Recombinant Human PIK3IP1 protein is a Human Fragment protein, in the 22 to 168 aa range, expressed in Mammalian, with >95% purity, < 1 EU/µg endotoxin level and suitable for SDS-PAGE, HPLC.
S G G C F W D N G H L Y R E D Q T S P A P G L R C L N W L D A Q S G L A S A P V S G A G N H S Y C R N P D E D P R G P W C Y V S G E A G V P E K R P C E D L R C P E T T S Q A L P A F T T E I Q E A S E G P G A D E V Q V F A P A N A L P A R S E A A A V Q P V I G I S Q R V R M N S K E K K D L G T V D H H H H H H
| Application | Reactivity | Dilution info | Notes |
|---|---|---|---|
Application SDS-PAGE | Reactivity Reacts | Dilution info - | Notes - |
Application HPLC | Reactivity Reacts | Dilution info - | Notes - |
Negative regulator of hepatic phosphatidylinositol 3-kinase (PI3K) activity.
HGFL, PIK3IP1, Phosphoinositide-3-kinase-interacting protein 1, PI3K-interacting protein 1, Kringle domain-containing protein HGFL
Recombinant Human PIK3IP1 protein is a Human Fragment protein, in the 22 to 168 aa range, expressed in Mammalian, with >95% purity, < 1 EU/µg endotoxin level and suitable for SDS-PAGE, HPLC.
pH: 8
Constituents: 0.79% Tris HCl, 0.31% Glutathione
Determined by SEC-HPLC and reducing SDS-PAGE.
Negative regulator of hepatic phosphatidylinositol 3-kinase (PI3K) activity.
N- and O-glycosylated. O-glycosylated with core 1 or possibly core 8 glycans. N-glycan heterogeneity at Asn-66: dHex1Hex5HexNAc4 (major) and dHex1Hex6HexNAc5 (minor).
Dissolve the lyophilized protein in 3X PBS. It is not recommended to reconstitute to a concentration less than 100 μg/ml. Always centrifuge tubes before opening. Do not mix by vortex or pipetting.
Reconstituted protein should be aliquoted and stored at < -20°C.
PIK3IP1 also known as phosphoinositide-3-kinase-interacting protein 1 plays an important role in regulating PI3K (phosphoinositide 3-kinase) activity. It is an inhibitory molecule that modulates PI3K signaling. This protein has a molecular mass of approximately 24 kDa. PIK3IP1 expression occurs mainly in the liver and other tissues such as the spleen and lung.
PIK3IP1 serves as a negative regulator in PI3K signaling impacting cell growth and survival. It is not part of a larger complex but interacts directly with components of the PI3K pathway. Its regulation impacts cell processes by modulating one of the main pathways controlling cellular proliferation and survival.
PIK3IP1 plays an inhibitory role in the PI3K/AKT/mTOR pathway which is essential in regulating cell proliferation and metabolism. This pathway involves proteins like AKT and mTOR which contribute to cell growth and survival regulation. By inhibiting PI3K PIK3IP1 affects the downstream signaling of AKT and mTOR therefore also impacting other related pathways involved in metabolic processes.
PIK3IP1 has associations with cancer and metabolic disorders. Dysregulation in its expression or function can lead to unrestrained PI3K signaling which is implicated in tumorigenesis. PIK3IP1 interaction with the PI3K pathway can also relate to insulin signaling linking it to disorders such as type 2 diabetes. In cancer PIK3IP1 can alter interactions with oncogenic proteins like PTEN which also influences PI3K pathway activity.
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