Recombinant Human POLR2J3 protein (His tag N-Terminus)

Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

POLR2J3 also known as RNA polymerase II subunit J3 is a component of the RNA polymerase II (Pol II) complex which is responsible for synthesizing messenger RNA in eukaryotic cells. It has a molecular mass of approximately 13 kDa. This subunit is expressed mainly in various human tissues including liver kidney and skeletal muscle. Its expression levels can vary depending on the tissue type and cellular conditions.

Biological function summary

RNA polymerase II acts as a central player in the transcription machinery. POLR2J3 forms an integral part of this complex playing a role in the assembly and stability of the whole machinery. The Pol II complex contains several other key subunits among them POLR2A and POLR2B which together function to unwind DNA polymerize RNA and ensure appropriate processing and modification of the nascent transcript. Changes in POLR2J3 expression may affect Pol II function and influence gene expression patterns in cells.

Pathways

Transcription regulation and mRNA processing heavily involve the functioning of POLR2J3 within the Pol II complex. It supports the transcription of DNA to messenger RNA a critical step in the RNA polymerase enzyme pathway. POLR2J3 works closely with POLR2A among other subunits to coordinate this process ensuring the correct synthesis and modification of RNA. This protein's role within these pathways also connects it indirectly to signal transduction pathways that dictate cellular responses to different stimuli.

POLR2J3's role in transcription links it to potential involvement in cancer and neurodegenerative diseases. Errors in RNA polymerase II function which can arise from malfunctions within POLR2J3 have been observed in some cancer types due to defective cellular transcription processes. Furthermore alterations in transcription regulation possibly connected to POLR2J3 are implicated in neurological disorders where transcriptional dysregulation can lead to aberrant gene expression. Interactions between POLR2J3 and POLR2A during these processes suggest that both subunits might contribute to pathologies when their functions are compromised.