Recombinant Human PRDC protein is a Human Full Length protein, in the 1 to 168 aa range, expressed in Wheat germ and suitable for ELISA, WB.
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Key facts
- Expression system
- Wheat germ
- Tags
- GST tag N-Terminus
- Applications
- ELISA, WB
- Biologically active
- No
Amino acid sequence
M F W K L S L S L F M V A V L V K V A E A R K N R P A G A I H S P Y K D G S S N N S E R W Q H Q I K E V L A S S Q E A L V V T E R K Y L K S D W C K T Q P L R Q T V S E E G C R S R T I L N R F C C G Q C N S F Y I P R H V K K E E E S F Q S C A F C K P Q R V T S V L V E L E C P G L D P P F R L K K I Q K V K Q C R C M S V N L S D S D K Q
Reactivity data
| Application | Reactivity | Dilution info | Notes |
|---|---|---|---|
Application ELISA | Reactivity Reacts | Dilution info - | Notes - |
Application WB | Reactivity Reacts | Dilution info - | Notes - |
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Target data
Function
Cytokine that inhibits the activity of BMP2 and BMP4 in a dose-dependent manner, and thereby modulates signaling by BMP family members. Contributes to the regulation of embryonic morphogenesis via BMP family members. Antagonizes BMP4-induced suppression of progesterone production in granulosa cells.
Alternative names
CKTSF1B2, DAND3, PRDC, GREM2, Gremlin-2, DAN domain family member 3, Protein related to DAN and cerberus
Recommended products
Recombinant Human PRDC protein is a Human Full Length protein, in the 1 to 168 aa range, expressed in Wheat germ and suitable for ELISA, WB.
Key facts
- Expression system
- Wheat germ
- Tags
- GST tag N-Terminus
- Applications
- ELISA, WB
- Biologically active
- No
- Accession
- Q9H772-1
- Animal free
- No
- Species
- Human
- Concentration
- Storage buffer
pH: 8
Constituents: 0.79% Tris HCl, 0.31% Glutathione
Sequence info
Amino acid sequence
- M F W K L S L S L F M V A V L V K V A E A R K N R P A G A I H S P Y K D G S S N N S E R W Q H Q I K E V L A S S Q E A L V V T E R K Y L K S D W C K T Q P L R Q T V S E E G C R S R T I L N R F C C G Q C N S F Y I P R H V K K E E E S F Q S C A F C K P Q R V T S V L V E L E C P G L D P P F R L K K I Q K V K Q C R C M S V N L S D S D K Q
- Accession
- Q9H772
- Protein length
- Full Length
- Amino acids
- 1 to 168
- Nature
- Recombinant
- Tags
- GST tag N-Terminus
Specifications
- Form
- Liquid
General info
- Function
Cytokine that inhibits the activity of BMP2 and BMP4 in a dose-dependent manner, and thereby modulates signaling by BMP family members. Contributes to the regulation of embryonic morphogenesis via BMP family members. Antagonizes BMP4-induced suppression of progesterone production in granulosa cells.
- Sequence similarities
Belongs to the DAN family.
- Post-translational modifications
N-glycosylated.
Storage
- Shipped at conditions
- Dry Ice
- Appropriate short-term storage conditions
- -80°C
- Appropriate long-term storage conditions
- -80°C
- Aliquoting information
- Upon delivery aliquot
- Storage information
- Avoid freeze / thaw cycle
Notes
This product was previously labelled as GREM2.
Supplementary info
- This supplementary information is collated from multiple sources and compiled automatically.
- Activity summary
PRDC also known as protein related to DAN and cerberus or GREM2 is a member of the DAN family of cysteine knot secreted proteins. It weighs approximately 24 kDa. PRDC expresses in various tissues with strong presence in the heart lung and kidney among others. Its expression pattern suggests a role in organ development and tissue homeostasis. As a secreted protein PRDC exists outside the cell where it can interact with other molecules in the extracellular environment.
- Biological function summary
PRDC functions as an antagonist of bone morphogenetic proteins (BMPs) which are part of the TGF-beta superfamily. By inhibiting BMP signaling PRDC regulates cell differentiation and growth. This protein does not work alone; it often interacts within larger complexes that involve other members of the BMP family. Through this interaction PRDC plays a role in developmental processes and tissue regeneration.
- Pathways
PRDC integrates into key signaling cascades such as the BMP signaling pathway and TGF-beta pathway. It modulates the activity of BMPs directly affecting SMAD-dependent signaling. This role places it as a critical player in embryogenesis and organogenesis. Proteins like noggin and chordin also intersect with PRDC within these pathways working together to modulate cellular responses.
- Associated diseases and disorders
Altered PRDC function links to various conditions including fibrodysplasia ossificans progressiva (FOP) and pulmonary hypertension. These diseases highlight the importance of proper BMP signaling modulation by PRDC. In the context of FOP abnormal PRDC expression can exacerbate processes like heterotopic ossification. Proteins such as ACVR1 involved in BMP signaling exhibit interconnected roles with PRDC in these pathological conditions.
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1 product image
SDS-PAGE - Recombinant Human PRDC protein (ab163828)
ab163828 on a 12.5% SDS-PAGE stained with Coomassie Blue.
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