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AB116206

Recombinant Human PHOSPHO2 protein

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Recombinant Human PHOSPHO2 protein is a Human Full Length protein, in the 1 to 241 aa range, expressed in Escherichia coli, with >85%, suitable for SDS-PAGE, Mass Spec.

View Alternative Names

Pyridoxal phosphate phosphatase PHOSPHO2, PHOSPHO2

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SDS-PAGE - Recombinant Human PHOSPHO2 protein (AB116206)
  • SDS-PAGE

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SDS-PAGE - Recombinant Human PHOSPHO2 protein (AB116206)

15% SDS-PAGE analysis of 3 µg ab116206.

Key facts

Purity

>85% SDS-PAGE

Expression system

Escherichia coli

Tags

His tag N-Terminus

Applications

Mass Spec, SDS-PAGE

applications

Biologically active

No

Accession

Q8TCD6

Animal free

No

Carrier free

No

Species

Human

Storage buffer

pH: 8 Constituents: 10% Glycerol (glycerin, glycerine), 0.58% Sodium chloride, 0.32% Tris HCl, 0.02% (R*,R*)-1,4-Dimercaptobutan-2,3-diol

storage-buffer

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Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Reactivity", "Dilution Info", "Notes"] }, "values": { "SDS-PAGE": { "reactivity":"TESTED_AND_REACTS", "dilution-info":"", "notes":"<p></p>" }, "Mass Spec": { "reactivity":"TESTED_AND_REACTS", "dilution-info":"", "notes":"<p></p>" } } }
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Sequence info

[{"sequence":"MGSSHHHHHHSSGLVPRGSHMGSHMKILLVFDFDNTIIDDNSDTWIVQCAPNKKLPIELRDSYRKGFWTEFMGRVFKYLGDKGVREHEMKRAVTSLPFTPGMVELFNFIRKNKDKFDCIIISDSNSVFIDWVLEAASFHDIFDKVFTNPAAFNSNGHLTVENYHTHSCNRCPKNLCKKVVLIEFVDKQLQQGVNYTQIVYIGDGGNDVCPVTFLKNDDVAMPRKGYTLQKTLSRMSQNLEPMEYSVVVWSSGVDIISHLQFLIKD","proteinLength":"Full Length","predictedMolecularWeight":"30.3 kDa","actualMolecularWeight":null,"aminoAcidEnd":241,"aminoAcidStart":1,"nature":"Recombinant","expressionSystem":"Escherichia coli","accessionNumber":"Q8TCD6","tags":[{"tag":"His","terminus":"N-Terminus"}]}]
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Properties and storage information

Shipped at conditions
Blue Ice
Appropriate short-term storage duration
1-2 weeks
Appropriate short-term storage conditions
+4°C
Appropriate long-term storage conditions
-20°C
Aliquoting information
Upon delivery aliquot
Storage information
Avoid freeze / thaw cycle
False
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Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

PHOSPHO2 also known as Phosphatase Orphan 2 is a protein that functions mechanically as a phosphatase involved in removing phosphate groups from substrates. This protein has an approximate mass of 31 kDa. PHOSPHO2 is expressed in various tissues including the liver and kidney where it acts in regulating phosphorylation states important for cellular function.
Biological function summary

The activity of PHOSPHO2 significantly impacts several cellular processes. It is not known to be part of any substantial complexes. Its enzymatic activity regulates the phosphorylation of proteins this is important for signal transduction and cellular communication. By modulating phosphoproteins PHOSPHO2 ensures balanced cellular activities like response to environmental stimuli.

Pathways

PHOSPHO2 participates in or influences the phosphate metabolism pathway and plays a role in regulatory networks that control signaling pathways. It interacts with other proteins such as phosphoproteins in these pathways. While further research is needed to elucidate its exact partners fully PHOSPHO2's function in phosphorylation suggests general interactions with a variety of signaling proteins within these biological pathways.

There is evidence suggesting a link between PHOSPHO2 activity and metabolic disorders like diabetes. Abnormal regulation of phosphorylation can lead to improper signal transduction contributing to disease pathogenesis. PHOSPHO2 also shares a functional relationship with other phosphatases like PPM1A in these conditions which collectively affects metabolic homeostasis. Understanding these connections may help in developing therapeutic strategies targeting metabolic dysfunctions.
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Specifications

Form

Liquid

Additional notes

ab116206 was purified using conventional chromatography techniques.

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General info

Function

Phosphatase that has high activity toward pyridoxal 5'-phosphate (PLP). Also active at much lower level toward pyrophosphate, phosphoethanolamine (PEA), phosphocholine (PCho), phospho-l-tyrosine, fructose-6-phosphate, p-nitrophenyl phosphate, and h-glycerophosphate.

Sequence similarities

Belongs to the HAD-like hydrolase superfamily. PHOSPHO family.

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Product protocols

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Target data

Phosphatase that has high activity toward pyridoxal 5'-phosphate (PLP). Also active at much lower level toward pyrophosphate, phosphoethanolamine (PEA), phosphocholine (PCho), phospho-l-tyrosine, fructose-6-phosphate, p-nitrophenyl phosphate, and h-glycerophosphate.
See full target information PHOSPHO2
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