Recombinant Human POLR2K protein (His tag N-Terminus)

Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

POLR2K also known as Polymerase (RNA) II (DNA Directed) Polypeptide K is a subunit of the RNA polymerase II complex. This protein is involved in the transcription of DNA into mRNA. POLR2K has a molecular mass of approximately 7.52 kDa. It is expressed in various tissues throughout the body indicating its essential role in general cellular functions. The presence of POLR2K in different cell types emphasizes its importance in the transcription machinery.

Biological function summary

POLR2K is part of the larger RNA polymerase II complex which is important for the synthesis of messenger RNA in eukaryotic cells. It functions in conjunction with other subunits to enable the initiation and elongation phases of transcription. POLR2K contributes to the accurate and efficient transcription of genetic information ensuring proper gene expression and cellular function. As a component of this complex POLR2K plays a significant role in the gene expression process.

Pathways

The RNA polymerase II complex which includes POLR2K is an important player in the mRNA synthesis pathway. It is involved in the pathway for the synthesis of RNA from DNA templates often called the central dogma of molecular biology. POLR2K interacts with other subunits of RNA polymerase II such as RPB1 and RPB2 allowing for coordinated transcriptional regulation. This interaction underlines the integration of POLR2K within the transcriptional machinery.

Abnormal POLR2K function has been implicated in various pathological conditions. Dysregulation of the transcription machinery can contribute to cancer progression as evidence suggests involvement of POLR2K-related components. Its role in transcription aligns with disruptions in cellular homeostasis contributing to tumorigenesis. Additionally mutations affecting RNA polymerase II components including POLR2K can relate to neurodegenerative diseases like amyotrophic lateral sclerosis (ALS) highlighting the protein's role in maintaining neuronal function.