Recombinant Human Proteasome 20S beta 3 protein (His tag N-Terminus)
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Recombinant Human Proteasome 20S beta 3 protein (His tag N-Terminus) is a Human Full Length protein, in the 1 to 246 aa range, expressed in Escherichia coli, with >90%, suitable for SDS-PAGE, Mass Spec.
View Alternative Names
Proteasome subunit beta type-3, Proteasome chain 13, Proteasome component C10-II, Proteasome subunit beta-3, Proteasome theta chain, beta-3, PSMB3
- SDS-PAGE
Supplier Data
SDS-PAGE - Recombinant Human Proteasome 20S beta 3 protein (His tag N-Terminus) (AB117227)
SDS-PAGE analysis of ab117227 (3µg).
- SDS-PAGE
Unknown
SDS-PAGE - Recombinant Human Proteasome 20S beta 3 protein (His tag N-Terminus) (AB117227)
15% SDS-PAGE showing ab117227 at approximately 25.1kDa (3μg).
Reactivity data
Sequence info
Properties and storage information
Shipped at conditions
Appropriate short-term storage duration
Appropriate short-term storage conditions
Appropriate long-term storage conditions
Aliquoting information
Storage information
Supplementary information
This supplementary information is collated from multiple sources and compiled automatically.
Biological function summary
Proteasome 20S beta 3 contributes to the assembly and function of the 26S proteasome complex. This complex facilitates the regulated degradation of intracellular proteins a process critical for various cellular processes including the cell cycle apoptosis and DNA repair. Proteasome 20S beta 3 is one of the 14 different subunits that make up the beta rings of the 20S core particle engaging in precise proteolytic activity within cells.
Pathways
Proteasome 20S beta 3 is essential in the ubiquitin-proteasome pathway a major pathway for protein catabolism. This pathway maintains protein equilibrium and modulates proteins involved in immune response and signal transduction. It closely interacts with ubiquitin ligases which tag proteins for degradation and connects to key pathways like the NF-kB signaling pathway where it can influence inflammatory responses due to its role in processing specific intracellular proteins.
Specifications
Form
Liquid
Additional notes
ab117227 is purified using conventional chromatography techniques.
General info
Function
Non-catalytic component of the 20S core proteasome complex involved in the proteolytic degradation of most intracellular proteins. This complex plays numerous essential roles within the cell by associating with different regulatory particles. Associated with two 19S regulatory particles, forms the 26S proteasome and thus participates in the ATP-dependent degradation of ubiquitinated proteins. The 26S proteasome plays a key role in the maintenance of protein homeostasis by removing misfolded or damaged proteins that could impair cellular functions, and by removing proteins whose functions are no longer required. Associated with the PA200 or PA28, the 20S proteasome mediates ubiquitin-independent protein degradation. This type of proteolysis is required in several pathways including spermatogenesis (20S-PA200 complex) or generation of a subset of MHC class I-presented antigenic peptides (20S-PA28 complex).
Sequence similarities
Belongs to the peptidase T1B family.
Subcellular localisation
Nucleus
Target data
Complementary Products
Product promise
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