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AB236342

Recombinant Human PNMA1 protein (Tagged)

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Recombinant Human PNMA1 protein (Tagged) is a Human Full Length protein, in the 1 to 353 aa range, expressed in Escherichia coli, with >85%, suitable for SDS-PAGE.

View Alternative Names

MA1, PNMA1, Paraneoplastic antigen Ma1, 37 kDa neuronal protein, Neuron- and testis-specific protein 1

1 Images
SDS-PAGE - Recombinant Human PNMA1 protein (Tagged) (AB236342)
  • SDS-PAGE

Supplier Data

SDS-PAGE - Recombinant Human PNMA1 protein (Tagged) (AB236342)

(Tris-Glycine gel) Discontinuous SDS-PAGE (reduced) with 5% enrichment gel and 15% separation gel analysis of ab236342.

Key facts

Purity

>85% SDS-PAGE

Expression system

Escherichia coli

Tags

His tag N-Terminus

Applications

SDS-PAGE

applications

Biologically active

No

Accession

Q8ND90

Animal free

No

Carrier free

No

Species

Human

Storage buffer

pH: 7.2 - 7.4 Constituents: Tris buffer, 50% Glycerol (glycerin, glycerine)

storage-buffer

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Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Reactivity", "Dilution Info", "Notes"] }, "values": { "SDS-PAGE": { "reactivity":"TESTED_AND_REACTS", "dilution-info":"", "notes":"<p></p>" } } }
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Sequence info

[{"sequence":"MAMTLLEDWCRGMDVNSQRALLVWGIPVNCDEAEIEETLQAAMPQVSYRMLGRMFWREENAKAALLELTGAVDYAAIPREMPGKGGVWKVLFKPPTSDAEFLERLHLFLAREGWTVQDVARVLGFQNPTPTPGPEMPAEMLNYILDNVIQPLVESIWYKRLTLFSGRDIPGPGEETFDPWLEHTNEVLEEWQVSDVEKRRRLMESLRGPAADVIRILKSNNPAITTAECLKALEQVFGSVESSRDAQIKFLNTYQNPGEKLSAYVIRLEPLLQKVVEKGAIDKDNVNQARLEQVIAGANHSGAIRRQLWLTGAGEGPAPNLFQLLVQIREEEAKEEEEEAEATLLQLGLEGHF","proteinLength":"Full Length","predictedMolecularWeight":"46.8 kDa","actualMolecularWeight":null,"aminoAcidEnd":353,"aminoAcidStart":1,"nature":"Recombinant","expressionSystem":"Escherichia coli","accessionNumber":"Q8ND90","tags":[{"tag":"His","terminus":"N-Terminus"}]}]
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Properties and storage information

Shipped at conditions
Blue Ice
Appropriate short-term storage conditions
-20°C
Appropriate long-term storage conditions
-20°C
Storage information
Avoid freeze / thaw cycle
False
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Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

PNMA1 known as Paraneoplastic Ma Antigen 1 is a protein involved in immunological processes. It has a molecular mass of approximately 40 kDa. This protein is expressed in various tissues including the brain and testis. It has notable relevance in certain neurological contexts associated with paraneoplastic syndromes. Studies have indicated that PNMA1 might play a role in cellular mechanisms involving immune surveillance or response due to its expression pattern and involvement in related pathways.
Biological function summary

PNMA1 interacts within cellular environments likely contributing to neuronal signaling or maintenance. It is suspected to be a part of a larger protein complex which may facilitate its role in modulating immune responses at the cellular level. As such it plays a role in the fine-tuning of immune system activities particularly in the context of tumors where altered expression patterns have been observed. Its presence in such pathway indicates a possible contribution to cellular defense mechanisms.

Pathways

PNMA1 is tied to the immune and neuronal communication paths within the human body. It integrates into the antigen processing and presentation pathway a critical function for recognizing and responding to tumor antigens. Its interactions with related proteins such as PNMA2 and PNMA3 suggest a broader set of functions in immune system regulation and tumor surveillance revealing the interconnected nature of these pathways in maintaining cellular homeostasis and defense.

PNMA1 has associations with paraneoplastic neurological syndromes and testicular cancer. These associations underline its importance in autoimmune responses elicited against nervous system antigens when expressed aberrantly in tumors. PNMA1 interacts with specific antibodies targeting neuronal tissue in paraneoplastic conditions linking it to disease manifestation. Its connection to PNMA2 and other neural-specific antigens suggests a broader spectrum of involvement in neurological immune disorders emphasizing the need for further investigation into its pathological significance.
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Specifications

Form

Liquid

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General info

Sequence similarities

Belongs to the PNMA family.

Subcellular localisation

Nucleus

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Product protocols

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Target data

See full target information PNMA1
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