Recombinant Human Protein FAM19A5
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Recombinant Human Protein FAM19A5 is a Human Fragment protein, in the 26 to 125 aa range, expressed in Escherichia coli, with >95%, < 1 EU/µg endotoxin level, suitable for SDS-PAGE, ELISA, WB, Mass Spec.
View Alternative Names
FAM19A5, UNQ5208/PRO34524, TAFA5, Chemokine-like protein TAFA-5
- SDS-PAGE
Supplier Data
SDS-PAGE - Recombinant Human Protein FAM19A5 (AB203547)
14% SDS-PAGE separation of ab203547.
1. M.W. marker – 14, 21, 31, 45, 66, 97 kDa
2. Reduced and heated sample, 2.5μg / lane
3. Non-reduced and non-heated sample, 2.5μg / lane
ab203547 migrates as two significant bands corresponding to molecular mass 10kDa and 14kDa, respectively. Both bands were confirmed by LC-MS/MS and identified as FAM19A5.
Reactivity data
Sequence info
Properties and storage information
Shipped at conditions
Appropriate short-term storage conditions
Appropriate long-term storage conditions
Aliquoting information
Storage information
Supplementary information
This supplementary information is collated from multiple sources and compiled automatically.
Biological function summary
The FAM19A5 protein influences neuroinflammatory processes and modulates the activity of neurons. While it does not form part of a large protein complex it may interact with extracellular matrix components to exert its effects. Its function is linked to the modulation of neural signaling indicating its role in maintaining homeostasis within the neural networks.
Pathways
This protein is known to engage with critical signaling cascades implicated in the central nervous system. In particular FAM19A5 is associated with the regulation of the chemokine signaling pathway. It is linked to pathways also involving proteins such as CCR5 and CXCR3 which interact in chemotaxis and influence neural cell responses. These pathways help in communicating signals that guide neural cell behavior affecting motor coordination and cognitive functions.
Specifications
Form
Liquid
General info
Function
Acts as a chemokine-like protein by regulating cell proliferation and migration through activation of G protein-coupled receptors (GPCRs), such as S1PR2 and FPR2 (By similarity). Stimulates chemotactic migration of macrophages mediated by the MAPK3/ERK1 and AKT1 pathway (By similarity). Blocks TNFSF11/RANKL-induced osteoclast formation from macrophages by inhibiting up-regulation of osteoclast fusogenic and differentiation genes (By similarity). Stimulation of macrophage migration and inhibition of osteoclast formation is mediated via GPCR FPR2 (By similarity). Acts as an adipokine by negatively regulating vascular smooth muscle cell (VSMC) proliferation and migration in response to platelet-derived growth factor stimulation via GPCR S1PR2 and G protein GNA12/GNA13-transmitted RHOA signaling (By similarity). Inhibits injury-induced cell proliferation and neointima formation in the femoral arteries (By similarity).
Sequence similarities
Belongs to the TAFA family.
Target data
Complementary Products
Product promise
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