Recombinant Human PGRPS protein - BSA and Azide free
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Recombinant Human PGRPS protein - BSA and Azide free is a Human Full Length protein, in the 22 to 196 aa range, expressed in Escherichia coli, with >90%, < 1 EU/µg endotoxin level, suitable for SDS-PAGE, ELISA, WB, Mass Spec.
View Alternative Names
PGLYRP, PGRP, TNFSF3L, SBBI68, UNQ639/PRO1269, PGLYRP1, Peptidoglycan recognition protein 1, Peptidoglycan recognition protein short, PGRP-S
- SDS-PAGE
Supplier Data
SDS-PAGE - Recombinant Human PGRPS protein - BSA and Azide free (AB175469)
14% SDS-PAGE analysis of ab175469
Lane 1 : reduced and heated sample (2.5 μg)
Lane 2 : Non-reduced and non-heated sample (2.5 μg)
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Reactivity data
Sequence info
Properties and storage information
Shipped at conditions
Appropriate short-term storage conditions
Appropriate long-term storage conditions
Storage information
Supplementary information
This supplementary information is collated from multiple sources and compiled automatically.
Biological function summary
Functioning in innate immunity PGRPs bind to bacterial cell wall components such as peptidoglycan and lipopolysaccharides. When PGRPs detect these molecules they can activate immune responses to neutralize pathogens. Some PGRPs can also act as amidases breaking down peptidoglycans. PGRPs do not usually act alone; they are part of complexes with other immune proteins to enhance pathogen recognition and response.
Pathways
PGRPs play significant roles in the immune pathway and inflammatory signaling pathways. They interact with the toll-like receptor pathways to mediate responses to bacterial infections. PGRPs also link with Nod proteins to modulate the immune response upon detecting peptidoglycans. These pathways help coordinate an effective defense against infection.
Specifications
Form
Lyophilized
Additional notes
ab175469 was purifed using Ni-NTA chromatography.
General info
Function
Innate immunity protein that plays several important functions in antimicrobial and antitumor defense systems. Acts as a pattern receptor that binds to murein peptidoglycans (PGN) of Gram-positive bacteria and thus provides bactericidal activity (PubMed : 9707603). Forms an equimolar complex with heat shock protein HSPA1A and induces programmed cell death through apoptosis and necroptosis in tumor cell lines by activating the TNFR1 receptor on the target cell membrane (PubMed : 21247889, PubMed : 26183779). In addition, acts in complex with the Ca(2+)-binding protein S100A4 as a chemoattractant able to induce lymphocyte movement (PubMed : 26654597). Mechanistically, this complex acts as a ligand of the chemotactic receptors CCR5 and CXCR3 which are present on the cells of the immune system (PubMed : 30713770). Also promotes the activation of lymphocytes that become able to kill virus-infected cells as well as tumor cells by modulating the spectrum of their target-cell specificity (PubMed : 28977785, PubMed : 29083508). Induction of cytotoxicity on monocyte surface requires interaction with TREM1 receptor (PubMed : 25595774, PubMed : 28977785).
Sequence similarities
Belongs to the N-acetylmuramoyl-L-alanine amidase 2 family.
Post-translational modifications
N-glycosylated. N-glycosylation is required for bactericidal activity.
Target data
Product promise
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