Recombinant human PKC nu/PRKD3 protein

Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

Protein kinase C nu also known as PRKD3 is an important serine/threonine kinase located in the protein kinase D family. This protein has a molecular mass of approximately 102 kDa. PRKD3 is mainly expressed in human tissues like the brain heart and lungs. It plays a role in cellular processes by phosphorylating various substrates. The protein can localize to different cellular compartments allowing it to conduct multiple signaling roles effectively.

Biological function summary

PRKD3 influences cellular responses to environmental stress and regulates gene expression. It can promote cell proliferation and survival by being part of a complex signaling network. This protein modulates transcription factors and cellular mechanisms to maintain homeostasis under changing conditions. PRKD3 has interactions with other kinases within its family helping to fine-tune signal transduction processes.

Pathways

PKC nu/PRKD3 integrates into the MAPK signaling cascades essential for proliferative and stress-responses. It also interacts within the NF-kB pathway which regulates immune responses and inflammation. These pathways involve various other proteins like ERKs and IκB kinase positioning PRKD3 as a regulatory node in key cellular activities. This interconnection emphasizes the protein's versatile role in cellular adaptation and signaling.

PRKD3 shows associations with cancer and cardiovascular diseases. The protein's influence over cell growth and apoptosis links it to oncogenic processes making it relevant in cancer research. Additionally its role in heart tissue suggests connections with cardiovascular pathologies. PRKD3 associates with proteins like Bcl-2 in cancer and influences pathways related to heart functions highlighting its relevance in these disorders.