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AB185388

Recombinant Human PIK3IP1 protein

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(1 Publication)

Recombinant Human PIK3IP1 protein is a Human Fragment protein, in the 22 to 168 aa range, expressed in Mammalian, with >95%, < 1 EU/µg endotoxin level, suitable for SDS-PAGE, HPLC.

View Alternative Names

HGFL, PIK3IP1, Phosphoinositide-3-kinase-interacting protein 1, PI3K-interacting protein 1, Kringle domain-containing protein HGFL

Key facts

Purity

>95% SDS-PAGE

Endotoxin level

< 1 EU/µg

Expression system

Mammalian

Tags

His tag C-Terminus

Applications

HPLC, SDS-PAGE

applications

Biologically active

No

Accession

Q96FE7

Animal free

No

Carrier free

No

Species

Human

Reconstitution

Reconstitute in 3X PBS

Storage buffer

pH: 8 Constituents: 0.79% Tris HCl, 0.31% Glutathione

storage-buffer

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Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Reactivity", "Dilution Info", "Notes"] }, "values": { "SDS-PAGE": { "reactivity":"TESTED_AND_REACTS", "dilution-info":"", "notes":"<p></p>" }, "HPLC": { "reactivity":"TESTED_AND_REACTS", "dilution-info":"", "notes":"<p></p>" } } }
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Product details

Dissolve the lyophilized protein in 3X PBS. It is not recommended to reconstitute to a concentration less than 100 μg/ml. Always centrifuge tubes before opening. Do not mix by vortex or pipetting.
Reconstituted protein should be aliquoted and stored at < -20°C.
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Sequence info

[{"sequence":"SGGCFWDNGHLYREDQTSPAPGLRCLNWLDAQSGLASAPVSGAGNHSYCRNPDEDPRGPWCYVSGEAGVPEKRPCEDLRCPETTSQALPAFTTEIQEASEGPGADEVQVFAPANALPARSEAAAVQPVIGISQRVRMNSKEKKDLGTVDHHHHHH","proteinLength":"Fragment","predictedMolecularWeight":"17 kDa","actualMolecularWeight":null,"aminoAcidEnd":168,"aminoAcidStart":22,"nature":"Recombinant","expressionSystem":"Mammalian","accessionNumber":"Q96FE7","tags":[{"tag":"His","terminus":"C-Terminus"}]}]
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Properties and storage information

Shipped at conditions
Blue Ice
Appropriate short-term storage duration
A few weeks
Appropriate short-term storage conditions
-20°C
Appropriate long-term storage conditions
-20°C
False
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Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

PIK3IP1 also known as phosphoinositide-3-kinase-interacting protein 1 plays an important role in regulating PI3K (phosphoinositide 3-kinase) activity. It is an inhibitory molecule that modulates PI3K signaling. This protein has a molecular mass of approximately 24 kDa. PIK3IP1 expression occurs mainly in the liver and other tissues such as the spleen and lung.
Biological function summary

PIK3IP1 serves as a negative regulator in PI3K signaling impacting cell growth and survival. It is not part of a larger complex but interacts directly with components of the PI3K pathway. Its regulation impacts cell processes by modulating one of the main pathways controlling cellular proliferation and survival.

Pathways

PIK3IP1 plays an inhibitory role in the PI3K/AKT/mTOR pathway which is essential in regulating cell proliferation and metabolism. This pathway involves proteins like AKT and mTOR which contribute to cell growth and survival regulation. By inhibiting PI3K PIK3IP1 affects the downstream signaling of AKT and mTOR therefore also impacting other related pathways involved in metabolic processes.

PIK3IP1 has associations with cancer and metabolic disorders. Dysregulation in its expression or function can lead to unrestrained PI3K signaling which is implicated in tumorigenesis. PIK3IP1 interaction with the PI3K pathway can also relate to insulin signaling linking it to disorders such as type 2 diabetes. In cancer PIK3IP1 can alter interactions with oncogenic proteins like PTEN which also influences PI3K pathway activity.
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Specifications

Form

Lyophilized

Additional notes

Determined by SEC-HPLC and reducing SDS-PAGE.

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General info

Function

Negative regulator of hepatic phosphatidylinositol 3-kinase (PI3K) activity.

Post-translational modifications

N- and O-glycosylated. O-glycosylated with core 1 or possibly core 8 glycans. N-glycan heterogeneity at Asn-66: dHex1Hex5HexNAc4 (major) and dHex1Hex6HexNAc5 (minor).

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Product protocols

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Target data

Negative regulator of hepatic phosphatidylinositol 3-kinase (PI3K) activity.
See full target information PIK3IP1
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Publications (1)

Recent publications for all applications. Explore the full list and refine your search

Discover oncology 16:50 PubMed39812903

2025

Therapeutic implications and comprehensive insights into cellular senescence and aging in the tumor microenvironment of sarcoma.

Applications

Unspecified application

Species

Unspecified reactive species

Pengfei Zan,Yi Zhang,Yidong Zhu,Qingjing Chen,Zhengwei Duan,Yonghao Guan,Kaiyuan Liu,Anquan Shang,Zihua Li
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