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AB276561

Recombinant Human PNLIPRP1 protein (His tag)

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Recombinant Human PNLIPRP1 protein (His tag) is a Human Full Length protein, in the 1 to 467 aa range, expressed in HEK 293 cells, with >90%, < 1 EU/µg endotoxin level, suitable for SDS-PAGE.

View Alternative Names

PLRP1, PNLIPRP1, Inactive pancreatic lipase-related protein 1, PL-RP1

1 Images
SDS-PAGE - Recombinant Human PNLIPRP1 protein (His tag) (AB276561)
  • SDS-PAGE

Supplier Data

SDS-PAGE - Recombinant Human PNLIPRP1 protein (His tag) (AB276561)

SDS-PAGE analysis of ab276561

Key facts

Purity

>90% SDS-PAGE

Endotoxin level

< 1 EU/µg

Expression system

HEK 293 cells

Tags

His tag C-Terminus

Applications

SDS-PAGE

applications

Biologically active

No

Accession

P54315

Animal free

No

Carrier free

No

Species

Human

Storage buffer

pH: 7.4 Constituents: 100% PBS

storage-buffer

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Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Reactivity", "Dilution Info", "Notes"] }, "values": { "SDS-PAGE": { "reactivity":"TESTED_AND_REACTS", "dilution-info":"", "notes":"<p></p>" } } }
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Sequence info

[{"sequence":"MLIFWTITLFLLGAAKGKEVCYEDLGCFSDTEPWGGTAIRPLKILPWSPEKIGTRFLLYTNENPNNFQILLLSDPSTIEASNFQMDRKTRFIIHGFIDKGDESWVTDMCKKLFEVEEVNCICVDWKKGSQATYTQAANNVRVVGAQVAQMLDILLTEYSYPPSKVHLIGHSLGAHVAGEAGSKTPGLSRITGLDPVEASFESTPEEVRLDPSDADFVDVIHTDAAPLIPFLGFGTNQQMGHLDFFPNGGESMPGCKKNALSQIVDLDGIWAGTRDFVACNHLRSYKYYLESILNPDGFAAYPCTSYKSFESDKCFPCPDQGCPQMGHYADKFAGRTSEEQQKFFLNTGEASNFARWRYGVSITLSGRTATGQIKVALFGNKGNTHQYSIFRGILKPGSTHSYEFDAKLDVGTIEKVKFLWNNNVINPTLPKVGATKITVQKGEEKTVYNFCSEDTVREDTLLTLTPC","proteinLength":"Full Length","predictedMolecularWeight":"51.4 kDa","actualMolecularWeight":null,"aminoAcidEnd":467,"aminoAcidStart":1,"nature":"Recombinant","expressionSystem":"HEK 293 cells","accessionNumber":"P54315","tags":[{"tag":"His","terminus":"C-Terminus"}]}]
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Properties and storage information

Shipped at conditions
Ambient - Can Ship with Ice
Appropriate short-term storage conditions
-20°C
Appropriate long-term storage conditions
-20°C
Aliquoting information
Upon delivery aliquot
Storage information
Avoid freeze / thaw cycle
False
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Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

PNLIPRP1 also known as pancreatic lipase-related protein 1 is a member of the pancreatic lipase gene family. This protein has a molecular weight of approximately 54 kDa. PNLIPRP1 expresses mainly in the pancreas where it participates in lipid metabolism by modulating the hydrolysis of dietary triglycerides into free fatty acids. Although not as catalytic as its close relative pancreatic lipase PNLIPRP1 interacts with lipid substrates but behaves differently than digestive enzymes.
Biological function summary

PNLIPRP1 plays a role in the modulation of lipid digestion. It acts more like a lipid-binding protein rather than a typical enzyme potentially regulating the access of pancreatic lipase to lipid substrates. PNLIPRP1 functions outside of large enzyme complexes working independently in the aqueous environment of the intestinal lumen where lipid digestion occurs. Its adaptation to this environment reflects its specialized function in lipid metabolism.

Pathways

PNLIPRP1 participates in the lipid digestion mobilization and transport pathway. This pathway includes actions in the intestines and impacts the bioavailability of dietary lipids. PNLIPRP1 indirectly affects the pathway involving pancreatic lipase (P) which remains the principal enzyme in triglyceride hydrolysis. The interplay between these proteins controls the efficiency of lipid digestion and absorption influencing overall energy homeostasis.

PNLIPRP1 may play a role in metabolic disorders such as obesity. Alterations in lipid metabolism can relate to obesity with PNLIPRP1 modulating dietary fat processing possibly influencing fat storage and utilization. Studies also explore its potential connections to pancreatitis with PNLIPRP1 expression changes observed in cases of pancreatic inflammation. The protein shares associations with pancreatic lipase (L) in these conditions with aberrant expression patterns possibly reflecting clinical symptoms or disease progression.
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Specifications

Form

Lyophilized

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General info

Function

May function as inhibitor of dietary triglyceride digestion. Lacks detectable lipase activity towards triglycerides, diglycerides, phosphatidylcholine, galactolipids or cholesterol esters (in vitro) (By similarity).

Sequence similarities

Belongs to the AB hydrolase superfamily. Lipase family.

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Product protocols

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Target data

May function as inhibitor of dietary triglyceride digestion. Lacks detectable lipase activity towards triglycerides, diglycerides, phosphatidylcholine, galactolipids or cholesterol esters (in vitro) (By similarity).
See full target information PNLIPRP1
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