Recombinant Human PNRC2 protein (denatured) (His tag N-Terminus)
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Recombinant Human PNRC2 protein (denatured) (His tag N-Terminus) is a Human Full Length protein, in the 1 to 139 aa range, expressed in Escherichia coli, with >90%, suitable for SDS-PAGE.
View Alternative Names
HSPC208, PNRC2, Proline-rich nuclear receptor coactivator 2
- SDS-PAGE
Unknown
SDS-PAGE - Recombinant Human PNRC2 protein (denatured) (His tag N-Terminus) (AB167852)
15% SDS-PAGE analysis of 3µg ab167852.
Reactivity data
Sequence info
Properties and storage information
Shipped at conditions
Appropriate short-term storage duration
Appropriate short-term storage conditions
Appropriate long-term storage conditions
Aliquoting information
Storage information
Supplementary information
This supplementary information is collated from multiple sources and compiled automatically.
Biological function summary
PNRC2 interacts with nuclear receptors and transcriptional machinery to modulate gene expression. It acts as a coactivator meaning it enhances the activity of nuclear receptors though it does not bind to DNA directly. PNRC2 forms part of larger multi-protein complexes working in concert with transcription factors to regulate specific target genes. These interactions influence important biological processes including cell growth and apoptosis.
Pathways
PNRC2 impacts nuclear receptor signaling and gene transcription regulation. This protein involves itself in the steroid hormone receptor pathway and potentially the thyroid hormone receptor pathway. In these pathways PNRC2 interacts with proteins such as the Retinoid X Receptor (RXR) and the Estrogen Receptor (ER). These interactions allow PNRC2 to modulate cellular responses to hormones affecting processes such as cell proliferation and differentiation.
Specifications
Form
Liquid
General info
Function
Involved in nonsense-mediated mRNA decay (NMD) by acting as a bridge between the mRNA decapping complex and the NMD machinery (PubMed : 19150429). May act by targeting the NMD machinery to the P-body and recruiting the decapping machinery to aberrant mRNAs (PubMed : 19150429). Required for UPF1/RENT1 localization to the P-body (PubMed : 19150429). Plays a role in glucocorticoid receptor-mediated mRNA degradation by interacting with the glucocorticoid receptor NR3C1 in a ligand-dependent manner when it is bound to the 5' UTR of target mRNAs and recruiting the RNA helicase UPF1 and the mRNA-decapping enzyme DCP1A, leading to RNA decay (PubMed : 25775514). Also acts as a nuclear receptor coactivator (PubMed : 11574675). May play a role in controlling the energy balance between energy storage and energy expenditure (By similarity).
Sequence similarities
Belongs to the PNRC family. PNRC2 subfamily.
Subcellular localisation
Nucleus
Target data
Complementary Products
Product promise
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