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AB162833

Recombinant Human Proprotein convertase PC4 (GST tag N-Terminus)

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Recombinant Human Proprotein convertase PC4 (GST tag N-Terminus) is a Human Full Length protein, in the 1 to 242 aa range, expressed in Wheat germ, suitable for ELISA, WB.

View Alternative Names

PC4, UNQ2757/PRO6496, PCSK4, Proprotein convertase subtilisin/kexin type 4, Proprotein convertase 4

1 Images
SDS-PAGE - Recombinant Human Proprotein convertase PC4 (GST tag N-Terminus) (AB162833)
  • SDS-PAGE

Unknown

SDS-PAGE - Recombinant Human Proprotein convertase PC4 (GST tag N-Terminus) (AB162833)

ab162833 on a 12.5% SDS-PAGE stained with Coomassie Blue.

Key facts

Expression system

Wheat germ

Tags

GST tag N-Terminus

Applications

WB, ELISA

applications

Biologically active

No

Accession

Q6UW60

Animal free

No

Carrier free

No

Species

Human

Storage buffer

pH: 8 Constituents: 0.79% Tris HCl, 0.31% Glutathione

storage-buffer

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Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Reactivity", "Dilution Info", "Notes"] }, "values": { "ELISA": { "reactivity":"TESTED_AND_REACTS", "dilution-info":"", "notes":"<p></p>" }, "WB": { "reactivity":"TESTED_AND_REACTS", "dilution-info":"", "notes":"<p></p>" } } }
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Sequence info

[{"sequence":"MGTRSTLVAIRPLDVSTEGYNNWVFMSTHFWDENPQGVWTLGLENKGYYFNTGTLYRYTLLLYGTAEDMTARPTGPQVTSSACVQRDTEGLCQACDGPAYILGQLCLAYCPPRFFNHTRLVTAGPGHTAAPALRVCSSCHASCYTCRGGSPRDCTSCPPSSTLDQQQGSCMGPTTPDSRPRLRAAACPHHRCPASAMVLSLLAVTLGGPVLCGMSMDLPLYAWLSRARATPTKPQVWLPAGT","proteinLength":"Full Length","predictedMolecularWeight":null,"actualMolecularWeight":null,"aminoAcidEnd":242,"aminoAcidStart":1,"nature":"Recombinant","expressionSystem":"Wheat germ","accessionNumber":"Q6UW60","tags":[{"tag":"GST","terminus":"N-Terminus"}]}]
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Properties and storage information

Shipped at conditions
Dry Ice
Appropriate short-term storage conditions
-80°C
Appropriate long-term storage conditions
-80°C
Aliquoting information
Upon delivery aliquot
Storage information
Avoid freeze / thaw cycle
False
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Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

Proprotein convertase PC4 also known as PCSK4 is a serine protease that plays an important mechanistic role in the processing of proproteins. It has a molecular mass of approximately 59 kDa and processes precursor proteins into their active forms by cleaving at specific multibasic sites. PC4 is expressed in various tissues with significant levels found in reproductive tissues like the testis and ovary. By cleaving peptide precursors PC4 facilitates proper function and regulation of many proteins.
Biological function summary

Proprotein convertase PC4 is essential in the maturation of proteins involved in reproductive physiology. It is not part of a larger complex but functions independently to activate specific substrates. This protease participates in the processing of hormones and growth factors which are important for processes like fertilization and early embryonic development. PC4's activity ensures that the necessary proteins are available in their active forms at critical stages in development.

Pathways

PC4 operates within critical hormonal regulation and cell signaling pathways particularly those involved in reproduction. It is closely related to other proprotein convertases such as PC1/3 and PC2 which also play roles in hormone processing. The activity of PC4 influences the regulation of important reproductive hormones and signaling molecules ensuring appropriate cellular responses during reproductive events.

Proprotein convertase PC4 has been linked to infertility and certain reproductive disorders. Its malfunction may impact the processing of proteins important for reproductive success leading to these conditions. PC4's involvement in processing reproductive hormones connects it to proteins like inhibin and activin which play roles in fertility. Understanding PC4's function and regulation can provide insights into potential therapeutic approaches for reproductive health issues.
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Specifications

Form

Liquid

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General info

Function

Proprotein convertase involved in the processing of hormone and other protein precursors at sites comprised of pairs of basic amino acid residues (By similarity). In males, important for ADAM2 processing as well as other acrosomal proteins with roles in fertilization and critical for normal fertilization events such as sperm capacitation, acrosome reaction and binding of sperm to zona pellucida (By similarity). Also plays a role in female fertility, involved in the regulation of trophoblast migration and placental development, may be through the proteolytical processing and activation of proteins such as IGF2 (PubMed : 16040806). May also participate in folliculogenesis in the ovaries (By similarity).

Sequence similarities

Belongs to the peptidase S8 family. Furin subfamily.

Post-translational modifications

N-glycosylated.. Synthesized in the endoplasmic reticulum as a zymogen, is matured by autocatalytic cleavage between the prodomain and the catalytic domain.

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Product protocols

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Target data

Proprotein convertase involved in the processing of hormone and other protein precursors at sites comprised of pairs of basic amino acid residues (By similarity). In males, important for ADAM2 processing as well as other acrosomal proteins with roles in fertilization and critical for normal fertilization events such as sperm capacitation, acrosome reaction and binding of sperm to zona pellucida (By similarity). Also plays a role in female fertility, involved in the regulation of trophoblast migration and placental development, may be through the proteolytical processing and activation of proteins such as IGF2 (PubMed : 16040806). May also participate in folliculogenesis in the ovaries (By similarity).
See full target information PCSK4
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