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AB127327

Recombinant Human PITPnm 3 protein (His-DHFR tag N-Terminus)

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Recombinant Human PITPnm 3 protein (His-DHFR tag N-Terminus) is a Human Fragment protein, in the 237 to 478 aa range, expressed in Escherichia coli, with >85%, suitable for SDS-PAGE.

View Alternative Names

NIR1, PITPNM3, Membrane-associated phosphatidylinositol transfer protein 3, Pyk2 N-terminal domain-interacting receptor 1, PITPnm 3, NIR-1

Key facts

Purity

>85% SDS-PAGE

Expression system

Escherichia coli

Tags

His-DHFR tag N-Terminus

Applications

SDS-PAGE

applications

Biologically active

No

Accession

Q9BZ71

Animal free

No

Carrier free

No

Species

Human

Reconstitution

Reconstitute in water

Storage buffer

Constituents: 0.58% Sodium chloride, 0.32% Tris HCl

storage-buffer

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Complementary Products

Primary Antibodies

AB251739

Anti-PITPnm 3 antibody

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-PITPnm 3 antibody (AB251739)

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Primary Antibodies

AB318973

Anti-COL8A1 antibody [EPR28738-178] - BSA and Azide free

BOND RX™ Validated|Recombinant|RabMAb

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-COL8A1 antibody [EPR28738-178] - BSA and Azide free (AB318973)

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Proteins & Peptides

AB171594

Recombinant Human ISOC2 protein (denatured) (His tag N-Terminus)

SDS-PAGE - Recombinant Human ISOC2 protein (denatured) (His tag N-Terminus) (AB171594)

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Proteins & Peptides

AB131700

Recombinant Human Dkk3 protein (denatured) (His tag N-Terminus)

SDS-PAGE - Recombinant Human Dkk3 protein (denatured) (His tag N-Terminus) (AB131700)

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  • 0
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Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Reactivity", "Dilution Info", "Notes"] }, "values": { "SDS-PAGE": { "reactivity":"TESTED_AND_REACTS", "dilution-info":"", "notes":"<p></p>" } } }
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Sequence info

[{"sequence":"","proteinLength":"Fragment","predictedMolecularWeight":"26 kDa","actualMolecularWeight":null,"aminoAcidEnd":478,"aminoAcidStart":237,"nature":"Recombinant","expressionSystem":null,"accessionNumber":"Q9BZ71","tags":[{"tag":"His-DHFR","terminus":"N-Terminus"}]}]
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Properties and storage information

Shipped at conditions
Blue Ice
Appropriate short-term storage conditions
-20°C
Appropriate long-term storage conditions
-20°C
False
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Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

PITPnm 3 also known as phosphatidylinositol transfer protein cytoplasmic 1 has a mass of around 40 kDa. This protein functions by transferring phosphatidylinositol and phosphatidylcholine between membranes playing a role in lipid metabolism. It is expressed in various tissues including the brain liver and placenta. The presence of PITPnm 3 is important in maintaining proper membrane lipid composition and signaling pathways within these cells.
Biological function summary

The function of PITPnm 3 extends to regulating intracellular signaling by managing lipid interfaces. It supports the formation and dynamics of membrane structures which are necessary for vesicular trafficking and membrane curvature. The protein operates as part of the phosphoinositide signaling complex aiding in membrane identity and compartmentalization. Its role is essential for normal cellular communication and organelle function.

Pathways

The involvement of PITPnm 3 extends to the phosphoinositide cycle and the inositol lipid signaling pathway. This protein interacts with phospholipase C and Akt contributing to the production of secondary messengers which mediate various cellular responses including proliferation and survival. Such interactions link PITPnm 3 to signaling cascades that are important for maintaining cellular homeostasis and response to environmental stimuli.

The dysregulation of PITPnm 3 activity has been associated with neurodegenerative diseases like Alzheimer's disease and metabolic disorders such as diabetes. Misregulation can affect lipid signaling and membrane trafficking contributing to disease pathogenesis. The relationship between PITPnm 3 and proteins like tau in Alzheimer's or insulin signaling components in diabetes highlights its significant role in disease mechanisms. Understanding these connections aids in developing targeted therapeutic strategies.
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Specifications

Form

Lyophilized

Additional notes

Purified via His tag

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General info

Function

Catalyzes the transfer of phosphatidylinositol and phosphatidylcholine between membranes (in vitro) (By similarity). Binds calcium ions.

Sequence similarities

Belongs to the PtdIns transfer protein family. PI transfer class IIA subfamily.

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Product protocols

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Target data

Catalyzes the transfer of phosphatidylinositol and phosphatidylcholine between membranes (in vitro) (By similarity). Binds calcium ions.
See full target information PITPNM3
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Product promise

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