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AB187487

Recombinant Human PIH1D2 protein (His tag N-Terminus)

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Recombinant Human PIH1D2 protein (His tag N-Terminus) is a Human Full Length protein, in the 1 to 315 aa range, expressed in Escherichia coli, with >85%, suitable for SDS-PAGE, Mass Spec.

View Alternative Names

PIH1 domain-containing protein 2, PIH1D2

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SDS-PAGE - Recombinant Human PIH1D2 protein (AB187487)
  • SDS-PAGE

Supplier Data

SDS-PAGE - Recombinant Human PIH1D2 protein (AB187487)

15% SDS-PAGE analysis of ab187487 (3 μg).

Key facts

Purity

>85% SDS-PAGE

Expression system

Escherichia coli

Tags

His tag N-Terminus

Applications

Mass Spec, SDS-PAGE

applications

Biologically active

No

Accession

Q8WWB5

Animal free

No

Carrier free

No

Species

Human

Storage buffer

pH: 7.4 Constituents: PBS, 20% Glycerol (glycerin, glycerine), 0.02% (R*,R*)-1,4-Dimercaptobutan-2,3-diol

storage-buffer

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Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Reactivity", "Dilution Info", "Notes"] }, "values": { "SDS-PAGE": { "reactivity":"TESTED_AND_REACTS", "dilution-info":"", "notes":"<p></p>" }, "Mass Spec": { "reactivity":"TESTED_AND_REACTS", "dilution-info":"", "notes":"<p></p>" } } }
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Sequence info

[{"sequence":"MGSSHHHHHHSSGLVPRGSHMGSMETSSKGLLTQVTQFWNLLDDLAQSDPEGYEKFIQQQLKEGKQLCAAPEPQLCLQTRILKPKEKILFINLCQWTRIPAPQSTTHPVPLTVGKPEDTTEISDAYTVIDVAYNPDVLHAAEKDQVKKNQLIQMAMKCIEEKFQFTLSHSYHITKFRIKGSIQRMKQNLMGIQTDSIDLREKMRRELTLGQIRSSTMSNPDHFPQLLLPKDQVSGKAVCLIEEISSTEIQVEMKMPAYELKIVHDHSEKPLKIELKVELPGINSVSLCDLSVSEDDLLIEVSEKYRLHLNLPKLIDTEMTTAKFIKEKSTLIITMPLV","proteinLength":"Full Length","predictedMolecularWeight":"38.3 kDa","actualMolecularWeight":null,"aminoAcidEnd":315,"aminoAcidStart":1,"nature":"Recombinant","expressionSystem":"Escherichia coli","accessionNumber":"Q8WWB5","tags":[{"tag":"His","terminus":"N-Terminus"}]}]
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Properties and storage information

Shipped at conditions
Blue Ice
Appropriate short-term storage duration
1-2 weeks
Appropriate short-term storage conditions
+4°C
Appropriate long-term storage conditions
-20°C
Aliquoting information
Upon delivery aliquot
Storage information
Avoid freeze / thaw cycle
False
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Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

PIH1D2 also known as Protein Interacting with HSP90 1D2 is a protein encoded by the PIH1D2 gene. It has a molecular mass of approximately 34 kDa. This protein is expressed in various tissues with notable expression in the testis and among cell lines derived from different human cancers. PIH1D2 is part of the R2TP complex which is involved in the assembly and stabilization of protein complexes within cells.
Biological function summary

PIH1D2 functions as a component of the R2TP complex which collaborates with the HSP90 chaperone machinery. This complex assists in the assembly and maintenance of complex protein structures including RNA polymerase complexes and small nucleolar ribonucleoproteins. PIH1D2 contributes to the stabilization of these protein structures facilitating proper cellular function and survival under stressful conditions.

Pathways

PIH1D2 plays roles in processes related to the assembly of RNA polymerase II and snoRNPs assembly pathways. It interacts with other proteins such as RPAP3 and HSP90. Through these interactions PIH1D2 aids in the complex formation and ensures the correct function of these biological pathways which are fundamental for transcriptional regulation and RNA processing.

Alterations in the function of PIH1D2 may link to cancer progression and neurological disorders. Specifically its involvement in protein assembly and RNA polymerase complexes indicates a connection to tumor growth and potentially neurodegenerative conditions. PIH1D2's interaction with the HSP90 protein chaperone highlights its importance in these disease contexts as HSP90 is recognized for its role in cancer cell proliferation and survival.
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Specifications

Form

Liquid

Additional notes

ab187487 was purified using conventional chromatography techniques.

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General info

Sequence similarities

Belongs to the PIH1 family.

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Product protocols

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Target data

See full target information PIH1D2
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