Recombinant Human PPP2R5A protein (GST tag N-Terminus)
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Recombinant Human PPP2R5A protein (GST tag N-Terminus) is a Human Full Length protein, in the 1 to 486 aa range, expressed in Wheat germ, suitable for ELISA, WB.
View Alternative Names
Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit alpha isoform, PP2A B subunit isoform B'-alpha, PP2A B subunit isoform B56-alpha, PP2A B subunit isoform PR61-alpha, PP2A B subunit isoform R5-alpha, PR61alpha, PPP2R5A
- SDS-PAGE
Unknown
SDS-PAGE - Recombinant Human PPP2R5A protein (GST tag N-Terminus) (AB159173)
ab159173 on a 12.5% SDS-PAGE stained with Coomassie Blue.
Complementary Products
Reactivity data
Sequence info
Properties and storage information
Shipped at conditions
Appropriate short-term storage conditions
Appropriate long-term storage conditions
Aliquoting information
Storage information
Supplementary information
This supplementary information is collated from multiple sources and compiled automatically.
Biological function summary
B56α plays an important role in modulating PP2A activity by influencing substrate specificity and subcellular localization. It is part of the heterotrimeric PP2A complex which also includes a catalytic and a scaffolding subunit. This complex serves critical functions in cell cycle regulation development and apoptosis. By binding specific substrates B56α mediates processes like dephosphorylation affecting signal transduction pathways.
Pathways
B56α is involved in the regulation of signaling pathways such as the Akt/mTOR and Wnt signaling pathways. In these pathways it interacts with proteins like Akt and GSK3β modulating their phosphorylation states and activities. By acting within these pathways B56α impacts processes such as cell growth survival and differentiation showcasing its significance in cellular homeostasis.
Specifications
Form
Liquid
General info
Function
The B regulatory subunit might modulate substrate selectivity and catalytic activity, and might also direct the localization of the catalytic enzyme to a particular subcellular compartment.
Sequence similarities
Belongs to the phosphatase 2A regulatory subunit B56 family.
Post-translational modifications
Phosphorylated on serine residues.
Subcellular localisation
Nucleus
Target data
Product promise
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