JavaScript is disabled in your browser. Please enable JavaScript to view this website.
AB276656

Recombinant Human PRAP1 protein (His tag)

Be the first to review this product! Submit a review

|

(0 Publication)

Recombinant Human PRAP1 protein (His tag) is a Human Full Length protein, in the 1 to 151 aa range, expressed in HEK 293 cells, with >90%, < 1 EU/µg endotoxin level, suitable for SDS-PAGE.

View Alternative Names

UPA, UNQ608/PRO1195, PRAP1, Proline-rich acidic protein 1, Epididymis tissue protein Li 178, Uterine-specific proline-rich acidic protein

1 Images
SDS-PAGE - Recombinant Human PRAP1 protein (His tag) (AB276656)
  • SDS-PAGE

Supplier Data

SDS-PAGE - Recombinant Human PRAP1 protein (His tag) (AB276656)

SDS-PAGE analysis of ab276656

Key facts

Purity

>90% SDS-PAGE

Endotoxin level

< 1 EU/µg

Expression system

HEK 293 cells

Tags

His tag C-Terminus

Applications

SDS-PAGE

applications

Biologically active

No

Accession

Q96NZ9

Animal free

No

Carrier free

No

Species

Human

Storage buffer

pH: 7.4 Constituents: 100% PBS

storage-buffer

style
left-column

Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Reactivity", "Dilution Info", "Notes"] }, "values": { "SDS-PAGE": { "reactivity":"TESTED_AND_REACTS", "dilution-info":"", "notes":"<p></p>" } } }
style
left-column
style
left-column

Sequence info

[{"sequence":"MRRLLLVTSLVVVLLWEAGAVPAPKVPIKMQVKHWPSEQDPEKAWGARVVEPPEKDDQLVVLFPVQKPKLLTTEEKPRGQGRGPILPGTKAWMETEDTLGHVLSPEPDHDSLYHPPPEEDQGEERPRLWVMPNHQVLLGPEEDQDHIYHPQ","proteinLength":"Full Length","predictedMolecularWeight":"16.4 kDa","actualMolecularWeight":null,"aminoAcidEnd":151,"aminoAcidStart":1,"nature":"Recombinant","expressionSystem":"HEK 293 cells","accessionNumber":"Q96NZ9","tags":[{"tag":"His","terminus":"C-Terminus"}]}]
style
left-column

Properties and storage information

Shipped at conditions
Ambient - Can Ship with Ice
Appropriate short-term storage conditions
-20°C
Appropriate long-term storage conditions
-20°C
Aliquoting information
Upon delivery aliquot
Storage information
Avoid freeze / thaw cycle
False
style
left-column

Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

PRAP1 sometimes referred to as Proline-Rich Acidic Protein 1 is a protein with a mass of approximately 18 kDa. It localizes mainly in the cell nucleus and has a restricted expression pattern found predominately in epithelial tissues such as the gastrointestinal tract and the reproductive system. This suggests that it might have functions related to those specific cell types.
Biological function summary

PRAP1 plays a role in cellular processes such as proliferation and differentiation. It does not seem to form part of any well-characterized multiprotein complex but its expression pattern implies a relevance in the development and maintenance of epithelial cells. Studies have suggested that PRAP1 may interact with various nuclear factors potentially influencing transcriptional regulation in specific tissue types.

Pathways

PRAP1's function involves processes that maintain epithelial integrity and renewal. It has associations with the Wnt signaling pathway which is important for regulating tissue homeostasis and cellular proliferation. PRAP1 may interact with proteins like β-catenin an important player in Wnt signaling although direct interactions remain experimentally undefined.

Research indicates PRAP1 could be implicated in cancer especially those originating from epithelial tissues like colorectal cancer. Alterations in PRAP1 expression and function might contribute to oncogenesis or tumor progression. Furthermore PRAP1 shows potential links to inflammatory disorders with altered activity potentially affecting proteins such as NF-κB a critical regulator in inflammatory responses.
style
left-column

Specifications

Form

Lyophilized

style
left-column

General info

Function

Lipid-binding protein which promotes lipid absorption by facilitating MTTP-mediated lipid transfer (mainly triglycerides and phospholipids) and MTTP-mediated apoB lipoprotein assembly and secretion (By similarity). Protects the gastrointestinal epithelium from irradiation-induced apoptosis (By similarity). May play an important role in maintaining normal growth homeostasis in epithelial cells (PubMed : 14583459). Involved in p53/TP53-dependent cell survival after DNA damage (PubMed : 23235459). May down-regulate the expression of MAD1L1 and exert a suppressive role in mitotic spindle assembly checkpoint in hepatocellular carcinomas (PubMed : 24374861).

style
left-column

Product protocols

style
left-column

Target data

Lipid-binding protein which promotes lipid absorption by facilitating MTTP-mediated lipid transfer (mainly triglycerides and phospholipids) and MTTP-mediated apoB lipoprotein assembly and secretion (By similarity). Protects the gastrointestinal epithelium from irradiation-induced apoptosis (By similarity). May play an important role in maintaining normal growth homeostasis in epithelial cells (PubMed : 14583459). Involved in p53/TP53-dependent cell survival after DNA damage (PubMed : 23235459). May down-regulate the expression of MAD1L1 and exert a suppressive role in mitotic spindle assembly checkpoint in hepatocellular carcinomas (PubMed : 24374861).
See full target information PRAP1
style
left-column
style
left-column
style
right-column

Complementary Products

Proteins & Peptides

AB241236

Recombinant Human YAP1 protein (His tag)

SDS-PAGE - Recombinant Human YAP1 protein (His tag) (AB241236)

  • 0
  • 0
Proteins & Peptides

AB276424

Recombinant Human VNN2 protein (His tag)

SDS-PAGE - Recombinant Human VNN2 protein (His tag) (AB276424)

  • 0
  • 0
Secondary Antibodies

AB125912

Rabbit monoclonal [H26-10] Anti-Human IgG1 H&L

RabMAb|Recombinant

ELISA - Rabbit monoclonal [H26-10] Anti-Human IgG1 H&L (AB125912)

  • 0
  • 0
Proteins & Peptides

AB181934

Recombinant Human ZNF32 protein (denatured)

SDS-PAGE - Recombinant Human ZNF32 protein (denatured) (AB181934)

  • 0
  • 0

Product promise

We are committed to supporting your work with high-quality reagents, and we're here for you every step of the way. In the unlikely event that one of our products does not perform as expected, you're protected by our Product Promise.
For full details, please see our Terms & Conditions

Please note: All products are 'FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC OR THERAPEUTIC PROCEDURES'.

For licensing inquiries, please contact partnerships@abcam.com