling and cellular stress response pathways. It interacts with proteins like cytochrome P450 which is significant for the metabolism of various substances and heme oxygenase which regulates the degradation of heme. These interactions highlight PGRMC2's impact on vital pathways involved in maintaining cellular stability and response mechanisms.

Researchers link PGRMC2 to metabolic conditions such as obesity and diabetes. It plays a role in lipid metabolism and energy balance both critical factors in the development of these conditions. Furthermore PGRMC2 interaction with insulin receptor substrates suggests a connection to insulin resistance a common feature of type II diabetes. Understanding PGRMC2's function and its related proteins offers potential insights into therapeutic targets for these conditions.
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Specifications

Form

Liquid

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General info

Function

Required for the maintenance of uterine histoarchitecture and normal female reproductive lifespan (By similarity). May serve as a universal non-classical progesterone receptor in the uterus (Probable). Intracellular heme chaperone required for delivery of labile, or signaling heme, to the nucleus (By similarity). Plays a role in adipocyte function and systemic glucose homeostasis (PubMed : 28111073). In brown fat, which has a high demand for heme, delivery of labile heme in the nucleus regulates the activity of heme-responsive transcriptional repressors such as NR1D1 and BACH1 (By similarity).

Sequence similarities

Belongs to the cytochrome b5 family. MAPR subfamily.

Subcellular localisation

Nucleus envelope

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Product protocols

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Target data

Required for the maintenance of uterine histoarchitecture and normal female reproductive lifespan (By similarity). May serve as a universal non-classical progesterone receptor in the uterus (Probable). Intracellular heme chaperone required for delivery of labile, or signaling heme, to the nucleus (By similarity). Plays a role in adipocyte function and systemic glucose homeostasis (PubMed : 28111073). In brown fat, which has a high demand for heme, delivery of labile heme in the nucleus regulates the activity of heme-responsive transcriptional repressors such as NR1D1 and BACH1 (By similarity).
See full target information PGRMC2
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