Recombinant Human Plasma Kallikrein 1B Protein (Active)
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Recombinant Human Plasma Kallikrein 1B Protein (Active) is a Human Full Length protein, in the 20 to 638 aa range, expressed in HEK 293 cells, with >95%, <0.005 EU/µg endotoxin level, suitable for SDS-PAGE, Mass Spec, HPLC, FuncS.
View Alternative Names
KLK3, KLKB1, Plasma kallikrein, Fletcher factor, Kininogenin, Plasma prekallikrein, PKK
- FuncS
Supplier Data
Functional Studies - Recombinant Human Plasma Kallikrein 1B Protein (Active) (AB307350)
Fully active determined by its ability to cleave fluorogenic peptide substrate Pro-Phe-Arg-7-amido-4-methylcoumarin (PFR-AMC). The specific activity is ≥ 400 pmol/min/ug.
- Mass Spec
Supplier Data
Mass Spectrometry - Recombinant Human Plasma Kallikrein 1B Protein (Active) (AB307350)
Mass determination by ESI-TOF. Predicted MW is 69261.11 Da (+/-10 Da by ESI-TOF). Observed MW is 69266.01 Da.
- SDS-PAGE
Supplier Data
SDS-PAGE - Recombinant Human Plasma Kallikrein 1B Protein (Active) (AB307350)
SDS-PAGE analysis of ab307350
- HPLC
Supplier Data
HPLC - Recombinant Human Plasma Kallikrein 1B Protein (Active) (AB307350)
HPLC analysis of ab307350
Complementary Products
Reagents, Controls & Accessories
AB313995
Prestained Protein Ladder - Mid-range molecular weight (15 - 170 kDa)
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Primary Antibodies
AB315396
Anti-Plasma Kallikrein 1B antibody [RM2034]
BOND RX™ Validated|20ul selling size|RabMAb|Recombinant
![Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-Plasma Kallikrein 1B antibody [RM2034] (AB315396)](https://content.abcam.com/products/images/plasma-kallikrein-1b-antibody-rm2034-ab315396--immunohistochemistry-formalin-pfa-fixed-paraffin-embedded-sections-img425495.jpg)
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Reactivity data
Sequence info
Properties and storage information
Shipped at conditions
Appropriate short-term storage conditions
Appropriate long-term storage conditions
Supplementary information
This supplementary information is collated from multiple sources and compiled automatically.
Biological function summary
Plasma Kallikrein 1B plays significant roles in the kinin-kallikrein system. Within this system it cleaves high-molecular-weight kininogen to release bradykinin a potent vasodilator. This enzyme is not part of a larger protein complex but operates independently to modulate various physiological responses. Plasma kallikrein's activity influences processes like pain vasodilation and inflammation making it important in homeostasis and acute-phase responses.
Pathways
Plasma Kallikrein 1B participates actively in the kallikrein-kinin and the contact activation pathways. In the kallikrein-kinin system it works alongside high-molecular-weight kininogen and factor XII which plays an important role in the intrinsic pathway of coagulation. Plasma kallikrein's enzymatic activities lead to the production of bradykinin and other peptides impacting blood pressure and inflammatory processes.
Specifications
Form
Lyophilized
Additional notes
SDS-PAGE >= 95%
General info
Function
Participates in the surface-dependent activation of blood coagulation. Activates, in a reciprocal reaction, coagulation factor XII/F12 after binding to negatively charged surfaces. Releases bradykinin from HMW kininogen and may also play a role in the renin-angiotensin system by converting prorenin into renin.
Sequence similarities
Belongs to the peptidase S1 family. Plasma kallikrein subfamily.
Target data
Product promise
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