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AB108118

Recombinant Human POMC protein

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(4 Publications)

Recombinant Human POMC protein is a Human Full Length protein, in the 27 to 267 aa range, expressed in Escherichia coli, with >85%, suitable for SDS-PAGE, Mass Spec.

View Alternative Names

Pro-opiomelanocortin, POMC, Corticotropin-lipotropin

1 Images
SDS-PAGE - Recombinant Human POMC protein (AB108118)
  • SDS-PAGE

Unknown

SDS-PAGE - Recombinant Human POMC protein (AB108118)

15% SDS-PAGE showing ab108118 at approximately 28.9kDa (3μg).

Key facts

Purity

>85% SDS-PAGE

Expression system

Escherichia coli

Tags

His tag N-Terminus

Applications

Mass Spec, SDS-PAGE

applications

Biologically active

No

Accession

P01189

Animal free

No

Carrier free

No

Species

Human

Storage buffer

pH: 8.5 Constituents: 50% Glycerol (glycerin, glycerine), 1.16% Sodium chloride, 0.316% Tris HCl, 0.0154% (R*,R*)-1,4-Dimercaptobutan-2,3-diol

storage-buffer

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Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Reactivity", "Dilution Info", "Notes"] }, "values": { "SDS-PAGE": { "reactivity":"TESTED_AND_REACTS", "dilution-info":"", "notes":"<p></p>" }, "Mass Spec": { "reactivity":"TESTED_AND_REACTS", "dilution-info":"", "notes":"<p></p>" } } }
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Sequence info

[{"sequence":"MGSSHHHHHHSSGLVPRGSHMWCLESSQCQDLTTESNLLECIRACKPDLSAETPMFPGNGDEQPLTENPRKYVMGHFRWDRFGRRNSSSSGSSGAGQKREDVSAGEDCGPLPEGGPEPRSDGAKPGPREGKRSYSMEHFRWGKPVGKKRRPVKVYPNGAEDESAEAFPLEFKRELTGQRLREGDGPDGPADDGAGAQADLEHSLLVAAEKKDEGPYRMEHFRWGSPPKDKRYGGFMTSEKSQTPLVTLFKNAIIKNAYKKGE","proteinLength":"Full Length","predictedMolecularWeight":"28.9 kDa","actualMolecularWeight":null,"aminoAcidEnd":267,"aminoAcidStart":27,"nature":"Recombinant","expressionSystem":"Escherichia coli","accessionNumber":"P01189","tags":[{"tag":"His","terminus":"N-Terminus"}]}]
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Properties and storage information

Shipped at conditions
Blue Ice
Appropriate short-term storage conditions
-20°C
Appropriate long-term storage conditions
-20°C
Aliquoting information
Upon delivery aliquot
Storage information
Avoid freeze / thaw cycle
False
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Specifications

Form

Liquid

Additional notes

ab108118 is purified using conventional chromatography techniques.

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General info

Function

Corticotropin. Stimulates the adrenal glands to release cortisol.. Melanocyte-stimulating hormone alpha. Anorexigenic peptide. Increases the pigmentation of skin by increasing melanin production in melanocytes.. Melanocyte-stimulating hormone beta. Increases the pigmentation of skin by increasing melanin production in melanocytes.. Beta-endorphin. Endogenous orexigenic opiate.. Met-enkephalin. Endogenous opiate.

Sequence similarities

Belongs to the POMC family.

Post-translational modifications

Specific enzymatic cleavages at paired basic residues yield the different active peptides.. O-glycosylated; reducing sugar is probably N-acetylgalactosamine.

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Product protocols

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Target data

Corticotropin. Stimulates the adrenal glands to release cortisol.. Melanocyte-stimulating hormone alpha. Anorexigenic peptide. Increases the pigmentation of skin by increasing melanin production in melanocytes.. Melanocyte-stimulating hormone beta. Increases the pigmentation of skin by increasing melanin production in melanocytes.. Beta-endorphin. Endogenous orexigenic opiate.. Met-enkephalin. Endogenous opiate.
See full target information POMC
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Publications (4)

Recent publications for all applications. Explore the full list and refine your search

Frontiers in immunology 14:1284301 PubMed38035072

2023

Paraneoplastic isolated adrenocorticotropic hormone deficiency revealed after immune checkpoint inhibitors therapy: new insights into anti-corticotroph antibody.

Applications

Unspecified application

Species

Unspecified reactive species

Shin Urai,Miki Watanabe,Hironori Bando,Yuma Motomura,Masaaki Yamamoto,Motoko Tachihara,Maki Kanzawa,Hidenori Fukuoka,Genzo Iguchi,Wataru Ogawa

Nature communications 12:5991 PubMed34645803

2021

PGRMC1 acts as a size-selective cargo receptor to drive ER-phagic clearance of mutant prohormones.

Applications

Unspecified application

Species

Unspecified reactive species

Yu-Jie Chen,Jeffrey Knupp,Anoop Arunagiri,Leena Haataja,Peter Arvan,Billy Tsai

Addiction biology 26:e12856 PubMed31782234

2019

A history of opioid exposure in females increases the risk of metabolic disorders in their future male offspring.

Applications

Unspecified application

Species

Unspecified reactive species

Anika M Toorie,Fair M Vassoler,Fangfang Qu,Christopher M Schonhoff,Steven Bradburn,Christopher A Murgatroyd,Donna K Slonim,Elizabeth M Byrnes

PloS one 8:e56058 PubMed23457497

2013

Characterising the mechanism of airway smooth muscle β2 adrenoceptor desensitization by rhinovirus infected bronchial epithelial cells.

Applications

Unspecified application

Species

Unspecified reactive species

David Van Ly,Alen Faiz,Christine Jenkins,Ben Crossett,Judith L Black,Brent McParland,Janette K Burgess,Brian G G Oliver
View all publications
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Complementary Products

Biochemicals

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Biochemicals

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Secondary Antibodies

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Primary Antibodies

AB254257

Anti-POMC antibody [EPR22534-165]

BOND RX™ Validated|RabMAb|Recombinant

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