JavaScript is disabled in your browser. Please enable JavaScript to view this website.
AB196412

Recombinant Human PRDM12 protein

Be the first to review this product! Submit a review

|

(0 Publication)

Recombinant Human PRDM12 protein is a Human Fragment protein, in the 2 to 243 aa range, expressed in Escherichia coli, with >50%, suitable for SDS-PAGE.

View Alternative Names

PFM9, PRDM12, PR domain zinc finger protein 12, PR domain-containing protein 12

1 Images
SDS-PAGE - Recombinant Human PRDM12 protein (AB196412)
  • SDS-PAGE

Supplier Data

SDS-PAGE - Recombinant Human PRDM12 protein (AB196412)

4-20% SDS-PAGE analysis of 2 μg ab196412 with Coomassie staining.

Key facts

Purity

>50% SDS-PAGE

Expression system

Escherichia coli

Tags

GST tag N-Terminus

Applications

SDS-PAGE

applications

Biologically active

No

Accession

Q9H4Q4

Animal free

No

Carrier free

No

Species

Human

Storage buffer

pH: 8 Constituents: 20% Glycerol (glycerin, glycerine), 0.64% Sodium chloride, 0.63% Tris HCl, 0.04% Sorbitan monolaurate, ethoxylated, 0.02% Potassium chloride

storage-buffer

style
left-column

Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Reactivity", "Dilution Info", "Notes"] }, "values": { "SDS-PAGE": { "reactivity":"TESTED_AND_REACTS", "dilution-info":"", "notes":"<p></p>" } } }
style
left-column
style
left-column

Sequence info

[{"sequence":"MSPILGYWKIKGLVQPTRLLLEYLEEKYEEHLYERDEGDKWRNKKFELGLEFPNLPYYIDGDVKLTQSMAIIRYIADKHNMLGGCPKERAEISMLEGAVLDIRYGVSRIAYSKDFETLKVDFLSKLPEMLKMFEDRLCHKTYLNGDHVTHPDFMLYDALDVVLYMDPMCLDAFPKLVCFKKRIEAIPQIDKYLKSSKYIAWPLQGWQATFGGGDHPPKSDLEVLFQ^GPLGSMGSVLPAEALVLKTGLKAPGLALAEVITSDILHSFLYGRWRNVLGEQLFEDKSHHASPKTAFTAEVLAQSFSGEVQKLSSLVLPAEVIIAQSSIPGEGLGIFSKTWIKAGTEMGPFTGRVIAPEHVDICKNNNLMWEVFNEDGTVRYFIDASQEDHRSWMTYIKCARNEQEQNLEVVQIGTSIFYKAIEMIPPDQELLVWYGNSHNTFLGIPGVPGLEEDQKKNKHEDFHPADSAAGPAGRM","proteinLength":"Fragment","predictedMolecularWeight":"54 kDa","actualMolecularWeight":null,"aminoAcidEnd":243,"aminoAcidStart":2,"nature":"Recombinant","expressionSystem":"Escherichia coli","accessionNumber":"Q9H4Q4","tags":[{"tag":"GST","terminus":"N-Terminus"}]}]
style
left-column

Properties and storage information

Shipped at conditions
Dry Ice
Appropriate short-term storage conditions
-80°C
Appropriate long-term storage conditions
-80°C
Storage information
Avoid freeze / thaw cycle
False
style
left-column

Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

PRDM12 also known as PR domain containing 12 is a transcriptional regulator believed to have a mass of approximately 88 kDa. It functions mechanically by modulating gene expression through histone methylation. PRDM12 localizes in the nucleus and is primarily expressed in the nervous system notably in sensory neurons. It acts by interacting with other factors to influence the chromatin structure thereby modifying how genes get transcribed.
Biological function summary

PRDM12 plays a significant role in neural development and differentiation. It is a part of the PRDM family which is involved in various cellular processes through its interaction with cofactors. PRDM12 interacts to modulate neural gene expression contributing to the formation and maintenance of neural tissues. It does not function alone and requires protein partners forming complexes to execute its regulating tasks effectively within the cell.

Pathways

The activity of PRDM12 integrates into developmental signaling networks including the Notch and Wnt pathways. These pathways are critical for neural differentiation and cellular fate decision indicating PRDM12's involvement in neurogenesis. It interacts with proteins like Notch1 and β-catenin—key components in these pathways—to regulate downstream effects related to nerve cell specification and growth.

Mutations or dysregulation of PRDM12 have connections to congenital insensitivity to pain where patients cannot feel physical pain. This condition highlights PRDM12's importance in sensory neuron function. Another condition associated is peripheral neuropathy where the integrity of peripheral nerves is compromised. Here interactions with the TrkA protein which influences nerve growth factor receptor binding showcase PRDM12's role in disease contexts related to nerve health and functionality.
style
left-column

Specifications

Form

Liquid

style
left-column

General info

Function

Involved in the positive regulation of histone H3-K9 dimethylation.

Sequence similarities

Belongs to the class V-like SAM-binding methyltransferase superfamily.

Subcellular localisation

Nucleus

style
left-column

Product protocols

style
left-column

Target data

Involved in the positive regulation of histone H3-K9 dimethylation.
See full target information PRDM12
style
left-column
style
left-column
style
right-column

Complementary Products

Proteins & Peptides

AB313361

Recombinant Human WFDC2 Protein (His tag)

Mass Spectrometry - Recombinant Human WFDC2 Protein (His tag) (AB313361)

  • 0
  • 0
Proteins & Peptides

AB95933

Recombinant human XIAP protein

Functional Studies - Recombinant human XIAP protein (AB95933)

  • 0
  • 0
Proteins & Peptides

AB217407

Recombinant human Vitronectin/S-Protein (Animal Free)

  • 0
  • 0
Proteins & Peptides

AB216228

Recombinant human B7H4 protein (Fc Chimera Active)

Bioactive

  • 0
  • 0

Product promise

We are committed to supporting your work with high-quality reagents, and we're here for you every step of the way. In the unlikely event that one of our products does not perform as expected, you're protected by our Product Promise.
For full details, please see our Terms & Conditions

Please note: All products are 'FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC OR THERAPEUTIC PROCEDURES'.

For licensing inquiries, please contact partnerships@abcam.com