Recombinant human PRKACG protein

Supplementary info

This supplementary information is collated from multiple sources and compiled automatically.

Activity summary

PRKACG also known as Protein Kinase Catalytic Subunit Gamma or cAMP-dependent protein kinase catalytic subunit gamma is a protein involved in kinase activity. This protein has a molecular mass of approximately 40 kDa. PRKACG is expressed in several tissues with notably high expression levels in the brain and testis. It belongs to the protein kinase family and serves a role in transferring phosphate groups from ATP to specific serine or threonine residues on substrate proteins.

Biological function summary

This kinase plays a part in various cellular signaling processes particularly in the regulation of metabolism gene expression and cell differentiation. PRKACG forms part of the larger protein kinase A (PKA) complex which includes regulatory and additional catalytic subunits. This enables precise modulation of cellular responses to different signals important for maintaining homeostasis and responding to environmental changes.

Pathways

PRKACG participates in the cAMP signaling pathway and the long-term depression pathway. In the cAMP signaling pathway it acts with proteins like PRKAR1A and PRKAR2A which serve as regulatory subunits to transmit signals that affect cellular functions. The activation of PRKACG by cAMP leads to phosphorylation events that can change the activity of enzymes involved in energy metabolism and other cellular processes.

Associated diseases and disorders

PRKACG has connections to psychiatric disorders such as schizophrenia and neurological conditions like Huntington's disease. Alterations in cAMP signaling where PRKACG plays a role can link to these diseases. The interplay between PRKACG and proteins like PRKAR1A may disrupt cellular signaling contributing to the pathophysiology of these conditions.