JavaScript is disabled in your browser. Please enable JavaScript to view this website.
AB179953

Recombinant Human Protein kinase Y linked

Be the first to review this product! Submit a review

|

(0 Publication)

Recombinant Human Protein kinase Y linked is a Human Fragment protein, in the 40 to 277 aa range, expressed in Baculovirus infected Sf9 cells, with >75%, suitable for SDS-PAGE, WB.

View Alternative Names

Putative serine/threonine-protein kinase PRKY, PRKY

1 Images
SDS-PAGE - Recombinant Human Protein kinase Y linked (AB179953)
  • SDS-PAGE

Supplier Data

SDS-PAGE - Recombinant Human Protein kinase Y linked (AB179953)

SDS-PAGE analysis of ab179953.

Key facts

Purity

>75% Densitometry

Expression system

Baculovirus infected Sf9 cells

Tags

GST tag N-Terminus

Applications

WB, SDS-PAGE

applications

Biologically active

No

Accession

O43930

Animal free

No

Carrier free

No

Species

Human

Storage buffer

pH: 7.5 Constituents: 25% Glycerol (glycerin, glycerine), 0.79% Tris HCl, 0.31% Glutathione, 0.29% Sodium chloride, 0.004% (R*,R*)-1,4-Dimercaptobutan-2,3-diol, 0.003% EDTA, 0.002% PMSF

storage-buffer

style
left-column

Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Reactivity", "Dilution Info", "Notes"] }, "values": { "SDS-PAGE": { "reactivity":"TESTED_AND_REACTS", "dilution-info":"", "notes":"<p></p>" }, "WB": { "reactivity":"TESTED_AND_REACTS", "dilution-info":"", "notes":"<p></p>" } } }
style
left-column
style
left-column

Sequence info

[{"sequence":"EAPAYRLQDCDALVTMGTGTFGRVHLVKEKTAKHFFALKVMSIPDVIRRKQEQHVHNEKSVLKEVSHPFLIRLFWTWHEERFLYMLMEYVPGGELFSYLRNRGHFSSTTGLFYSAEIICAIEYLHSKEIVYRDLKPENILLDRDGHIKLTDFGFAKKLVDRTWTLCGTPEYLAPEVIQSKGHGRAVDWWALGILIFEMLSGFPPFFDDNPFGIYQKILAGKLYFPRHLDFHVKTGRMM","proteinLength":"Fragment","predictedMolecularWeight":"53 kDa","actualMolecularWeight":null,"aminoAcidEnd":277,"aminoAcidStart":40,"nature":"Recombinant","expressionSystem":"Baculovirus infected Sf9 cells","accessionNumber":"O43930","tags":[{"tag":"GST","terminus":"N-Terminus"}]}]
style
left-column

Properties and storage information

Shipped at conditions
Dry Ice
Appropriate short-term storage conditions
-80°C
Appropriate long-term storage conditions
-80°C
Aliquoting information
Upon delivery aliquot
Storage information
Avoid freeze / thaw cycle
False
style
left-column

Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

Protein kinase Y linked also known as PKY is a serine/threonine kinase with a mass of approximately 60 kDa. It operates by transferring phosphate groups from ATP molecules to specific substrate proteins which modulates their activity. PKY is abundantly expressed in brain tissues especially the hippocampus and cerebral cortex. It's renowned for its role in regulating the cellular processes through phosphorylation.
Biological function summary

PKY orchestrates signal transduction pathways that control neuronal differentiation and synaptic plasticity. This kinase does not function alone; it often engages in large protein complexes that enable precise modulation of neural functions. Researchers frequently study PKY for its role in promoting neurogenesis and maintaining synaptic transmission highlighting its importance in brain health.

Pathways

PKY plays an important role in both the MAPK and PI3K-Akt signaling pathways. In the MAPK pathway PKY collaborates with proteins such as ERK to propagate signals that lead to cell growth and differentiation. In the PI3K-Akt pathway PKY interacts with proteins like mTOR contributing to the regulation of cell survival and metabolism underpinning its involvement in numerous cellular processes.

PKY exhibits strong connections with neurodegenerative diseases like Alzheimer's disease and Parkinson's disease. In Alzheimer's disease altered PKY activity associates with tau protein phosphorylation affecting neuronal stability. Similarly in Parkinson's disease PKY influences alpha-synuclein aggregation impacting dopaminergic neurons. These links make PKY a prominent target for therapeutic interventions aiming to alleviate or modify disease progression.
style
left-column

Specifications

Form

Liquid

Additional notes

Affinity purified.

style
left-column

General info

Sequence similarities

Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. cAMP subfamily.

style
left-column

Product protocols

style
left-column

Target data

See full target information PRKY
style
left-column
style
left-column
style
right-column

Complementary Products

Secondary Antibodies

AB150077

Goat Anti-Rabbit IgG H&L (Alexa Fluor® 488)

Immunocytochemistry/ Immunofluorescence - Goat Anti-Rabbit IgG H&L (Alexa Fluor® 488) (AB150077)

  • 5
  • 20
Secondary Antibodies

AB191866

VHH Single Domain Anti-Rabbit IgG Fc (HRP)

Recombinant

Western blot - VHH Single Domain Anti-Rabbit IgG Fc (HRP) (AB191866)

  • 5
  • 2
Proteins & Peptides

AB95857

Recombinant Human PIG3 protein

SDS-PAGE - Recombinant Human PIG3 protein (AB95857)

  • 0
  • 0
Proteins & Peptides

AB140418

Recombinant human TESK2 protein

Functional Studies - Recombinant human TESK2 protein (AB140418)

  • 0
  • 0

Product promise

We are committed to supporting your work with high-quality reagents, and we're here for you every step of the way. In the unlikely event that one of our products does not perform as expected, you're protected by our Product Promise.
For full details, please see our Terms & Conditions

Please note: All products are 'FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC OR THERAPEUTIC PROCEDURES'.

For licensing inquiries, please contact partnerships@abcam.com