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AB164987

Recombinant Human PHF21B protein (GST tag N-Terminus)

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Recombinant Human PHF21B protein (GST tag N-Terminus) is a Human Full Length protein, in the 1 to 531 aa range, expressed in Wheat germ, suitable for ELISA, WB.

View Alternative Names

KIAA1661, PHF21B, PHD finger protein 21B

1 Images
SDS-PAGE - Recombinant Human PHF21B protein (GST tag N-Terminus) (AB164987)
  • SDS-PAGE

Unknown

SDS-PAGE - Recombinant Human PHF21B protein (GST tag N-Terminus) (AB164987)

ab164987 on a 12.5% SDS-PAGE stained with Coomassie Blue.

Key facts

Expression system

Wheat germ

Tags

GST tag N-Terminus

Applications

WB, ELISA

applications

Biologically active

No

Accession

Q96EK2

Animal free

No

Carrier free

No

Species

Human

Storage buffer

pH: 8 Constituents: 0.79% Tris HCl, 0.31% Glutathione

storage-buffer

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Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Reactivity", "Dilution Info", "Notes"] }, "values": { "ELISA": { "reactivity":"TESTED_AND_REACTS", "dilution-info":"", "notes":"<p></p>" }, "WB": { "reactivity":"TESTED_AND_REACTS", "dilution-info":"", "notes":"<p></p>" } } }
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Sequence info

[{"sequence":"MELQSRPEALAVELARHQNGDLKKQLHERQPRIAALSDKQALGTITAVPVTGPQVSSLQRLAGQGAAVLPQVRPKTLIPDSLPVAPGRDRPPKQPPTFQKATVVSVKNPSPALPTANNTVSHVPAPGSQPQALAEPAALASPLSSAGVAYAIISTSPSNAAAMAPSTAVSVVSDSIKVQPLLISADNKPPPRLLSSPHPATHHCPLHPSSLPLTPPSPSLSPSPLHGIFQVIIIQPQVQTQPESTAESRPPTEEPSQGAQATKKKKEDRPPTQENPEKIAFMVALGLVTTEHLEEIQSKRQERKRRSTANPAYSGLLETERKRLASNYLNNPLFLTARANEDPCWKNEITHDEHCAACKRGANLQPCGTCPGAYHLSCLEPPLKTAPKGVWVCPRCQQKALKKDEGVPWTGMLAIVHSYVTHKTVKEEEKQKLLQRGSELQNEHQQLEERDRRLASAVQKCLELKTSLLARQRGTQSSLDRLRALLRLIQGEQLLQVTMTTTSPAPLLAGPWTKPSVAATHPTVQHPQGHN","proteinLength":"Full Length","predictedMolecularWeight":null,"actualMolecularWeight":null,"aminoAcidEnd":531,"aminoAcidStart":1,"nature":"Recombinant","expressionSystem":"Wheat germ","accessionNumber":"Q96EK2","tags":[{"tag":"GST","terminus":"N-Terminus"}]}]
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Properties and storage information

Shipped at conditions
Dry Ice
Appropriate short-term storage conditions
-80°C
Appropriate long-term storage conditions
-80°C
Aliquoting information
Upon delivery aliquot
Storage information
Avoid freeze / thaw cycle
False
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Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

PHF21B also referred to as plant homeodomain finger protein 21B acts mechanically as a transcriptional repressor. It contains a PHD domain which helps it bind to specific histone modifications. The protein has an estimated mass of approximately 73 kDa. Expression of PHF21B occurs in various tissues particularly within the brain and pancreas indicating its potential significance in neurological and metabolic functions.
Biological function summary

PHF21B functions as an integral component of chromatin remodeling complexes that influence gene expression. By modulating chromatin architecture PHF21B participates in regulating accessibility of DNA to transcription factors thereby influencing transcriptional activity. It's a part of larger protein complexes but specific interactions with co-factors or complex components might involve various proteins that bind to modified histones impacting gene silencing efficiently.

Pathways

Several studies suggest that PHF21B is active in epigenetic regulation pathways mainly affecting histone modification pathways. It influences gene expression by altering the epigenetic landscape and interacts with proteins like HDACs and other histone methylation-related proteins. Additionally PHF21B is thought to influence neuron development pathways further supported by its expression in brain tissue where it partners with neurodevelopment-related proteins.

Research implicates PHF21B modifications in neurological disorders including neurodevelopmental delays and certain intellectual disabilities. Variants in PHF21B relate to autism spectrum disorders suggesting its role in synapse formation or maintenance may be important. Additionally misregulation of genes involving PHF21B and its interaction partners such as MECP2 may contribute to understanding complex genetic pathologies linked to neural development issues.
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Specifications

Form

Liquid

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General info

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Product protocols

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Target data

See full target information PHF21B
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Product promise

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