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AB136352

Recombinant Human PHF11 protein (denatured) (His tag N-Terminus)

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Recombinant Human PHF11 protein (denatured) (His tag N-Terminus) is a Human Full Length protein, in the 1 to 331 aa range, expressed in Escherichia coli, with >85%, suitable for SDS-PAGE.

View Alternative Names

BCAP, PHF11, PHD finger protein 11, BRCA1 C-terminus-associated protein, Renal carcinoma antigen NY-REN-34

1 Images
SDS-PAGE - Recombinant Human PHF11 protein (denatured) (His tag N-Terminus) (AB136352)
  • SDS-PAGE

Unknown

SDS-PAGE - Recombinant Human PHF11 protein (denatured) (His tag N-Terminus) (AB136352)

15% SDS-PAGE analysis of ab136352 (3 μg)

Key facts

Purity

>85% SDS-PAGE

Expression system

Escherichia coli

Tags

His tag N-Terminus

Applications

SDS-PAGE

applications

Biologically active

No

Accession

Q9UIL8

Animal free

No

Carrier free

No

Species

Human

Storage buffer

pH: 8 Constituents: 10% Glycerol (glycerin, glycerine), 2.4% Urea, 0.32% Tris HCl

storage-buffer

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Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Reactivity", "Dilution Info", "Notes"] }, "values": { "SDS-PAGE": { "reactivity":"TESTED_AND_REACTS", "dilution-info":"", "notes":"<p></p>" } } }
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Sequence info

[{"sequence":"MGSSHHHHHHSSGLVPRGSHMAQASPPRPERVLGASSPEARPAQEALLLPTGVFQVAEKMEKRTCALCPKDVEYNVLYFAQSENIAAHENCLLYSSGLVECEDQDPLNPDRSFDVESVKKEIQRGRKLKCKFCHKRGATVGCDLKNCNKNYHFFCAKKDDAVPQSDGVRGIYKLLCQQHAQFPIIAQSAKFSGVKRKRGRKKPLSGNHVQPPETMKCNTFIRQVKEEHGRHTDATVKVPFLKKCKEAGLLNYLLEEILDKVHSIPEKLMDETTSESDYEEIGSALFDCRLFEDTFVNFQAAIEKKIHASQQRWQQLKEEIELLQDLKQTLCSFQENRDLMSSSTSISSLSY","proteinLength":"Full Length","predictedMolecularWeight":"39.7 kDa","actualMolecularWeight":null,"aminoAcidEnd":331,"aminoAcidStart":1,"nature":"Recombinant","expressionSystem":"Escherichia coli","accessionNumber":"Q9UIL8","tags":[{"tag":"His","terminus":"N-Terminus"}]}]
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Properties and storage information

Shipped at conditions
Blue Ice
Appropriate short-term storage duration
1-2 weeks
Appropriate short-term storage conditions
+4°C
Appropriate long-term storage conditions
-20°C
Aliquoting information
Upon delivery aliquot
Storage information
Avoid freeze / thaw cycle
False
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Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

PHF11 also known as PHD finger protein 11 is a protein encoded by the PHF11 gene in humans. This protein has a molecular mass of approximately 32 kDa. It is expressed in various tissues with a higher concentration in lymphoid tissues like the thymus and spleen. PHF11 contains PHD zinc finger domains which suggest its involvement in chromatin remodeling activities. These structures enable the protein to interact with histones influencing gene transcription processes.
Biological function summary

PHF11 regulates the immune response and chromatin-mediated transcription. Its role involves influencing the accessibility of chromatin for transcriptional machinery aiding in gene expression modulation. Although it primarily functions alone PHF11 can also associate with chromatin remodeling complexes to fulfill its role in transcription regulation. It contributes to cytokine expression impacting immune response modulation which is critical for organismal defense mechanisms.

Pathways

PHF11 participates in immune response pathways including the adaptive immune response. It interacts with other proteins in these pathways such as transcription factors and histones to mediate transcription of immune-related genes. An important relationship exists with proteins involved in the NF-kB signaling pathway which is essential for immune and inflammatory responses. Through its interactions PHF11 helps fine-tune immune gene activation and contributes to balancing immune signaling.

PHF11 exhibits associations with asthma and allergic rhinitis. Researchers have observed that alterations in PHF11 expression can influence susceptibility and severity of these conditions. This protein influences immune pathways that involve other proteins such as cytokines which affect immune cell recruitment and inflammation. Studies suggest PHF11 as a potential therapeutic target for modulating immune responses in these disorders providing pathways for intervention and therapy development.
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Specifications

Form

Liquid

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General info

Function

Positive regulator of Th1-type cytokine gene expression.

Subcellular localisation

Nucleus

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Product protocols

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Target data

Positive regulator of Th1-type cytokine gene expression.
See full target information PHF11
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Complementary Products

Cell Lines & Lysates

AB258578

Human PHF11 knockout A549 cell lysate

Sanger Sequencing - Human PHF11 knockout A549 cell lysate (AB258578)

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