Recombinant Human PR3 protein
Be the first to review this product! Submit a review
|
(1 Publication)
Recombinant Human PR3 protein is a Human Full Length protein in the 26 to 249 aa range with >95% purity, < 1 EU/µg endotoxin level and suitable for SDS-PAGE and HPLC. The predicted molecular weight of ab153798 protein is 25.6 kDa.
- Save time and ensure accurate results - use our recombinant Human proteinase 3 (PR3) protein as a control
View Alternative Names
MBN, PRTN3, Myeloblastin, AGP7, C-ANCA antigen, Leukocyte proteinase 3, Neutrophil proteinase 4, P29, Wegener autoantigen, PR-3, PR3, NP-4
- SDS-PAGE
Unknown
SDS-PAGE - Recombinant Human PR3 protein (AB153798)
SDS-PAGE analysis using ab153798.
Predicted MW 26 kDa with tag.
Complementary Products
Reagents, Controls & Accessories
AB325996
Prestained Protein Ladder - Broad molecular weight (11-250 kDa, 5-color, 12 bands)
- 0
- 0
![Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-PR3 antibody [EPR6277] (AB133613)](https://content.abcam.com/products/images/pr3-antibody-epr6277-ab133613--immunohistochemistry-formalin-pfa-fixed-paraffin-embedded-sections-img104318.jpg)
Reactivity data
Product details
Check out our protein gel staining guide for SDS-PAGE here
Sequence info
Properties and storage information
Shipped at conditions
Appropriate short-term storage conditions
Appropriate long-term storage conditions
Aliquoting information
Storage information
Supplementary information
This supplementary information is collated from multiple sources and compiled automatically.
Biological function summary
Proteinase 3 serves multiple roles including modulating inflammation and immune responses. PR3 functions as part of a complex with azurophilic granules aiding in microbial defense mechanisms. In addition the protease regulates cytokine activation and deactivation which in turn influences cell signaling related to inflammation. Its enzymatic action ensures that PR3 can manage inflammatory processes by breaking down extracellular matrix components thereby allowing white blood cells to access infection sites.
Pathways
Proteinase 3 plays an important role within the serine protease and inflammatory pathways. It interacts with other proteins such as neutrophil elastase with which it shares a pathway to modulate immune responses. PR3 also partners with cathepsin G contributing to processes such as pathogen clearance and tissue remodeling providing a coordinated response during infection and injury. These interactions show PR3's involvement in regulating the balance between inflammation and tissue repair.
Specifications
Form
Liquid
Additional notes
Greater than 95% as determined by SEC-HPLC and reducing SDS-PAGE. Supplied as a 0.2 μM filtered solution.
General info
Function
Serine protease that degrades elastin, fibronectin, laminin, vitronectin, and collagen types I, III, and IV (in vitro) (PubMed : 2033050, PubMed : 28240246, PubMed : 3198760). By cleaving and activating receptor F2RL1/PAR-2, enhances endothelial cell barrier function and thus vascular integrity during neutrophil transendothelial migration (PubMed : 23202369). Plays a role in neutrophil transendothelial migration, probably when associated with CD177 (PubMed : 22266279). Triggers inflammatory processes in neutrophils by interacting with ADGRG3 upstream of F2RL1/PAR2 activation (PubMed : 36302784).
Sequence similarities
Belongs to the peptidase S1 family. Elastase subfamily.
Target data
Publications (1)
Recent publications for all applications. Explore the full list and refine your search
The FEBS journal 287:4068-4081 PubMed31995266
2020
Applications
Unspecified application
Species
Unspecified reactive species
Product promise
Please note: All products are 'FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC OR THERAPEUTIC PROCEDURES'.
For licensing inquiries, please contact partnerships@abcam.com