Recombinant human PIK3C2G protein (Active)
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Recombinant human PIK3C2G protein (Active) is a Human Fragment protein, in the 468 to 1203 aa range, expressed in Baculovirus infected Sf9 cells, with >80%, suitable for SDS-PAGE, FuncS.
View Alternative Names
Phosphatidylinositol 3-kinase C2 domain-containing subunit gamma, PI3K-C2-gamma, PtdIns-3-kinase C2 subunit gamma, Phosphoinositide 3-kinase-C2-gamma, PIK3C2G
- FuncS
Supplier Data
Functional Studies - Recombinant human PIK3C2G protein (Active) (AB268866)
The specific activity of ab268866 was 5,000 nmol/min/mg in a kinase assay using PI : PS as substrate.
- SDS-PAGE
Supplier Data
SDS-PAGE - Recombinant human PIK3C2G protein (Active) (AB268866)
SDS-PAGE analysis of ab268866.
Reactivity data
Sequence info
Properties and storage information
Shipped at conditions
Appropriate short-term storage conditions
Appropriate long-term storage conditions
Aliquoting information
Storage information
Supplementary information
This supplementary information is collated from multiple sources and compiled automatically.
Biological function summary
The protein PIK3C2G contributes to cell functions involving membrane trafficking and signal transduction. The protein performs its duties partly by participating in the formation of lipid signaling molecules. It does not generally form a stable complex with other proteins differentiating it from class I PI3Ks that typically form heterodimers. Instead PIK3C2G's activity strongly contributes to cellular tasks like the regulation of endocytosis and exocytosis processes critical for maintaining cellular homeostasis.
Pathways
PIK3C2G interacts within the phosphatidylinositol signaling pathway by regulating the synthesis of phosphorylated phosphatidylinositols. It serves a significant role alongside proteins like PIK3C2A and PIK3C2B in modulating intracellular signals. These activities relate closely to the AKT signaling pathway which controls cell growth and survival. PIK3C2G's position in these pathways is essential as it directly impacts how cells respond to external stimuli such as growth factors and hormones.
Specifications
Form
Liquid
Additional notes
Affinity purified.
General info
Function
Generates phosphatidylinositol 3-phosphate (PtdIns3P) and phosphatidylinositol 3,4-bisphosphate (PtdIns(3,4)P2) that act as second messengers (By similarity). May play a role in SDF1A-stimulated chemotaxis (By similarity).
Sequence similarities
Belongs to the PI3/PI4-kinase family.
Target data
Complementary Products
Product promise
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