Recombinant Human PILRB protein is a Human Full Length protein, in the 1 to 227 aa range, expressed in Wheat germ and suitable for ELISA, WB.
Images
Key facts
- Expression system
- Wheat germ
- Tags
- GST tag N-Terminus
- Applications
- ELISA, WB
- Biologically active
- No
Amino acid sequence
M G R P L L L P L L L L L Q P P A F L Q P G G S T G S G P S Y L Y G V T Q P K H L S A S M G G S V E I P F S F Y Y P W E L A I V P N V R I S W R R G H F H G Q S F Y S T R P P S I H K D Y V N R L F L N W T E G Q E S G F L R I S N L R K E D Q S V Y F C R V E L D T R R S G R Q Q L Q S I K G T K L T I T Q A V T T T T T W R P S S T T T I A G L R V T E S K G H S E S W H L S L D T A I R V A L A V A V L K T V I L G L L C L L L L W W R R R K G S R A P S S D F
Reactivity data
| Application | Reactivity | Dilution info | Notes |
|---|---|---|---|
Application ELISA | Reactivity Reacts | Dilution info - | Notes - |
Application WB | Reactivity Reacts | Dilution info - | Notes - |
Target data
Function
Paired receptors consist of highly related activating and inhibitory receptors and are widely involved in the regulation of the immune system. PILRB is thought to act as a cellular signaling activating receptor that associates with ITAM-bearing adapter molecules on the cell surface.
Alternative names
FDFACT, PP1551, PILRB, Paired immunoglobulin-like type 2 receptor beta, Activating receptor PILR-beta, Cell surface receptor FDFACT
Recommended products
Recombinant Human PILRB protein is a Human Full Length protein, in the 1 to 227 aa range, expressed in Wheat germ and suitable for ELISA, WB.
Key facts
- Expression system
- Wheat germ
- Tags
- GST tag N-Terminus
- Applications
- ELISA, WB
- Biologically active
- No
- Accession
- Q9UKJ0-1
- Animal free
- No
- Species
- Human
- Concentration
- Storage buffer
pH: 8
Constituents: 0.79% Tris HCl, 0.31% Glutathione
Sequence info
Amino acid sequence
- M G R P L L L P L L L L L Q P P A F L Q P G G S T G S G P S Y L Y G V T Q P K H L S A S M G G S V E I P F S F Y Y P W E L A I V P N V R I S W R R G H F H G Q S F Y S T R P P S I H K D Y V N R L F L N W T E G Q E S G F L R I S N L R K E D Q S V Y F C R V E L D T R R S G R Q Q L Q S I K G T K L T I T Q A V T T T T T W R P S S T T T I A G L R V T E S K G H S E S W H L S L D T A I R V A L A V A V L K T V I L G L L C L L L L W W R R R K G S R A P S S D F
- Accession
- Q9UKJ0
- Protein length
- Full Length
- Amino acids
- 1 to 227
- Nature
- Recombinant
- Tags
- GST tag N-Terminus
Specifications
- Form
- Liquid
General info
- Function
Paired receptors consist of highly related activating and inhibitory receptors and are widely involved in the regulation of the immune system. PILRB is thought to act as a cellular signaling activating receptor that associates with ITAM-bearing adapter molecules on the cell surface.
Storage
- Shipped at conditions
- Dry Ice
- Appropriate short-term storage conditions
- -80°C
- Appropriate long-term storage conditions
- -80°C
- Aliquoting information
- Upon delivery aliquot
- Storage information
- Avoid freeze / thaw cycle
Supplementary info
- This supplementary information is collated from multiple sources and compiled automatically.
- Activity summary
PILRB also known as paired immunoglobulin-like type 2 receptor beta is a transmembrane protein involved in immune signaling. It has a molecular weight of approximately 33 kDa. You can find its expression mainly on the surface of various immune cells including myeloid and natural killer (NK) cells. PILRB contains an immunoreceptor tyrosine-based activation motif (ITAM) within its cytoplasmic domain which plays a role in transmitting activation signals inside the cells.
- Biological function summary
In immune response and signaling PILRB functions by interacting with other proteins on immune cells to modulate their activity. It works as part of a receptor complex with paired immunoglobulin-like type 2 receptor alpha (PILRA) which plays a complementary inhibitory role. This balance between PILRB and PILRA on cell surfaces helps regulate immune cell activation and maintain homeostasis within the immune system.
- Pathways
PILRB has a role in pathways related to immune regulation and innate immunity. It participates in signaling pathways that involve its counterpart PILRA. An important pathway where PILRB is active includes the immune checkpoint pathway where it is related to NK cell activation and cytokine production. PILRB modulates the activity of other signaling molecules and receptors playing a part in pathways shared with proteins like SHP-1 and SHP-2.
- Associated diseases and disorders
Studies have shown PILRB's relevance in autoimmune diseases and cancer. Alterations in PILRB signaling can influence the progression of autoimmune conditions by affecting immune cell activation and self-tolerance. It is also involved in tumor immune evasion mechanisms. In these contexts PILRB relates to proteins like PD-1 and CTLA-4 which are also critical in immune checkpoint pathways and associated with both autoimmune diseases and cancer immunotherapy targets.
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1 product image
SDS-PAGE - Recombinant Human PILRB protein (ab162302)
ab162302 on a 12.5% SDS-PAGE stained with Coomassie Blue.
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