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AB165281

Recombinant Human PODN protein

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Recombinant Human PODN protein is a Human Full Length protein, in the 1 to 661 aa range, expressed in Wheat germ, suitable for ELISA, WB.

View Alternative Names

SLRR5A, UNQ293/PRO332, PODN, Podocan

1 Images
SDS-PAGE - Recombinant Human PODN protein (AB165281)
  • SDS-PAGE

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SDS-PAGE - Recombinant Human PODN protein (AB165281)

ab165281 on a 12.5% SDS-PAGE stained with Coomassie Blue.

Key facts

Expression system

Wheat germ

Tags

GST tag N-Terminus

Applications

WB, ELISA

applications

Biologically active

No

Accession

Q7Z5L7

Animal free

No

Carrier free

No

Species

Human

Storage buffer

pH: 8 Constituents: 0.79% Tris HCl, 0.31% Glutathione

storage-buffer

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Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Reactivity", "Dilution Info", "Notes"] }, "values": { "ELISA": { "reactivity":"TESTED_AND_REACTS", "dilution-info":"", "notes":"<p></p>" }, "WB": { "reactivity":"TESTED_AND_REACTS", "dilution-info":"", "notes":"<p></p>" } } }
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Sequence info

[{"sequence":"MEGARARGAQLRLGERVRPVGRRSAPGRSRFHQPWRPGASDSAPPAGTMAQSRVLLLLLLLPPQLHLGPVLAVRAPGFGRSGGHSLSPEENEFAEEEPVLVLSPEEPGPGPAAVSCPRDCACSQEGVVDCGGIDLREFPGDLPEHTNHLSLQNNQLEKIYPEELSRLHRLETLNLQNNRLTSRGLPEKAFEHLTNLNYLYLANNKLTLAPRFLPNALISVDFAANYLTKIYGLTFGQKPNLRSVYLHNNKLADAGLPDNMFNGSSNVEVLILSSNFLRHVPKHLPPALYKLHLKNNKLEKIPPGAFSELSSLRELYLQNNYLTDEGLDNETFWKLSSLEYLDLSSNNLSRVPAGLPRSLVLLHLEKNAIRSVDANVLTPIRSLEYLLLHSNQLREQGIHPLAFQGLKRLHTVHLYNNALERVPSGLPRRVRTLMILHNQITGIGREDFATTYFLEELNLSYNRITSPQVHRDAFRKLRLLRSLDLSGNRLHTLPPGLPRNVHVLKVKRNELAALARGALAGMAQLRELYLTSNRLRSRALGPRAWVDLAHLQLLDIAGNQLTEIPEGLPESLEYLYLQNNKISAVPANAFDSTPNLKGIFLRFNKLAVGSVVDSAFRRLKHLQVLDIEGNLEFGDISKDRGRLGKEKEEEEEEEEEEEETR","proteinLength":"Full Length","predictedMolecularWeight":null,"actualMolecularWeight":null,"aminoAcidEnd":661,"aminoAcidStart":1,"nature":"Recombinant","expressionSystem":"Wheat germ","accessionNumber":"Q7Z5L7","tags":[{"tag":"GST","terminus":"N-Terminus"}]}]
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Properties and storage information

Shipped at conditions
Dry Ice
Appropriate short-term storage conditions
-80°C
Appropriate long-term storage conditions
-80°C
Aliquoting information
Upon delivery aliquot
Storage information
Avoid freeze / thaw cycle
False
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Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

The PODN which stands for Podocan is a leucine-rich repeat protein with a molecular mass of around 60 kDa. It is primarily expressed in connective tissues including cartilage and dermis and also found in vascular tissues. PODN plays a structural role due to its ability to interact with other extracellular matrix components contributing to the organization and stability of tissues where it is expressed. In some literature it is referred to as PODN hub due to its interaction profile in tissue matrices.
Biological function summary

PODN influences cell behavior and tissue remodeling. It modulates the bioavailability of growth factors and interacts with surface receptors affecting cell adhesion migration and proliferation. PODN forms a complex with other matrix proteins and plays a role in maintaining tissue homeostasis. By doing this it influences wound healing processes and tissue repair mechanisms in the body.

Pathways

PODN is involved in the TGF-beta signaling pathway and the ECM-receptor interaction pathway. It interacts with proteins such as fibronectin and decorin within these pathways affecting the deposition and homeostatic regulation of the extracellular matrix. This positions PODN as an important regulator in coordinating communication between cells and their structural environment impacting cell fate decisions and responses to external stimuli.

PODN shows significant roles in vascular diseases and fibrosis. Changes in PODN expression levels have been observed in conditions like atherosclerosis where it associates with collagen and impacts the integrity of vascular tissue. Additionally PODN interacts with proteins like biglycan in fibrotic tissue transformation where its dysregulation can contribute to excessive connective tissue accumulation. Understanding PODN and its interactions may provide insights into potential therapeutic targets for managing these types of disorders.
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Specifications

Form

Liquid

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General info

Function

Negatively regulates cell proliferation and cell migration.

Sequence similarities

Belongs to the small leucine-rich proteoglycan (SLRP) family. SLRP class V subfamily.

Post-translational modifications

N-glycosylated.

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Product protocols

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Target data

Negatively regulates cell proliferation and cell migration.
See full target information PODN
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