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AB177671

Recombinant Human Procathepsin W protein (denatured)

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Recombinant Human Procathepsin W protein (denatured) is a Human Full Length protein, in the 22 to 376 aa range, expressed in Escherichia coli, with >85%, suitable for SDS-PAGE.

View Alternative Names

Cathepsin W, Lymphopain, CTSW

1 Images
SDS-PAGE - Recombinant Human Procathepsin W protein (denatured) (AB177671)
  • SDS-PAGE

Supplier Data

SDS-PAGE - Recombinant Human Procathepsin W protein (denatured) (AB177671)

15% SDS-PAGE analysis of ab177671 (3μg).

Key facts

Purity

>85% SDS-PAGE

Expression system

Escherichia coli

Tags

His tag N-Terminus

Applications

SDS-PAGE

applications

Biologically active

No

Accession

P56202

Animal free

No

Carrier free

No

Species

Human

Storage buffer

pH: 8 Constituents: 10% Glycerol (glycerin, glycerine), 2.4% Urea, 0.32% Tris HCl

storage-buffer

Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Reactivity", "Dilution Info", "Notes"] }, "values": { "SDS-PAGE": { "reactivity":"TESTED_AND_REACTS", "dilution-info":"", "notes":"<p></p>" } } }

Sequence info

[{"sequence":"MGSSHHHHHHSSGLVPRGSHMGSIRGPLRAQDLGPQPLELKEAFKLFQIQFNRSYLSPEEHAHRLDIFAHNLAQAQRLQEEDLGTAEFGVTPFSDLTEEEFGQLYGYRRAAGGVPSMGREIRSEEPEESVPFSCDWRKVAGAISPIKDQKNCNCCWAMAAAGNIETLWRISFWDFVDVSVQELLDCGRCGDGCHGGFVWDAFITVLNNSGLASEKDYPFQGKVRAHRCHPKKYQKVAWIQDFIMLQNNEHRIAQYLATYGPITVTINMKPLQLYRKGVIKATPTTCDPQLVDHSVLLVGFGSVKSEEGIWAETVSSQSQPQPPHPTPYWILKNSWGAQWGEKGYFRLHRGSNTCGITKFPLTARVQKPDMKPRVSCPP","proteinLength":"Full Length","predictedMolecularWeight":"42 kDa","actualMolecularWeight":null,"aminoAcidEnd":376,"aminoAcidStart":22,"nature":"Recombinant","expressionSystem":"Escherichia coli","accessionNumber":"P56202","tags":[{"tag":"His","terminus":"N-Terminus"}]}]

Properties and storage information

Shipped at conditions
Blue Ice
Appropriate short-term storage duration
1-2 weeks
Appropriate short-term storage conditions
+4°C
Appropriate long-term storage conditions
-20°C
Aliquoting information
Upon delivery aliquot
Storage information
Avoid freeze / thaw cycle
False

Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

Procathepsin W also known as Cathepsin W is a lysosomal cysteine protease with a molecular mass of approximately 35 kDa. This enzyme is mainly expressed in cells of the immune system specifically in cytotoxic T lymphocytes and natural killer cells. The expression of Procathepsin W in these cells suggests a role in cytolytic activity. The gene encoding this protease is located on chromosome 11 and shares homology with other members of the cathepsin family.
Biological function summary

Procathepsin W acts as part of the immune system's machinery for degrading proteins. Although it is not directly involved in any known complexes it functions within the acidic environment of lysosomes. As a protease Procathepsin W helps break down proteins into smaller peptides or amino acids enabling the immune system to process antigens or eliminate damaged proteins. Its activity in immune cells indicates its relevance to immune responses aiding in cell killing processes.

Pathways

Procathepsin W plays a role in the antigen processing and presentation pathway which is important for immune surveillance. It interacts with other proteins such as major histocompatibility complex (MHC) molecules to present peptides to T cells contributing to the adaptive immune response. The enzyme is also indirectly linked to apoptosis through its participation in protein degradation sharing this pathway with other proteases like caspases that facilitate programmed cell death.

Procathepsin W shows relevance in conditions involving the immune system. Alterations in its expression or function may contribute to immune-related disorders such as autoimmune diseases or certain types of cancer. Connections between Procathepsin W and proteins like granzyme B highlight its potential involvement in tumor surveillance and elimination by the immune system. Understanding these interactions can provide insight into therapeutic targets for modulating immune functions in related diseases.

Specifications

Form

Liquid

General info

Function

May have a specific function in the mechanism or regulation of T-cell cytolytic activity.. (Microbial infection) Plays a role during influenza virus infection in lungs cells ex vivo. Acts at the level of virus entering host cytoplasm from late endosome.

Sequence similarities

Belongs to the peptidase C1 family.

Product protocols

Target data

May have a specific function in the mechanism or regulation of T-cell cytolytic activity.. (Microbial infection) Plays a role during influenza virus infection in lungs cells ex vivo. Acts at the level of virus entering host cytoplasm from late endosome.
See full target information CTSW

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