Recombinant human PI4 kinase beta/PI4KB protein (Active)
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Recombinant human PI4 kinase beta/PI4KB protein (Active) is a Human Full Length protein, expressed in Baculovirus infected Sf9 cells, with >70%, suitable for SDS-PAGE, FuncS.
View Alternative Names
PIK4CB, PI4KB, Phosphatidylinositol 4-kinase beta, PI4K-beta, PI4Kbeta, PtdIns 4-kinase beta, NPIK, PI4K92, PI4KIII
- FuncS
Supplier Data
Functional Studies - Recombinant human PI4 kinase beta/PI4KB protein (Active) (AB268863)
The specific activity of ab268863 was 5,395 nmol/min/mg in a kinase assay using PI : PS as substrate.
- SDS-PAGE
Supplier Data
SDS-PAGE - Recombinant human PI4 kinase beta/PI4KB protein (Active) (AB268863)
SDS-PAGE analysis of ab268863.
Reactivity data
Sequence info
Properties and storage information
Shipped at conditions
Appropriate short-term storage conditions
Appropriate long-term storage conditions
Aliquoting information
Storage information
Supplementary information
This supplementary information is collated from multiple sources and compiled automatically.
Biological function summary
The enzyme plays a role in maintaining proper intracellular membrane structure and function. It operates as part of a larger complex involving additional elements such as the small GTPase ARF1 and the scaffold protein ACBD3 which are necessary for its recruitment and activity at Golgi membranes. PI4KB facilitates vesicular trafficking and supplies substrates for the production of other phosphoinositides impacting diverse cellular events like cell growth and signal transduction.
Pathways
PI4KB is an important participant in the phosphoinositide signaling pathway. This pathway regulates membrane dynamics and trafficking influencing cell signaling and membrane identity. PI4KB interacts with proteins such as PI4K2A and PI4K2B in the synthesis of different phosphoinositides which are components of the signaling cascade that include PI3K/AKT pathway having implications in cell growth and survival.
Specifications
Form
Liquid
Additional notes
Affinity purified.
General info
Function
Phosphorylates phosphatidylinositol (PI) in the first committed step in the production of the second messenger inositol-1,4,5,-trisphosphate (PIP). May regulate Golgi disintegration/reorganization during mitosis, possibly via its phosphorylation. Involved in Golgi-to-plasma membrane trafficking (By similarity) (PubMed : 10559940, PubMed : 11277933, PubMed : 12749687, PubMed : 9405935). May play an important role in the inner ear development.. (Microbial infection) Plays an essential role in Aichi virus RNA replication (PubMed : 22124328, PubMed : 22258260, PubMed : 27989622). Recruited by ACBD3 at the viral replication sites (PubMed : 22124328, PubMed : 27989622).. (Microbial infection) Required for cellular spike-mediated entry of human coronavirus SARS-CoV.
Sequence similarities
Belongs to the PI3/PI4-kinase family. Type III PI4K subfamily.
Subcellular localisation
Mitochondrion outer membrane
Target data
Complementary Products
Product promise
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