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AB162302

Recombinant Human PILRB protein (GST tag N-Terminus)

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Recombinant Human PILRB protein (GST tag N-Terminus) is a Human Full Length protein, in the 1 to 227 aa range, expressed in Wheat germ, suitable for ELISA, WB.

View Alternative Names

FDFACT, PP1551, PILRB, Paired immunoglobulin-like type 2 receptor beta, Activating receptor PILR-beta, Cell surface receptor FDFACT

1 Images
SDS-PAGE - Recombinant Human PILRB protein (AB162302)
  • SDS-PAGE

Supplier Data

SDS-PAGE - Recombinant Human PILRB protein (AB162302)

ab162302 on a 12.5% SDS-PAGE stained with Coomassie Blue.

Key facts

Expression system

Wheat germ

Tags

GST tag N-Terminus

Applications

ELISA, WB

applications

Biologically active

No

Accession

Q9UKJ0

Animal free

No

Carrier free

No

Species

Human

Storage buffer

pH: 8 Constituents: 0.79% Tris HCl, 0.31% Glutathione

storage-buffer

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Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Reactivity", "Dilution Info", "Notes"] }, "values": { "ELISA": { "reactivity":"TESTED_AND_REACTS", "dilution-info":"", "notes":"<p></p>" }, "WB": { "reactivity":"TESTED_AND_REACTS", "dilution-info":"", "notes":"<p></p>" } } }
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Sequence info

[{"sequence":"MGRPLLLPLLLLLQPPAFLQPGGSTGSGPSYLYGVTQPKHLSASMGGSVEIPFSFYYPWELAIVPNVRISWRRGHFHGQSFYSTRPPSIHKDYVNRLFLNWTEGQESGFLRISNLRKEDQSVYFCRVELDTRRSGRQQLQSIKGTKLTITQAVTTTTTWRPSSTTTIAGLRVTESKGHSESWHLSLDTAIRVALAVAVLKTVILGLLCLLLLWWRRRKGSRAPSSDF","proteinLength":"Full Length","predictedMolecularWeight":null,"actualMolecularWeight":null,"aminoAcidEnd":227,"aminoAcidStart":1,"nature":"Recombinant","expressionSystem":"Wheat germ","accessionNumber":"Q9UKJ0","tags":[{"tag":"GST","terminus":"N-Terminus"}]}]
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Properties and storage information

Shipped at conditions
Dry Ice
Appropriate short-term storage conditions
-80°C
Appropriate long-term storage conditions
-80°C
Aliquoting information
Upon delivery aliquot
Storage information
Avoid freeze / thaw cycle
False
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Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

PILRB also known as paired immunoglobulin-like type 2 receptor beta is a transmembrane protein involved in immune signaling. It has a molecular weight of approximately 33 kDa. You can find its expression mainly on the surface of various immune cells including myeloid and natural killer (NK) cells. PILRB contains an immunoreceptor tyrosine-based activation motif (ITAM) within its cytoplasmic domain which plays a role in transmitting activation signals inside the cells.
Biological function summary

In immune response and signaling PILRB functions by interacting with other proteins on immune cells to modulate their activity. It works as part of a receptor complex with paired immunoglobulin-like type 2 receptor alpha (PILRA) which plays a complementary inhibitory role. This balance between PILRB and PILRA on cell surfaces helps regulate immune cell activation and maintain homeostasis within the immune system.

Pathways

PILRB has a role in pathways related to immune regulation and innate immunity. It participates in signaling pathways that involve its counterpart PILRA. An important pathway where PILRB is active includes the immune checkpoint pathway where it is related to NK cell activation and cytokine production. PILRB modulates the activity of other signaling molecules and receptors playing a part in pathways shared with proteins like SHP-1 and SHP-2.

Studies have shown PILRB's relevance in autoimmune diseases and cancer. Alterations in PILRB signaling can influence the progression of autoimmune conditions by affecting immune cell activation and self-tolerance. It is also involved in tumor immune evasion mechanisms. In these contexts PILRB relates to proteins like PD-1 and CTLA-4 which are also critical in immune checkpoint pathways and associated with both autoimmune diseases and cancer immunotherapy targets.
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Specifications

Form

Liquid

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General info

Function

Paired receptors consist of highly related activating and inhibitory receptors and are widely involved in the regulation of the immune system. PILRB is thought to act as a cellular signaling activating receptor that associates with ITAM-bearing adapter molecules on the cell surface.

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Product protocols

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Target data

Paired receptors consist of highly related activating and inhibitory receptors and are widely involved in the regulation of the immune system. PILRB is thought to act as a cellular signaling activating receptor that associates with ITAM-bearing adapter molecules on the cell surface.
See full target information PILRB
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