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AB235615

Recombinant Human PHO1 protein (Tagged)

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Recombinant Human PHO1 protein (Tagged) is a Human Full Length protein, in the 1 to 199 aa range, expressed in Escherichia coli, with >90%, suitable for SDS-PAGE.

View Alternative Names

DNA dC->dU-editing enzyme APOBEC-3A, A3A, Phorbolin-1, APOBEC3A

1 Images
SDS-PAGE - Recombinant Human PHO1 protein (Tagged) (AB235615)
  • SDS-PAGE

Supplier Data

SDS-PAGE - Recombinant Human PHO1 protein (Tagged) (AB235615)

ab235615 analyzed by (Tris-Glycine gel) discontinuous SDS-PAGE (reduced) with 5% enrichment gel and 15% separation gel.

Key facts

Purity

>90% SDS-PAGE

Expression system

Escherichia coli

Tags

6x His tag N-Terminus SUMO tag N-Terminus

Applications

SDS-PAGE

applications

Biologically active

No

Accession

P31941

Animal free

No

Carrier free

No

Species

Human

Storage buffer

pH: 7.2 - 7.4 Constituents: Tris buffer, 50% Glycerol (glycerin, glycerine)

storage-buffer

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Primary Antibodies

AB184990

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Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Reactivity", "Dilution Info", "Notes"] }, "values": { "SDS-PAGE": { "reactivity":"TESTED_AND_REACTS", "dilution-info":"", "notes":"<p></p>" } } }
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Sequence info

[{"linker":null,"sequence":"MEASPASGPRHLMDPHIFTSNFNNGIGRHKTYLCYEVERLDNGTSVKMDQHRGFLHNQAKNLLCGFYGRHAELRFLDLVPSLQLDPAQIYRVTWFISWSPCFSWGCAGEVRAFLQENTHVRLRIFAARIYDYDPLYKEALQMLRDAGAQVSIMTYDEFKHCWDTFVDHQGCPFQPWDGLDEHSQALSGRLRAILQNQGN","proteinLength":"Full Length","predictedMolecularWeight":"39 kDa","actualMolecularWeight":null,"aminoAcidEnd":199,"aminoAcidStart":1,"nature":"Recombinant","expressionSystem":"Escherichia coli","accessionNumber":"P31941","tags":[{"tag":"6x His","terminus":"N-Terminus"},{"tag":"SUMO","terminus":"N-Terminus"}]}]
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Properties and storage information

Form
Liquid
Shipped at conditions
Blue Ice
Appropriate short-term storage conditions
-20°C
Appropriate long-term storage conditions
-20°C
Storage information
Avoid freeze / thaw cycle
False
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Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

PHO1 also known as phosphate transporter 1 is a protein involved in the transport of phosphate across membranes. It has a molecular mass of approximately 86 kDa and is expressed significantly in the vascular tissues of plants especially in roots and shoots. This transporter functions by facilitating the efflux of phosphate into the xylem which enables the mobilization of phosphate from roots to aerial parts of the plant.
Biological function summary

PHO1 plays a critical role in maintaining phosphate homeostasis within the plant system. The protein works in coordination with other phosphate transport components as part of the phosphate transport complex. By regulating phosphate distribution PHO1 ensures optimal nutrient availability which is essential for various cellular and metabolic processes including energy transfer signaling and nucleic acid synthesis.

Pathways

PHO1 is an integral component of the phosphate signaling and homeostasis pathways. It interacts with proteins like PHR1 (Phosphate Starvation Response 1) which acts as a transcription factor that regulates the expression of phosphate-responsive genes. Additionally PHO1 plays a role in the systemic signaling pathway that links soil nutrient availability to shoot nutrient processes providing feedback for phosphate uptake from the environment.

PHO1 alterations relate to phosphate deficiency conditions which can impact plant growth and agriculture productivity. The protein's malfunction could lead to disorders in plants similar to nutritional deficiencies reducing crop yield and health. Interestingly similar pathways involve proteins like PHO2 that control phosphate uptake further demonstrating the interconnected network that PHO1 is part of in maintaining nutrient balance.
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General info

Function

DNA deaminase (cytidine deaminase) with restriction activity against viruses, foreign DNA and mobility of retrotransposons. Exhibits antiviral activity against adeno-associated virus (AAV) and human T-cell leukemia virus type 1 (HTLV-1) and may inhibit the mobility of LTR and non-LTR retrotransposons. Selectively targets single-stranded DNA and can deaminate both methylcytosine and cytosine in foreign DNA. Can induce somatic hypermutation in the nuclear and mitochondrial DNA. May also play a role in the epigenetic regulation of gene expression through the process of active DNA demethylation.

Sequence similarities

Belongs to the cytidine and deoxycytidylate deaminase family.

Subcellular localisation

Nucleus

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Product protocols

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Target data

DNA deaminase (cytidine deaminase) with restriction activity against viruses, foreign DNA and mobility of retrotransposons. Exhibits antiviral activity against adeno-associated virus (AAV) and human T-cell leukemia virus type 1 (HTLV-1) and may inhibit the mobility of LTR and non-LTR retrotransposons. Selectively targets single-stranded DNA and can deaminate both methylcytosine and cytosine in foreign DNA. Can induce somatic hypermutation in the nuclear and mitochondrial DNA. May also play a role in the epigenetic regulation of gene expression through the process of active DNA demethylation.
See full target information APOBEC3A
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