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AB196412

Recombinant Human PRDM12 protein (GST tag N-Terminus)

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Recombinant Human PRDM12 protein (GST tag N-Terminus) is a Human Fragment protein, in the 2 to 243 aa range, expressed in Escherichia coli, with >50%, suitable for SDS-PAGE.

View Alternative Names

PFM9, PRDM12, PR domain zinc finger protein 12, PR domain-containing protein 12

1 Images
SDS-PAGE - Recombinant Human PRDM12 protein (GST tag N-Terminus) (AB196412)
  • SDS-PAGE

Supplier Data

SDS-PAGE - Recombinant Human PRDM12 protein (GST tag N-Terminus) (AB196412)

4-20% SDS-PAGE analysis of 2 μg ab196412 with Coomassie staining.

Key facts

Purity

>50% SDS-PAGE

Expression system

Escherichia coli

Tags

GST tag N-Terminus

Applications

SDS-PAGE

applications

Biologically active

No

Accession

Q9H4Q4

Animal free

No

Carrier free

No

Species

Human

Storage buffer

pH: 8 Constituents: 20% Glycerol (glycerin, glycerine), 0.64% Sodium chloride, 0.63% Tris HCl, 0.04% Sorbitan monolaurate, ethoxylated, 0.02% Potassium chloride

storage-buffer

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Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Reactivity", "Dilution Info", "Notes"] }, "values": { "SDS-PAGE": { "reactivity":"TESTED_AND_REACTS", "dilution-info":"", "notes":"<p></p>" } } }
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Sequence info

[{"sequence":"MSPILGYWKIKGLVQPTRLLLEYLEEKYEEHLYERDEGDKWRNKKFELGLEFPNLPYYIDGDVKLTQSMAIIRYIADKHNMLGGCPKERAEISMLEGAVLDIRYGVSRIAYSKDFETLKVDFLSKLPEMLKMFEDRLCHKTYLNGDHVTHPDFMLYDALDVVLYMDPMCLDAFPKLVCFKKRIEAIPQIDKYLKSSKYIAWPLQGWQATFGGGDHPPKSDLEVLFQ^GPLGSMGSVLPAEALVLKTGLKAPGLALAEVITSDILHSFLYGRWRNVLGEQLFEDKSHHASPKTAFTAEVLAQSFSGEVQKLSSLVLPAEVIIAQSSIPGEGLGIFSKTWIKAGTEMGPFTGRVIAPEHVDICKNNNLMWEVFNEDGTVRYFIDASQEDHRSWMTYIKCARNEQEQNLEVVQIGTSIFYKAIEMIPPDQELLVWYGNSHNTFLGIPGVPGLEEDQKKNKHEDFHPADSAAGPAGRM","proteinLength":"Fragment","predictedMolecularWeight":"54 kDa","actualMolecularWeight":null,"aminoAcidEnd":243,"aminoAcidStart":2,"nature":"Recombinant","expressionSystem":"Escherichia coli","accessionNumber":"Q9H4Q4","tags":[{"tag":"GST","terminus":"N-Terminus"}]}]
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Properties and storage information

Shipped at conditions
Dry Ice
Appropriate short-term storage conditions
-80°C
Appropriate long-term storage conditions
-80°C
Storage information
Avoid freeze / thaw cycle
False
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Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

PRDM12 also known as PR domain containing 12 is a transcriptional regulator believed to have a mass of approximately 88 kDa. It functions mechanically by modulating gene expression through histone methylation. PRDM12 localizes in the nucleus and is primarily expressed in the nervous system notably in sensory neurons. It acts by interacting with other factors to influence the chromatin structure thereby modifying how genes get transcribed.
Biological function summary

PRDM12 plays a significant role in neural development and differentiation. It is a part of the PRDM family which is involved in various cellular processes through its interaction with cofactors. PRDM12 interacts to modulate neural gene expression contributing to the formation and maintenance of neural tissues. It does not function alone and requires protein partners forming complexes to execute its regulating tasks effectively within the cell.

Pathways

The activity of PRDM12 integrates into developmental signaling networks including the Notch and Wnt pathways. These pathways are critical for neural differentiation and cellular fate decision indicating PRDM12's involvement in neurogenesis. It interacts with proteins like Notch1 and β-catenin—key components in these pathways—to regulate downstream effects related to nerve cell specification and growth.

Mutations or dysregulation of PRDM12 have connections to congenital insensitivity to pain where patients cannot feel physical pain. This condition highlights PRDM12's importance in sensory neuron function. Another condition associated is peripheral neuropathy where the integrity of peripheral nerves is compromised. Here interactions with the TrkA protein which influences nerve growth factor receptor binding showcase PRDM12's role in disease contexts related to nerve health and functionality.
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Specifications

Form

Liquid

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General info

Function

Transcriptional regulator necessary for the development of nociceptive neurons, playing a key role in determining the nociceptive lineage from neural crest cell progenitors. Initiates neurogenesis and activates downstream pro-neuronal transcription factors, such as NEUROD1, BRN3A, and ISL1, specifically within nociceptive neurons, while repressing non-nociceptor cell fates. Essential for the proper function of nociceptors in adults, influencing both their excitability and their gene expression, thereby impacting how these neurons respond to various pain stimuli.

Sequence similarities

Belongs to the class V-like SAM-binding methyltransferase superfamily.

Subcellular localisation

Nucleus

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Product protocols

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Target data

Transcriptional regulator necessary for the development of nociceptive neurons, playing a key role in determining the nociceptive lineage from neural crest cell progenitors. Initiates neurogenesis and activates downstream pro-neuronal transcription factors, such as NEUROD1, BRN3A, and ISL1, specifically within nociceptive neurons, while repressing non-nociceptor cell fates. Essential for the proper function of nociceptors in adults, influencing both their excitability and their gene expression, thereby impacting how these neurons respond to various pain stimuli.
See full target information PRDM12
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