Recombinant Human PKIB protein

Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

PKIB or Protein Kinase Inhibitor Beta acts as an inhibitor for protein kinase A (PKA). It belongs to the family of PKI proteins that include PKIA and PKIG. PKIB contributes to the cellular process by binding to PKA and preventing its activity therefore affecting its downstream effects. PKIB has a molecular mass of approximately 9 kDa. It expresses predominantly in tissues such as the prostate and brain reflecting its specific roles in different cellular contexts.

Biological function summary

The inhibition of PKA by PKIB plays a role in regulating cellular proliferation and apoptosis. PKIB does not form part of a larger complex but functions through direct interactions with its target PKA. PKIB's inhibitory action on PKA can modulate several downstream signalling cascades affecting various cellular outcomes according to the cellular context and signals received.

Pathways

PKIB impacts key signalling networks such as the cAMP-dependent PKA pathway and the MAPK/ERK pathway. PKIB's interaction with PKA affects the transduction of signals initiated by cyclic AMP which influences cellular processes diversity. PKIB assists in the modulation of MAPK/ERK pathway working in concert with other proteins like AKAPs that organize PKA signaling compartments allowing for refined control over cellular responses to signaling.

PKIB emerges as relevant in prostate cancer and certain neurological disorders. The association of PKIB with prostate cancer arises from the deregulation of PKA activity affecting cell proliferation and survival. Through interactions with other signaling proteins like CREB dysregulated PKIB expression might contribute to the pathology of cancer. Furthermore altered PKIB expression patterns have also been observed in neurological disorders where imbalanced kinase activities disrupt normal brain function.