Recombinant Human Profilin 4 protein

Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

Profilin 4 also known as PFN4 is a member of the profilin family which are small actin-binding proteins. It has a molecular mass of approximately 15 kDa. PFN4 mainly binds to monomeric actin aiding in actin polymerization and regulation of actin dynamics. It is expressed in various tissues with notable expression in the testes. PFN4 interacts with proline-rich sequences strengthening its role in cytoskeletal arrangements.

Biological function summary

Profilin 4 influences cellular movement by modulating the actin cytoskeleton. It is part of the actin-binding protein complex working with other proteins to coordinate filament formation. The protein's activity impacts cell shape and motility essential for processes like spermatogenesis where actin remodeling is necessary. Profilin 4 ensures balance and control in the actin cytoskeleton assembly.

Pathways

Profilin 4 participates in the regulation of actin cytoskeletal pathways and is involved in intracellular signaling. In these pathways it cooperates closely with proteins such as cofilin and gelsolin which also modify actin dynamics. PFN4 impacts the Rho GTPase signaling pathways essential for cytoskeletal reorganization and cell movement. This interaction highlights its significance in maintaining cellular architecture and motility.

Profilin 4 has associations with male infertility due to its significant role in spermatogenesis. Abnormal expression or mutations can disrupt actin dynamics important for sperm development leading to oligoasthenoteratospermia. Additionally PFN4 links to neurodegenerative disorders like Alzheimer's disease where actin cytoskeleton disruptions affect nerve cell functions. In these contexts Profilin 4 interacts with proteins implicated in these pathologies highlighting potential therapeutic targets within cytoskeletal and protofilaments networks.