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AB276686

Recombinant Human PGRP1B protein (His tag)

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Recombinant Human PGRP1B protein (His tag) is a Human Full Length protein, in the 1 to 373 aa range, expressed in HEK 293 cells, with >95%, < 1 EU/µg endotoxin level, suitable for SDS-PAGE.

View Alternative Names

PGRPIB, SBBI67, PGLYRP4, Peptidoglycan recognition protein 4, Peptidoglycan recognition protein I-beta, Peptidoglycan recognition protein intermediate beta, PGLYRPIbeta, PGRP-I-beta

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SDS-PAGE - Recombinant Human PGRP1B protein (His tag) (AB276686)
  • SDS-PAGE

Supplier Data

SDS-PAGE - Recombinant Human PGRP1B protein (His tag) (AB276686)

SDS-PAGE analysis of ab276686

Key facts

Purity

>95% SDS-PAGE

Endotoxin level

< 1 EU/µg

Expression system

HEK 293 cells

Tags

His tag C-Terminus

Applications

SDS-PAGE

applications

Biologically active

No

Accession

Q96LB8

Animal free

No

Carrier free

No

Species

Human

Storage buffer

pH: 8.5 Constituents: 0.58% Sodium chloride, 0.24% Tris

storage-buffer

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Primary Antibodies

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Proteins & Peptides

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Proteins & Peptides

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Recombinant Human GNGT1 protein (His tag N-Terminus)

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Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Reactivity", "Dilution Info", "Notes"] }, "values": { "SDS-PAGE": { "reactivity":"TESTED_AND_REACTS", "dilution-info":"", "notes":"<p></p>" } } }
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Sequence info

[{"sequence":"MLPWLLVFSALGIQAWGDSSWNKTQAKQVSEGLQYLFENISQLTEKGLPTDVSTTVSRKAWGAEAVGCSIQLTTPVNVLVIHHVPGLECHDQTVCSQRLRELQAHHVHNNSGCDVAYNFLVGDDGRVYEGVGWNIQGVHTQGYNNISLGFAFFGTKKGHSPSPAALSAMENLITYAVQKGHLSSSYVQPLLGKGENCLAPRQKTSLKKACPGVVPRSVWGARETHCPRMTLPAKYGIIIHTAGRTCNISDECRLLVRDIQSFYIDRLKSCDIGYNFLVGQDGAIYEGVGWNVQGSSTPGYDDIALGITFMGTFTGIPPNAAALEAAQDLIQCAMVKGYLTPNYLLVGHSDVARTLSPGQALYNIISTWPHFKH","proteinLength":"Full Length","predictedMolecularWeight":"40.2 kDa","actualMolecularWeight":null,"aminoAcidEnd":373,"aminoAcidStart":1,"nature":"Recombinant","expressionSystem":"HEK 293 cells","accessionNumber":"Q96LB8","tags":[{"tag":"His","terminus":"C-Terminus"}]}]
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Properties and storage information

Shipped at conditions
Ambient - Can Ship with Ice
Appropriate short-term storage conditions
-20°C
Appropriate long-term storage conditions
-20°C
Aliquoting information
Upon delivery aliquot
Storage information
Avoid freeze / thaw cycle
False
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Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

PGRP1B also known as Peptidoglycan Recognition Protein 1B plays an important role in the immune system. This protein has a molecular mass of approximately 20 kDa. It is expressed in several tissues including the liver and spleen. Mechanically PGRP1B recognizes peptidoglycan a component of bacterial cell walls. By binding to peptidoglycan it can participate in the degradation of bacterial components helping to detect and eliminate bacterial infections.
Biological function summary

Peptidoglycan Recognition Protein 1B serves as an important player in the innate immune response. It acts as solo rather than part of a larger protein complex. By identifying peptidoglycan PGRP1B can trigger immune responses that prevent bacterial growth. This activity supports the body’s first line of defense against pathogens helping to maintain cellular integrity by neutralizing potential threats.

Pathways

Peptidoglycan Recognition Protein 1B is involved in immune signaling and inflammatory pathways. In particular PGRP1B participates in pathways like the Toll-like receptor signaling which is key for activating immune responses. This protein interacts closely with other immune TLRs which share responsibility for detecting foreign molecules and activating downstream signals necessary for mounting effective immune responses.

An imbalance or dysfunction in Peptidoglycan Recognition Protein 1B can lead to problems such as autoimmune disorders or increased susceptibility to bacterial infections. Its activities are connected to inflammatory conditions where an abnormal response could trigger chronic inflammation. PGRP1B's failure to function properly leads to issues with related proteins like NOD1 and NOD2 which are also important in recognizing bacterial components and maintaining appropriate immune responses.
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Specifications

Form

Lyophilized

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General info

Function

Pattern receptor that binds to murein peptidoglycans (PGN) of Gram-positive bacteria. Has bactericidal activity towards Gram-positive bacteria. May kill Gram-positive bacteria by interfering with peptidoglycan biosynthesis. Also binds to Gram-negative bacteria, and has bacteriostatic activity towards Gram-negative bacteria. Plays a role in innate immunity.

Sequence similarities

Belongs to the N-acetylmuramoyl-L-alanine amidase 2 family.

Post-translational modifications

N-glycosylated.

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Product protocols

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Target data

Pattern receptor that binds to murein peptidoglycans (PGN) of Gram-positive bacteria. Has bactericidal activity towards Gram-positive bacteria. May kill Gram-positive bacteria by interfering with peptidoglycan biosynthesis. Also binds to Gram-negative bacteria, and has bacteriostatic activity towards Gram-negative bacteria. Plays a role in innate immunity.
See full target information PGLYRP4
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