Recombinant Human POLR1C protein is a Human Full Length protein, in the 1 to 346 aa range, expressed in Escherichia coli, with >80% purity and suitable for SDS-PAGE, MS.
>80% SDS-PAGE
Escherichia coli
His tag N-Terminus
SDS-PAGE, MS
No
M G S S H H H H H H S S G L V P R G S H M G S M A A S Q A V E E M R S R V V L G E F G V R N V H T T D F P G N Y S G Y D D A W D Q D R F E K N F R V D V V H M D E N S L E F D M V G I D A A I A N A F R R I L L A E V P T M A V E K V L V Y N N T S I V Q D E I L A H R L G L I P I H A D P R L F E Y R N Q G D E E G T E I D T L Q F R L Q V R C T R N P H A A K D S S D P N E L Y V N H K V Y T R H M T W I P L G N Q A D L F P E G T I R P V H D D I L I A Q L R P G Q E I D L L M H C V K G I G K D H A K F S P V A T A S Y R L L P D I T L L E P V E G E A A E E L S R C F S P G V I E V Q E V Q G K K V A R V A N P R L D T F S R E I F R N E K L K K V V R L A R V R D H Y I F S V E S T G V L P P D V L V S E A I K V L M G K C R R F L D E L D A V Q M D
Application | Reactivity | Dilution info | Notes |
---|---|---|---|
Application SDS-PAGE | Reactivity Reacts | Dilution info - | Notes - |
Application MS | Reactivity Reacts | Dilution info - | Notes - |
DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Common component of RNA polymerases I and III which synthesize ribosomal RNA precursors and short non-coding RNAs including 5S rRNA, snRNAs, tRNAs and miRNAs, respectively. POLR1C/RPAC1 is part of the polymerase core and may function as a clamp element that moves to open and close the cleft.
POLR1E, POLR1C, POLR1E, DNA-directed RNA polymerases I and III subunit RPAC1, DNA-directed RNA polymerase I subunit C, RNA polymerases I and III subunit AC1, AC40, DNA-directed RNA polymerases I and III 40 kDa polypeptide, RPA39, RPC40, RPA40
Recombinant Human POLR1C protein is a Human Full Length protein, in the 1 to 346 aa range, expressed in Escherichia coli, with >80% purity and suitable for SDS-PAGE, MS.
>80% SDS-PAGE
Escherichia coli
His tag N-Terminus
SDS-PAGE, MS
No
No
Human
pH: 8
Constituents: 20% Glycerol (glycerin, glycerine), 0.88% Sodium chloride, 0.32% Tris HCl, 0.02% (R*,R*)-1,4-Dimercaptobutan-2,3-diol
M G S S H H H H H H S S G L V P R G S H M G S M A A S Q A V E E M R S R V V L G E F G V R N V H T T D F P G N Y S G Y D D A W D Q D R F E K N F R V D V V H M D E N S L E F D M V G I D A A I A N A F R R I L L A E V P T M A V E K V L V Y N N T S I V Q D E I L A H R L G L I P I H A D P R L F E Y R N Q G D E E G T E I D T L Q F R L Q V R C T R N P H A A K D S S D P N E L Y V N H K V Y T R H M T W I P L G N Q A D L F P E G T I R P V H D D I L I A Q L R P G Q E I D L L M H C V K G I G K D H A K F S P V A T A S Y R L L P D I T L L E P V E G E A A E E L S R C F S P G V I E V Q E V Q G K K V A R V A N P R L D T F S R E I F R N E K L K K V V R L A R V R D H Y I F S V E S T G V L P P D V L V S E A I K V L M G K C R R F L D E L D A V Q M D
Full Length
41.6 kDa
1 to 346
Recombinant
His tag N-Terminus
Liquid
ab180317 is purified using conventional chromatography techniques.
DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Common component of RNA polymerases I and III which synthesize ribosomal RNA precursors and short non-coding RNAs including 5S rRNA, snRNAs, tRNAs and miRNAs, respectively. POLR1C/RPAC1 is part of the polymerase core and may function as a clamp element that moves to open and close the cleft.
Belongs to the archaeal Rpo3/eukaryotic RPB3 RNA polymerase subunit family.
Nucleus
Blue Ice
1-2 weeks
+4°C
-20°C
Upon delivery aliquot
Avoid freeze / thaw cycle
This supplementary information is collated from multiple sources and compiled automatically.
POLR1C also known as RNA polymerase I and III subunit C functions as a component of RNA polymerases I and III essential for the synthesis of ribosomal RNA precursors and small RNAs. This protein weighs approximately 34.5 kDa and is found ubiquitously expressed in human tissues reflecting its fundamental role in cellular transcription machinery. POLR1C is a subunit important for these polymerases' proper assembly and function.
POLR1C participates in the formation of the RNA polymerase I and III complexes which are responsible for transcribing ribosomal RNA and small RNAs respectively. These processes are important for protein synthesis and cell growth. As part of these complexes POLR1C interacts with multiple other subunits to ensure the correct transcription of ribosomal RNA which forms the structural and functional core of ribosomes essential for translating mRNA into proteins.
POLR1C is integral to the transcription pathways specifically those conducted by RNA polymerases I and III. These pathways play an important role in the synthesis of ribosomal RNA and small RNAs which are critical for protein biosynthesis. In these processes the protein interacts with other components like RPA proteins as well as RPC5 highlighting its involvement in the transcription cycle critical for cellular function and maintenance.
POLR1C mutations have connections to Treacher Collins syndrome and hypomyelinating leukodystrophy. In Treacher Collins syndrome POLR1C interacts with proteins involved in ribosomal biogenesis disrupting this process and causing craniofacial development issues. Similarly in hypomyelinating leukodystrophy aberrations in ribosomal RNA synthesis contribute to neurological symptoms further implicating POLR1C’s pivotal role in transcription machinery and development.
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15% SDS-PAGE analysis of ab180317 (3μg)
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