Recombinant human Polymeric immunoglobulin receptor/PIGR protein (Active) is a Human Fragment protein, in the 19 to 638 aa range, expressed in HEK 293, with >98% purity, < 0.1 EU/µg endotoxin level and suitable for SDS-PAGE, ELISA, FuncS.
K S P I F G P E E V N S V E G N S V S I T C Y Y P P T S V N R H T R K Y W C R Q G A R G G C I T L I S S E G Y V S S K Y A G R A N L T N F P E N G T F V V N I A Q L S Q D D S G R Y K C G L G I N S R G L S F D V S L E V S Q G P G L L N D T K V Y T V D L G R T V T I N C P F K T E N A Q K R K S L Y K Q I G L Y P V L V I D S S G Y V N P N Y T G R I R L D I Q G T G Q L L F S V V I N Q L R L S D A G Q Y L C Q A G D D S N S N K K N A D L Q V L K P E P E L V Y E D L R G S V T F H C A L G P E V A N V A K F L C R Q S S G E N C D V V V N T L G K R A P A F E G R I L L N P Q D K D G S F S V V I T G L R K E D A G R Y L C G A H S D G Q L Q E G S P I Q A W Q L F V N E E S T I P R S P T V V K G V A G G S V A V L C P Y N R K E S K S I K Y W C L W E G A Q N G R C P L L V D S E G W V K A Q Y E G R L S L L E E P G N G T F T V I L N Q L T S R D A G F Y W C L T N G D T L W R T T V E I K I I E G E P N L K V P G N V T A V L G E T L K V P C H F P C K F S S Y E K Y W C K W N N T G C Q A L P S Q D E G P S K A F V N C D E N S R L V S L T L N L V T R A D E G W Y W C G V K Q G H F Y G E T A A V Y V A V E E R K A A G S R D V S L A K A D A A P D E K V L D S G F R E I E N K A I Q D P R L F A E E K A V A D T R D Q A D G S R A S V D S G S S E E Q G G S S R
Application | Reactivity | Dilution info | Notes |
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Application SDS-PAGE | Reactivity Reacts | Dilution info - | Notes - |
Application ELISA | Reactivity Reacts | Dilution info - | Notes - |
Application FuncS | Reactivity Reacts | Dilution info - | Notes - |
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Polymeric immunoglobulin receptor. Mediates selective transcytosis of polymeric IgA and IgM across mucosal epithelial cells. Binds polymeric IgA and IgM at the basolateral surface of epithelial cells. The complex is then transported across the cell to be secreted at the apical surface. During this process, a cleavage occurs that separates the extracellular (known as the secretory component) from the transmembrane segment. Secretory component. Through its N-linked glycans ensures anchoring of secretory IgA (sIgA) molecules to mucus lining the epithelial surface to neutralize extracellular pathogens (PubMed:12150896). On its own (free form) may act as a non-specific microbial scavenger to prevent pathogen interaction with epithelial cells (PubMed:16543244).
Polymeric immunoglobulin receptor, PIgR, Poly-Ig receptor, Hepatocellular carcinoma-associated protein TB6, PIGR
Recombinant human Polymeric immunoglobulin receptor/PIGR protein (Active) is a Human Fragment protein, in the 19 to 638 aa range, expressed in HEK 293, with >98% purity, < 0.1 EU/µg endotoxin level and suitable for SDS-PAGE, ELISA, FuncS.
pH: 7.4
Constituents: 100% PBS
ab174011 was lyophilized from 0.22 µm filtered solution.
Polymeric immunoglobulin receptor
N-glycosylated. N-glycosylation is required for anchoring IgA molecules to mucus, but is not necessary for Ig binding.
This product is an active protein and may elicit a biological response in vivo, handle with caution.
Previously labelled as PIGR.
The polymeric immunoglobulin receptor often referred to as PIGR or the polymeric Ig receptor is a critical component in the immune system. This protein which has a mass of approximately 83 kDa is expressed primarily on the basolateral surface of epithelial cells. Common expression sites include the respiratory gastrointestinal and genital tracts. PIGR facilitates the transcytosis of polymeric immunoglobulins like IgA and IgM across epithelial cells ensuring that these antibodies reach mucosal sites where they perform functions.
The polymeric immunoglobulin receptor plays an essential role in mucosal immunity by transporting IgA and IgM antibodies to mucosal surfaces. The PIGR is a part of a complex that includes the secretory component which protects immunoglobulins from proteolytic degradation. This mechanism is fundamental for safeguarding mucosal surfaces while allowing the immune system to respond swiftly to pathogens.
The interaction of PIGR with polymeric immunoglobulins is an important event in the mucosal immune pathway. This pathway is important in maintaining mucosal homeostasis and pathogen defense. PIGR works closely with immunoglobulin proteins like IgA and IgM enabling their rapid and efficient transport across epithelial barriers. This ensures that the immune system rapidly addresses potential threats at mucosal sites.
Defects in PIGR function can lead to conditions like IgA nephropathy and selective IgA deficiency. These disorders highlight the importance of the polymeric Ig receptor in immune health and suggest its role in maintaining immunoglobulin balance. There is evidence suggesting potential connections between PIGR dysfunction and the proteins involved in immune regulation which helps in understanding how PIGR contributes to disease pathology.
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Human pIgR (His Tag) on SDS-PAGE under reducing (R) condition. The gel was stained overnight with Coomassie Blue. The purity of the protein is greater than 98%.
The purity of ab174011 was determined by reduced SDS-PAGE and staining overnight with Coomassie Blue.
DTT-reduced Protein migrates as 85-95 kDa due to glycosylation.
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