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AB159276

Recombinant Human Prostaglandin F2 alpha Receptor/PTGFR protein

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Recombinant Human Prostaglandin F2 alpha Receptor/PTGFR protein is a Human Full Length protein, in the 1 to 359 aa range, expressed in Wheat germ, suitable for ELISA, WB.

View Alternative Names

Prostaglandin F2-alpha receptor, PGF receptor, PGF2-alpha receptor, Prostanoid FP receptor, PTGFR

1 Images
SDS-PAGE - Recombinant Human Prostaglandin F2 alpha Receptor/PTGFR protein (AB159276)
  • SDS-PAGE

Unknown

SDS-PAGE - Recombinant Human Prostaglandin F2 alpha Receptor/PTGFR protein (AB159276)

ab159276 on a 12.5% SDS-PAGE stained with Coomassie Blue.

Key facts

Expression system

Wheat germ

Tags

GST tag N-Terminus

Applications

WB, ELISA

applications

Biologically active

No

Accession

P43088

Animal free

No

Carrier free

No

Species

Human

Storage buffer

pH: 8 Constituents: 0.79% Tris HCl, 0.31% Glutathione

storage-buffer

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Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Reactivity", "Dilution Info", "Notes"] }, "values": { "ELISA": { "reactivity":"TESTED_AND_REACTS", "dilution-info":"", "notes":"<p></p>" }, "WB": { "reactivity":"TESTED_AND_REACTS", "dilution-info":"", "notes":"<p></p>" } } }
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Product details

This product was previously labelled as Prostaglandin F2 alpha Receptor.
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Sequence info

[{"sequence":"MSMNNSKQLVSPAAALLSNTTCQTENRLSVFFSVIFMTVGILSNSLAIAILMKAYQRFRQKSKASFLLLASGLVITDFFGHLINGAIAVFVYASDKEWIRFDQSNVLCSIFGICMVFSGLCPLLLGSVMAIERCIGVTKPIFHSTKITSKHVKMMLSGVCLFAVFIALLPILGHRDYKIQASRTWCFYNTEDIKDWEDRFYLLLFSFLGLLALGVSLLCNAITGITLLRVKFKSQQHRQGRSHHLEMVIQLLAIMCVSCICWSPFLVTMANIGINGNHSLETCETTLFALRMATWNQILDPWVYILLRKAVLKNLYKLASQCCGVHVISLHIWELSSIKNSLKVAAISESPVAEKSAST","proteinLength":"Full Length","predictedMolecularWeight":null,"actualMolecularWeight":null,"aminoAcidEnd":359,"aminoAcidStart":1,"nature":"Recombinant","expressionSystem":"Wheat germ","accessionNumber":"P43088","tags":[{"tag":"GST","terminus":"N-Terminus"}]}]
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Properties and storage information

Shipped at conditions
Dry Ice
Appropriate short-term storage conditions
-80°C
Appropriate long-term storage conditions
-80°C
Aliquoting information
Upon delivery aliquot
Storage information
Avoid freeze / thaw cycle
False
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Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

The Prostaglandin F2 alpha Receptor also known as PTGFR is a G-protein-coupled receptor with a molecular mass of about 66 kDa. This receptor plays an essential role in mediating the effects of prostaglandin F2 alpha (PGF2α) a lipid compound involved in various physiological processes. The receptor is mainly expressed in tissues such as the uterus eye and vascular smooth muscle. Its localization allows it to actively participate in reproductive functions and other biological activities in these tissues.
Biological function summary

Prostaglandin F2 alpha Receptor functions as part of the prostanoid receptor family which mediates diverse physiological responses. PGF2α binding to the PTGFR induces intracellular signaling cascades that lead to smooth muscle contraction and modulation of inflammation. The receptor is not known to be part of any higher-order complex but interacts with intracellular signaling molecules to exert its effects. Its activity is important in processes such as luteolysis and modulation of intraocular pressure.

Pathways

The Prostaglandin F2 alpha Receptor is involved in key regulatory pathways like the prostaglandin signaling pathway and the smooth muscle contraction pathway. Within the prostaglandin signaling pathway PTGFR works with proteins such as phospholipase C to increase intracellular calcium levels leading to smooth muscle contraction. Its role in these pathways highlights its function in reproductive cycles and maintenance of cardiovascular health.

The Prostaglandin F2 alpha Receptor has associations with conditions such as glaucoma and dysmenorrhea. In glaucoma the receptor's role in modulating intraocular pressure links it to elevated pressure and optic nerve damage. Similarly dysmenorrhea involves excessive uterine muscle contractions where PTGFR-mediated signaling becomes heightened. The receptor's interaction with other proteins like cyclooxygenase-2 (COX-2) exacerbates these conditions by influencing prostaglandin production and signaling.
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Specifications

Form

Liquid

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General info

Function

Receptor for prostaglandin F2-alpha (PGF2-alpha). The activity of this receptor is mediated by G proteins which activate a phosphatidylinositol-calcium second messenger system. Initiates luteolysis in the corpus luteum (By similarity). Isoforms 2 to 7 do not bind PGF2-alpha but are proposed to modulate signaling by participating in variant receptor complexes; heterodimers between isoform 1 and isoform 5 are proposed to be a receptor for prostamides including the synthetic analog bimatoprost.

Sequence similarities

Belongs to the G-protein coupled receptor 1 family.

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Product protocols

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Target data

Receptor for prostaglandin F2-alpha (PGF2-alpha). The activity of this receptor is mediated by G proteins which activate a phosphatidylinositol-calcium second messenger system. Initiates luteolysis in the corpus luteum (By similarity). Isoforms 2 to 7 do not bind PGF2-alpha but are proposed to modulate signaling by participating in variant receptor complexes; heterodimers between isoform 1 and isoform 5 are proposed to be a receptor for prostamides including the synthetic analog bimatoprost.
See full target information Prostaglandin F2-alpha receptor
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Complementary Products

Primary Antibodies

AB126709

Anti-Prostaglandin F2 alpha Receptor/PTGFR antibody [EPR5844]

RabMAb|Recombinant

Western blot - Anti-Prostaglandin F2 alpha Receptor/PTGFR antibody [EPR5844] (AB126709)

  • 0
  • 0
Primary Antibodies

AB179800

Anti-COX2 / Cyclooxygenase 2 antibody [EPR12012]

KO Validated|RabMAb|Recombinant|Lab Essentials|20ul selling size

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-COX2 / Cyclooxygenase 2 antibody [EPR12012] (AB179800)

  • 4
  • 3
Primary Antibodies

AB75846

Anti-TRIB3 antibody [EPR3151Y]

RabMAb|Recombinant|KO Validated

Immunoprecipitation - Anti-TRIB3 antibody [EPR3151Y] (AB75846)

  • 5
  • 1
Primary Antibodies

AB255828

Anti-FHL1 antibody [EPR22842-95]

BOND RX™ Validated|RabMAb|Recombinant|KO Validated

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-FHL1 antibody [EPR22842-95] (AB255828)

  • 0
  • 0

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