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AB226422

Recombinant Human Plexin A1 protein (His tag)

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(1 Publication)

Recombinant Human Plexin A1 protein (His tag) is a Human Fragment protein, in the 986 to 1152 aa range, expressed in Escherichia coli, with >90%, suitable for SDS-PAGE.

View Alternative Names

NOV, PLXN1, PLXNA1, Plexin-A1, Semaphorin receptor NOV

1 Images
SDS-PAGE - Recombinant Human Plexin A1 protein (His tag) (AB226422)
  • SDS-PAGE

Supplier Data

SDS-PAGE - Recombinant Human Plexin A1 protein (His tag) (AB226422)

(Tris-Glycine gel) Discontinuous SDS-PAGE (reduced) with 5% enrichment gel and 15% separation gel.

Key facts

Purity

>90% SDS-PAGE

Expression system

Escherichia coli

Tags

His tag N-Terminus

Applications

SDS-PAGE

applications

Biologically active

No

Accession

Q9UIW2

Animal free

No

Carrier free

No

Species

Human

Storage buffer

Constituents: Tris buffer, 50% Glycerol (glycerin, glycerine)

storage-buffer

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Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Reactivity", "Dilution Info", "Notes"] }, "values": { "SDS-PAGE": { "reactivity":"TESTED_AND_REACTS", "dilution-info":"", "notes":"<p></p>" } } }
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Sequence info

[{"sequence":"LNAGSDVAVSVGGRPCSFSWRNSREIRCLTPPGQSPGSAPIIININRAQLTNPEVKYNYTEDPTILRIDPEWSINSGGTLLTVTGTNLATVREPRIRAKYGGIERENGCLVYNDTTMVCRAPSVANPVRSPPELGERPDELGFVMDNVRSLLVLNSTSFLYYPDPVL","proteinLength":"Fragment","predictedMolecularWeight":"22.3 kDa","actualMolecularWeight":null,"aminoAcidEnd":1152,"aminoAcidStart":986,"nature":"Recombinant","expressionSystem":"Escherichia coli","accessionNumber":"Q9UIW2","tags":[{"tag":"His","terminus":"N-Terminus"}]}]
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Properties and storage information

Shipped at conditions
Blue Ice
Appropriate short-term storage conditions
-20°C
Appropriate long-term storage conditions
-20°C
Aliquoting information
Upon delivery aliquot
Storage information
Avoid freeze / thaw cycle
False
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Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

Plexin A1 also known as PLXNA1 is a transmembrane protein that acts as a receptor for semaphorin proteins. It is involved in signaling pathways that guide cell migration and axonal growth. This protein has a molecular mass of around 220 kDa. Plexin A1 is expressed in several tissues including the nervous system where it plays a significant role in neural development. The expression levels can vary depending on the tissue type indicating its diverse functions across different biological contexts.
Biological function summary

Plexin A1 functions in neural patterning and the immune response. It is a part of semaphorin signaling complexes that include neuropilins and other plexins. These complexes are critical in translating extracellular cues into intracellular responses impacting cellular dynamics such as motility and adhesion. Plexin A1 also interacts with various intracellular signaling molecules influencing actin cytoskeleton reorganization which is essential for proper neural development.

Pathways

Plexin A1 participates in semaphorin signaling and cytoskeletal dynamics pathways. It interacts with Sema3A and Sema4D proteins which are key signaling semaphorins. These interactions regulate cellular movement by influencing the activity of downstream effectors like Rho and Rac GTPases. The involvement of Plexin A1 in these pathways is important for processes like axon guidance and neuronal connectivity.

Plexin A1 has association with cancer progression and neurodevelopmental disorders. Altered expression levels of Plexin A1 can lead to dysfunction in semaphorin-mediated signaling contributing to conditions such as autism spectrum disorders and tumor metastasis. The protein interacts with Met a receptor tyrosine kinase known to be involved in cancer linking Plexin A1 with oncogenic pathways and providing insights into its role in pathological conditions.
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Specifications

Form

Liquid

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General info

Function

Coreceptor for SEMA3A, SEMA3C, SEMA3F and SEMA6D. Necessary for signaling by class 3 semaphorins and subsequent remodeling of the cytoskeleton. Plays a role in axon guidance, invasive growth and cell migration. Class 3 semaphorins bind to a complex composed of a neuropilin and a plexin. The plexin modulates the affinity of the complex for specific semaphorins, and its cytoplasmic domain is required for the activation of down-stream signaling events in the cytoplasm. Acts as coreceptor of TREM2 for SEMA6D in dendritic cells and is involved in the generation of immune responses and skeletal homeostasis.

Sequence similarities

Belongs to the plexin family.

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Product protocols

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Target data

Coreceptor for SEMA3A, SEMA3C, SEMA3F and SEMA6D. Necessary for signaling by class 3 semaphorins and subsequent remodeling of the cytoskeleton. Plays a role in axon guidance, invasive growth and cell migration. Class 3 semaphorins bind to a complex composed of a neuropilin and a plexin. The plexin modulates the affinity of the complex for specific semaphorins, and its cytoplasmic domain is required for the activation of down-stream signaling events in the cytoplasm. Acts as coreceptor of TREM2 for SEMA6D in dendritic cells and is involved in the generation of immune responses and skeletal homeostasis.
See full target information PLXNA1
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Publications (1)

Recent publications for all applications. Explore the full list and refine your search

International journal of molecular sciences 22: PubMed33809984

2021

Cleavage of the Perlecan-Semaphorin 3A-Plexin A1-Neuropilin-1 (PSPN) Complex by Matrix Metalloproteinase 7/Matrilysin Triggers Prostate Cancer Cell Dyscohesion and Migration.

Applications

Unspecified application

Species

Unspecified reactive species

Tristen V Tellman,Lissette A Cruz,Brian J Grindel,Mary C Farach-Carson
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