Recombinant Human PGRP1B protein (His-DHFR tag N-Terminus)

Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

PGRP1B also known as Peptidoglycan Recognition Protein 1B plays an important role in the immune system. This protein has a molecular mass of approximately 20 kDa. It is expressed in several tissues including the liver and spleen. Mechanically PGRP1B recognizes peptidoglycan a component of bacterial cell walls. By binding to peptidoglycan it can participate in the degradation of bacterial components helping to detect and eliminate bacterial infections.

Biological function summary

Peptidoglycan Recognition Protein 1B serves as an important player in the innate immune response. It acts as solo rather than part of a larger protein complex. By identifying peptidoglycan PGRP1B can trigger immune responses that prevent bacterial growth. This activity supports the body’s first line of defense against pathogens helping to maintain cellular integrity by neutralizing potential threats.

Pathways

Peptidoglycan Recognition Protein 1B is involved in immune signaling and inflammatory pathways. In particular PGRP1B participates in pathways like the Toll-like receptor signaling which is key for activating immune responses. This protein interacts closely with other immune TLRs which share responsibility for detecting foreign molecules and activating downstream signals necessary for mounting effective immune responses.

An imbalance or dysfunction in Peptidoglycan Recognition Protein 1B can lead to problems such as autoimmune disorders or increased susceptibility to bacterial infections. Its activities are connected to inflammatory conditions where an abnormal response could trigger chronic inflammation. PGRP1B's failure to function properly leads to issues with related proteins like NOD1 and NOD2 which are also important in recognizing bacterial components and maintaining appropriate immune responses.