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AB132957

Recombinant Human Prostaglandin E Receptor EP2/PTGER2 protein (GST tag N-Terminus)

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Recombinant Human Prostaglandin E Receptor EP2/PTGER2 protein (GST tag N-Terminus) is a Human Full Length protein, in the 1 to 358 aa range, expressed in Wheat germ, suitable for SDS-PAGE, ELISA, WB.

View Alternative Names

Prostaglandin E2 receptor EP2 subtype, PGE receptor EP2 subtype, PGE2 receptor EP2 subtype, Prostanoid EP2 receptor, PTGER2

1 Images
SDS-PAGE - Recombinant Human Prostaglandin E Receptor EP2/PTGER2 protein (GST tag N-Terminus) (AB132957)
  • SDS-PAGE

Unknown

SDS-PAGE - Recombinant Human Prostaglandin E Receptor EP2/PTGER2 protein (GST tag N-Terminus) (AB132957)

12.5% SDS-PAGE analysis of ab132957 stained with Coomassie Blue.

Key facts

Expression system

Wheat germ

Tags

GST tag N-Terminus

Applications

WB, SDS-PAGE, ELISA

applications

Biologically active

No

Accession

P43116

Animal free

No

Carrier free

No

Species

Human

Storage buffer

pH: 8 Constituents: 0.79% Tris HCl, 0.31% Glutathione

storage-buffer

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Complementary Products

Proteins & Peptides

AB132115

Recombinant Human PGE2 receptor EP4 subtype protein (GST tag N-Terminus)

SDS-PAGE - Recombinant Human PGE2 receptor EP4 subtype protein (AB132115)

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Primary Antibodies

AB217966

Anti-PGE2 receptor EP4 subtype antibody

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-PGE2 receptor EP4 subtype antibody (AB217966)

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Biochemicals

AB141312

Nomega-Nitro-L-arginine (L-NNA), Nitric oxide synthase inhibitor

Chemical Structure - Nomega-Nitro-L-arginine (L-NNA), Nitric oxide synthase inhibitor (AB141312)

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  • 0
Primary Antibodies

AB180589

Anti-Prostaglandin E Synthase/MPGES-1 antibody [EPR13765]

RabMAb|Recombinant

Western blot - Anti-Prostaglandin E Synthase/MPGES-1 antibody [EPR13765] (AB180589)

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  • 0
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Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Reactivity", "Dilution Info", "Notes"] }, "values": { "SDS-PAGE": { "reactivity":"TESTED_AND_REACTS", "dilution-info":"", "notes":"<p></p>" }, "ELISA": { "reactivity":"TESTED_AND_REACTS", "dilution-info":"", "notes":"<p></p>" }, "WB": { "reactivity":"TESTED_AND_REACTS", "dilution-info":"", "notes":"<p></p>" } } }
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Product details

This product was previously labelled as Prostaglandin E Receptor EP2.
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Sequence info

[{"sequence":"MGNASNDSQSEDCETRQWLPPGESPAISSVMFSAGVLGNLIALALLARRWRGDVGCSAGRRSSLSLFHVLVTELVFTDLLGTCLISPVVLASYARNQTLVALAPESRACTYFAFAMTFFSLATMLMLFAMALERYLSIGHPYFYQRRVSRSGGLAVLPVIYAVSLLFCSLPLLDYGQYVQYCPGTWCFIRHGRTAYLQLYATLLLLLIVSVLACNFSVILNLIRMHRRSRRSRCGPSLGSGRGGPGARRRGERVSMAEETDHLILLAIMTITFAVCSLPFTIFAYMNETSSRKEKWDLQALRFLSINSIIDPWVFAILRPPVLRLMRSVLCCRISLRTQDATQTSCSTQSDASKQADL","proteinLength":"Full Length","predictedMolecularWeight":"66.2 kDa","actualMolecularWeight":null,"aminoAcidEnd":358,"aminoAcidStart":1,"nature":"Recombinant","expressionSystem":"Wheat germ","accessionNumber":"P43116","tags":[{"tag":"GST","terminus":"N-Terminus"}]}]
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Properties and storage information

Shipped at conditions
Dry Ice
Appropriate short-term storage conditions
-80°C
Appropriate long-term storage conditions
-80°C
Aliquoting information
Upon delivery aliquot
Storage information
Avoid freeze / thaw cycle
False
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Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

Prostaglandin E Receptor EP2 also known as PTGER2 or EP2 receptor is a G-protein coupled receptor with a molecular mass of approximately 53 kDa. This receptor primarily binds prostaglandin E2 (PGE2) mediating various cellular responses. EP2 receptor is expressed in tissues such as the brain kidneys lungs and immune cells. Its activation leads to the stimulation of adenylyl cyclase increasing levels of cyclic AMP (cAMP) within the cell.
Biological function summary

The EP2 receptor plays a role in vasodilation immune modulation and regulation of pain and inflammation. It does not act as part of a large protein complex but rather exerts its effects individually through its coupling with G-proteins. EP2 receptor stimulation results in smooth muscle relaxation and has implications in neuroinflammation and renal function.

Pathways

The EP2 receptor is involved in the prostaglandin signaling pathway and contributes to the inflammatory response pathway. It shares a connection with other receptors such as EP1 EP3 and EP4 which also bind PGE2 but induce different cellular responses. These pathways integrate signals that modulate processes like inflammation and immune responses highlighting EP2's role in maintaining physiological balance.

EP2 receptor activity is associated with conditions like asthma and Alzheimer's disease. In asthma the receptor's activity may influence airway hyperresponsiveness through its effects on smooth muscle and immune cells. In Alzheimer's EP2 receptor-related pathways may contribute to neuroinflammation which is linked with disease progression. Connections with proteins like COX-2 can be noted in these disorders as COX-2-dependent prostaglandin synthesis directly affects EP2 receptor signaling and subsequent cellular outcomes.
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Specifications

Form

Liquid

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General info

Function

Receptor for prostaglandin E2 (PGE2). The activity of this receptor is mediated by G(s) proteins that stimulate adenylate cyclase. The subsequent raise in intracellular cAMP is responsible for the relaxing effect of this receptor on smooth muscle.

Sequence similarities

Belongs to the G-protein coupled receptor 1 family.

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Product protocols

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Target data

Receptor for prostaglandin E2 (PGE2). The activity of this receptor is mediated by G(s) proteins that stimulate adenylate cyclase. The subsequent raise in intracellular cAMP is responsible for the relaxing effect of this receptor on smooth muscle.
See full target information Prostaglandin E2 receptor EP2 subtype
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