Recombinant Human PITPNM2 protein

Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

PITPNM2 also known as phosphatidylinositol transfer protein membrane-associated 2 is a protein that plays a significant role in lipid transfer. It weighs approximately 138 kDa and interacts with membranes to facilitate phosphoinositide signaling. PITPNM2 mainly expresses in the brain and other central nervous system regions. Through its phosphatidylinositol-binding activity it regulates the transfer of lipids between membrane compartments ensuring cellular lipid homeostasis.

Biological function summary

This protein participates in complex regulation of intracellular signaling pathways. It is part of specific protein complexes that aid in signal transduction processes essential for normal neuronal function. The presence of PITPNM2 in neuronal tissues suggests its involvement in brain-specific signaling pathways where it may influence synaptic stability and neurotransmitter release.

Pathways

PITPNM2 engages in important signaling pathways including the phosphoinositide signaling pathway. This pathway is essential for membrane trafficking and signal cascade processes. PITPNM2 interacts closely with proteins such as phospholipase C which mediates the hydrolysis of phosphatidylinositol 45-bisphosphate into second messengers. These second messengers further transmit signals that regulate various cellular processes including calcium mobilization and protein kinase C activation.

Dysregulation of PITPNM2 has associations with neurological conditions such as epilepsy and certain neurodegenerative diseases. Altered function of this protein may disrupt phosphoinositide signaling resulting in synaptic dysfunction. PITPNM2's interaction with signaling proteins like phospholipase C could contribute to pathophysiological mechanisms underlying these disorders highlighting the importance of this protein in maintaining neural health.