Recombinant Human PINX1/LPTS protein (His tag N-Terminus)
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Recombinant Human PINX1/LPTS protein (His tag N-Terminus) is a Human Full Length protein, expressed in Escherichia coli, with >95%, suitable for SDS-PAGE.
View Alternative Names
LPTL, LPTS, PINX1, PIN2/TERF1-interacting telomerase inhibitor 1, Liver-related putative tumor suppressor, Pin2-interacting protein X1, Protein 67-11-3, TRF1-interacting protein 1
- SDS-PAGE
Unknown
SDS-PAGE - Recombinant Human PINX1/LPTS protein (His tag N-Terminus) (AB85338)
15% SDS-PAGE showing ab85338 at approximately 39.1kDa (3μg).
Complementary Products
Reactivity data
Product details
Sequence info
Properties and storage information
Shipped at conditions
Appropriate short-term storage conditions
Appropriate long-term storage conditions
Aliquoting information
Storage information
Supplementary information
This supplementary information is collated from multiple sources and compiled automatically.
Biological function summary
PINX1/LPTS serves as a regulatory factor that ensures genomic integrity by directly inhibiting telomerase. It is not confirmed part of a specific large protein complex but its interaction with telomerase suggests it functions closely within a group of regulatory proteins. Its activity contributes to cell cycle regulation particularly influencing cellular senescence and apoptosis by controlling telomere length.
Pathways
The role of PINX1/LPTS in telomerase inhibition places it in the context of telomeric maintenance and regulation pathways. It closely associates with proteins such as hTERT the catalytic subunit of telomerase and influences the shelterin complex pathways which protect telomeres from being recognized as DNA damage. This positioning emphasizes its involvement in regulating cell aging and proliferation pathways.
Specifications
Form
Liquid
Additional notes
ab85338 is purified using conventional chromatography techniques.Endotoxin level: < 1.0 EU per 1 μg of protein (determined by LAL method ).
General info
Function
Microtubule-binding protein essential for faithful chromosome segregation. Mediates TRF1 and TERT accumulation in nucleolus and enhances TRF1 binding to telomeres. Inhibits telomerase activity. May inhibit cell proliferation and act as tumor suppressor.
Sequence similarities
Belongs to the PINX1 family.
Post-translational modifications
Cleaved by enterovirus protease 3C to promote apoptosis.
Subcellular localisation
Nucleus
Target data
Product promise
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