Recombinant Human PPAR alpha protein is a Human Full Length protein, in the 1 to 468 aa range, expressed in Escherichia coli, with >95% purity and suitable for SDS-PAGE, GSA, EMSA.
M V D T E S P L C P L S P L E A G D L E S P L S E E F L Q E M G N I Q E I S Q S I G E D S S G S F G F T E Y Q Y L G S C P G S D G S V I T D T L S P A S S P S S V T Y P V V P G S V D E S P S G A L N I E C R I C G D K A S G Y H Y G V H A C E G C K G F F R R T I R L K L V Y D K C D R S C K I Q K K N R N K C Q Y C R F H K C L S V G M S H N A I R F G R M P R S E K A K L K A E I L T C E H D I E D S E T A D L K S L A K R I Y E A Y L K N F N M N K V K A R V I L S G K A S N N P P F V I H D M E T L C M A E K T L V A K L V A N G I Q N K E A E V R I F H C C Q C T S V E T V T E L T E F A K A I P G F A N L D L N D Q V T L L K Y G V Y E A I F A M L S S V M N K D G M L V A Y G N G F I T R E F L K S L R K P F C D I M E P K F D F A M K F N A L E L D D S D I S L F V A A I I C C G D R P G L L N V G H I E K M Q E G I V H V L R L H L Q S N H P D D I F L F P K L L Q K M A D L R Q L V T E H A Q L V Q I I K K T E S D A A L H P L L Q E I Y R D M Y
| Application | Reactivity | Dilution info | Notes |
|---|---|---|---|
Application SDS-PAGE | Reactivity Reacts | Dilution info - | Notes - |
Application GSA | Reactivity Reacts | Dilution info - | Notes - |
Application EMSA | Reactivity Reacts | Dilution info - | Notes - |
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Ligand-activated transcription factor. Key regulator of lipid metabolism. Activated by the endogenous ligand 1-palmitoyl-2-oleoyl-sn-glycerol-3-phosphocholine (16:0/18:1-GPC). Activated by oleylethanolamide, a naturally occurring lipid that regulates satiety. Receptor for peroxisome proliferators such as hypolipidemic drugs and fatty acids. Regulates the peroxisomal beta-oxidation pathway of fatty acids. Functions as a transcription activator for the ACOX1 and P450 genes. Transactivation activity requires heterodimerization with RXRA and is antagonized by NR2C2. May be required for the propagation of clock information to metabolic pathways regulated by PER2.
NR1C1, PPAR, PPARA, Peroxisome proliferator-activated receptor alpha, PPAR-alpha, Nuclear receptor subfamily 1 group C member 1
Recombinant Human PPAR alpha protein is a Human Full Length protein, in the 1 to 468 aa range, expressed in Escherichia coli, with >95% purity and suitable for SDS-PAGE, GSA, EMSA.
pH: 7.9
Constituents: 20% Glycerol (glycerin, glycerine), 0.75% Potassium chloride, 0.316% Tris HCl, 0.0154% (R*,R*)-1,4-Dimercaptobutan-2,3-diol, 0.00584% EDTA
Ligand-activated transcription factor. Key regulator of lipid metabolism. Activated by the endogenous ligand 1-palmitoyl-2-oleoyl-sn-glycerol-3-phosphocholine (16:0/18:1-GPC). Activated by oleylethanolamide, a naturally occurring lipid that regulates satiety. Receptor for peroxisome proliferators such as hypolipidemic drugs and fatty acids. Regulates the peroxisomal beta-oxidation pathway of fatty acids. Functions as a transcription activator for the ACOX1 and P450 genes. Transactivation activity requires heterodimerization with RXRA and is antagonized by NR2C2. May be required for the propagation of clock information to metabolic pathways regulated by PER2.
Belongs to the nuclear hormone receptor family. NR1 subfamily.
Ubiquitinated by E3 ubiquitin-protein ligase HUWE1; leading to proteasomal degradation.
1 unit equals 1 nanogram of purified protein.
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