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AB276589

Recombinant Human PILRA protein (His tag)

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Recombinant Human PILRA protein (His tag) is a Human Fragment protein, in the 1 to 226 aa range, expressed in HEK 293 cells, with >95%, < 1 EU/µg endotoxin level, suitable for SDS-PAGE.

View Alternative Names

Paired immunoglobulin-like type 2 receptor alpha, Cell surface receptor FDF03, Inhibitory receptor PILR-alpha, PILRA

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SDS-PAGE - Recombinant Human PILRA protein (His tag) (AB276589)
  • SDS-PAGE

Supplier Data

SDS-PAGE - Recombinant Human PILRA protein (His tag) (AB276589)

SDS-PAGE analysis of ab276589.

Key facts

Purity

>95% SDS-PAGE

Endotoxin level

< 1 EU/µg

Expression system

HEK 293 cells

Tags

His tag C-Terminus

Applications

SDS-PAGE

applications

Biologically active

No

Accession

Q9UKJ1

Animal free

No

Carrier free

No

Species

Human

Storage buffer

pH: 7.4 Constituents: PBS

storage-buffer

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Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Reactivity", "Dilution Info", "Notes"] }, "values": { "SDS-PAGE": { "reactivity":"TESTED_AND_REACTS", "dilution-info":"", "notes":"<p></p>" } } }
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Sequence info

[{"sequence":"MGRPLLLPLLPLLLPPAFLQPSGSTGSGPSYLYGVTQPKHLSASMGGSVEIPFSFYYPWELATAPDVRISWRRGHFHRQSFYSTRPPSIHKDYVNRLFLNWTEGQKSGFLRISNLQKQDQSVYFCRVELDTRSSGRQQWQSIEGTKLSITQAVTTTTQRPSSMTTTWRLSSTTTTTGLRVTQGKRRSDSWHISLETAVGVAVAVTVLGIMILGLICLLRWRRRKGQ","proteinLength":"Fragment","predictedMolecularWeight":"24.9 kDa","actualMolecularWeight":null,"aminoAcidEnd":226,"aminoAcidStart":1,"nature":"Recombinant","expressionSystem":"HEK 293 cells","accessionNumber":"Q9UKJ1","tags":[{"tag":"His","terminus":"C-Terminus"}]}]
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Properties and storage information

Shipped at conditions
Ambient - Can Ship with Ice
Appropriate short-term storage conditions
-20°C
Appropriate long-term storage conditions
-20°C
Aliquoting information
Upon delivery aliquot
Storage information
Avoid freeze / thaw cycle
False
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Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

PILRA also known as Paired immunoglobulin-like type 2 receptor alpha is a protein with a mass of about 38 kDa. It belongs to the immunoglobulin superfamily and acts as an inhibitory receptor. PILRA is expressed mainly in human tissues such as monocytes macrophages and certain subsets of dendritic cells. It interacts with ligands through its extracellular domain and transmits inhibitory signals via its cytoplasmic tail that contains immunoreceptor tyrosine-based inhibitory motifs (ITIMs).
Biological function summary

PILRA plays a significant role in the immune system regulation by inhibiting cellular activation processes. This regulation occurs through its participation in receptor-ligand interactions that modulate the immune response. It is not part of a complex but its pair PILRB acts as an activating receptor providing a balanced modulation of immune signaling. The balance between PILRA and PILRB affects how immune cells respond to various signals.

Pathways

PILRA is centrally involved in immune response pathways especially those controlling immune cell signaling. It interacts with proteins involved in immune system pathways such as LILRB1 which also mediates inhibitory signaling. PILRA functions in signaling pathways to regulate the activation and inhibition of immune responses maintaining immune system homeostasis.

PILRA associates with alterations in immune response mechanisms that can lead to autoimmune diseases and infections. Research links PILRA to diseases such as multiple sclerosis and certain viral infections. In these conditions PILRA's role in immune signaling modulation becomes important as it coordinates with proteins like PILRB to affect the immune system's response to different pathological conditions.
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Specifications

Form

Lyophilized

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General info

Function

Paired receptors consist of highly related activating and inhibitory receptors and are widely involved in the regulation of the immune system. PILRA is thought to act as a cellular signaling inhibitory receptor by recruiting cytoplasmic phosphatases like PTPN6/SHP-1 and PTPN11/SHP-2 via their SH2 domains that block signal transduction through dephosphorylation of signaling molecules. Receptor for PIANP.. (Microbial infection) Acts as an entry co-receptor for herpes simplex virus 1.

Post-translational modifications

According to PubMed:10660620, N- and O-glycosylated. According to PubMed:10903717, only N-glycosylated.. Phosphorylated on tyrosine residues.

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Product protocols

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Target data

Paired receptors consist of highly related activating and inhibitory receptors and are widely involved in the regulation of the immune system. PILRA is thought to act as a cellular signaling inhibitory receptor by recruiting cytoplasmic phosphatases like PTPN6/SHP-1 and PTPN11/SHP-2 via their SH2 domains that block signal transduction through dephosphorylation of signaling molecules. Receptor for PIANP.. (Microbial infection) Acts as an entry co-receptor for herpes simplex virus 1.
See full target information PILRA
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