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AB219434

Recombinant Human Prorenin protein (His tag)

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Recombinant Human Prorenin protein (His tag) is a Human Full Length protein, in the 24 to 406 aa range, expressed in Baculovirus infected insect cells, with >90%, < 1 EU/µg endotoxin level, suitable for SDS-PAGE.

View Alternative Names

Renin, Angiotensinogenase, REN

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SDS-PAGE - Recombinant Human Prorenin protein (His tag) (AB219434)
  • SDS-PAGE

Supplier Data

SDS-PAGE - Recombinant Human Prorenin protein (His tag) (AB219434)

15% SDS-PAGE analysis of ab219434 (3μg).

Key facts

Purity

>90% SDS-PAGE

Endotoxin level

< 1 EU/µg

Expression system

Baculovirus infected insect cells

Tags

His tag C-Terminus

Applications

SDS-PAGE

applications

Biologically active

No

Accession

P00797

Animal free

No

Carrier free

No

Species

Human

Storage buffer

pH: 7.4 Constituents: 90% PBS, 10% Glycerol (glycerin, glycerine)

storage-buffer

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Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Reactivity", "Dilution Info", "Notes"] }, "values": { "SDS-PAGE": { "reactivity":"TESTED_AND_REACTS", "dilution-info":"", "notes":"<p></p>" } } }
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Sequence info

[{"sequence":"LPTDTTTFKRIFLKRMPSIRESLKERGVDMARLGPEWSQPMKRLTLGNTTSSVILTNYMDTQYYGEIGIGTPPQTFKVVFDTGSSNVWVPSSKCSRLYTACVYHKLFDASDSSSYKHNGTELTLRYSTGTVSGFLSQDIITVGGITVTQMFGEVTEMPALPFMLAEFDGVVGMGFIEQAIGRVTPIFDNIISQGVLKEDVFSFYYNRDSENSQSLGGQIVLGGSDPQHYEGNFHYINLIKTGVWQIQMKGVSVGSSTLLCEDGCLALVDTGASYISGSTSSIEKLMEALGAKKRLFDYVVKCNEGPTLPDISFHLGGKEYTLTSADYVFQESYSSKKLCTLAIHAMDIPPPTGPTWALGATFIRKFYTEFDRRNNRIGFALARLEHHHHHH","proteinLength":"Full Length","predictedMolecularWeight":"43.3 kDa","actualMolecularWeight":null,"aminoAcidEnd":406,"aminoAcidStart":24,"nature":"Recombinant","expressionSystem":"Baculovirus infected insect cells","accessionNumber":"P00797","tags":[{"tag":"His","terminus":"C-Terminus"}]}]
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Properties and storage information

Shipped at conditions
Blue Ice
Appropriate short-term storage duration
1-2 weeks
Appropriate short-term storage conditions
+4°C
Appropriate long-term storage conditions
-20°C
Aliquoting information
Upon delivery aliquot
Storage information
Avoid freeze / thaw cycle
False
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Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

Prorenin also known as angiotensinogenase is a precursor form of renin. This protein plays a vital role in the renin-angiotensin system (RAS) which regulates blood pressure and electrolyte balance. Prorenin is primarily synthesized in the juxtaglomerular cells of the kidney and possesses a molecular weight of approximately 40 kDa. It exists in an inactive form until it is cleaved to form active renin. It moves through the bloodstream to reach target tissues.
Biological function summary

Prorenin initiates the conversion of angiotensinogen to angiotensin I an important step in the RAS. In its inactive form prorenin circulates throughout the body but remains ready for activation. The activation involves a non-proteolytic conformational change or proteolytic cleavage within the kidneys. Prorenin may exist as part of a complex with the (pro)renin receptor which influences various physiological processes beyond blood pressure regulation.

Pathways

This precursor functions as an important regulator within the renin-angiotensin system. Prorenin by forming renin is directly involved with the conversion of angiotensinogen into angiotensin I. This initial step leads to further pathways that construct angiotensin II a potent vasoconstrictor affecting the vascular system. The activity of angiotensin II ties closely to the actions of the enzyme angiotensin-converting enzyme (ACE) which transforms angiotensin I to angiotensin II.

Prorenin's activation links strongly to conditions such as hypertension and diabetic nephropathy. Elevated prorenin levels have been observed in individuals with hypertension indicating its central role in this disorder. Furthermore its interaction with the (pro)renin receptor contributes to the progression of renal disease in diabetes-related nephropathy. The relationship among prorenin renin and the (pro)renin receptor provides significant implications for therapeutic strategies targeting these conditions.
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Specifications

Form

Liquid

Additional notes

Affinity purified

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General info

Function

Renin is a highly specific endopeptidase, whose only known function is to generate angiotensin I from angiotensinogen in the plasma, initiating a cascade of reactions that produce an elevation of blood pressure and increased sodium retention by the kidney.

Sequence similarities

Belongs to the peptidase A1 family.

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Product protocols

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Target data

Renin is a highly specific endopeptidase, whose only known function is to generate angiotensin I from angiotensinogen in the plasma, initiating a cascade of reactions that produce an elevation of blood pressure and increased sodium retention by the kidney.
See full target information REN
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