Recombinant human PHKG1 protein
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Recombinant human PHKG1 protein is a Human Full Length protein, in the 1 to 387 aa range, expressed in Baculovirus, with >75%, suitable for SDS-PAGE, FuncS.
View Alternative Names
PHKG, PHKG1, PHK-gamma-M, Phosphorylase kinase subunit gamma-1, Serine/threonine-protein kinase PHKG1
- FuncS
Unknown
Functional Studies - Recombinant human PHKG1 protein (AB101715)
The specific activity of ab101715 was determined to be 29 nmol/min/mg.
- FuncS
Unknown
Functional Studies - Recombinant human PHKG1 protein (AB101715)
The specific activity of PHKG1 (ab101715) was determined to be 26 nmol/min/mg as per activity assay protocol
- SDS-PAGE
Unknown
SDS-PAGE - Recombinant human PHKG1 protein (AB101715)
The putity of ab101715 was determined to be 75% by densitometry.
Approximate MWt : 70kDa
- SDS-PAGE
Unknown
SDS-PAGE - Recombinant human PHKG1 protein (AB101715)
SDS PAGE analysis of ab101715
Reactivity data
Product details
Sequence info
Properties and storage information
Shipped at conditions
Appropriate short-term storage conditions
Appropriate long-term storage conditions
Aliquoting information
Storage information
Supplementary information
This supplementary information is collated from multiple sources and compiled automatically.
Biological function summary
PHKG1 acts as a critical component of the larger phosphorylase kinase complex. This complex promotes glycogenolysis the process of converting glycogen to glucose-1-phosphate facilitating energy release in cells. Within tissues PHKG1 interacts with other subunits of phosphorylase kinase playing a regulatory role. Effective activation of phosphorylase b to active phosphorylase a form relies on efficient PHKG1 function.
Pathways
PHKG1 is essential in the glycogenolysis pathway. It interacts with AMP-activated protein kinase (AMPK). Besides PHKG1 associates with cAMP-dependent protein kinase (PKA) as both enzymes participate in regulating energy homeostasis. These interactions highlight the enzyme’s function in maintaining metabolic balance under stress conditions.
Specifications
Form
Liquid
Additional notes
Affinity purified.
General info
Function
Catalytic subunit of the phosphorylase b kinase (PHK), which mediates the neural and hormonal regulation of glycogen breakdown (glycogenolysis) by phosphorylating and thereby activating glycogen phosphorylase. In vitro, phosphorylates PYGM, TNNI3, MAPT/TAU, GAP43 and NRGN/RC3 (By similarity).
Sequence similarities
Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family.
Target data
Complementary Products
Product promise
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